[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/cd133-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/cd133-wikipedia\/","headline":"CD133 – Wikipedia","name":"CD133 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens CD133 antigen, also known as prominin-1, is a","datePublished":"2017-12-09","dateModified":"2017-12-09","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/www.wikimedia.org\/static\/images\/wmf-logo.png","url":"https:\/\/www.wikimedia.org\/static\/images\/wmf-logo.png","height":"101","width":"135"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/cd133-wikipedia\/","wordCount":11099,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensCD133 antigen, also known as prominin-1, is a glycoprotein that in humans is encoded by the PROM1 gene.[5][6] It is a member of pentaspan transmembrane glycoproteins, which specifically localize to cellular protrusions. When embedded in the cell membrane, the membrane topology of prominin-1 is such that the N-terminus extends into the extracellular space and the C-terminus resides in the intracellular compartment. The protein consists of five transmembrane segments, with the first and second segments and the third and fourth segments connected by intracellular loops while the second and third as well as fourth and fifth transmembrane segments are connected by extracellular loops.[7] While the precise function of CD133 remains unknown, it has been proposed that it acts as an organizer of cell membrane topology.[8]Table of ContentsTissue distribution[edit]Clinical significance[edit]See also[edit]References[edit]Further reading[edit]External links[edit]Tissue distribution[edit]CD133 is expressed in hematopoietic stem cells,[9]endothelial progenitor cells,[10]glioblastoma, neuronal and glial stem cells,[11] various pediatric brain tumors,[12] as well as adult kidney, mammary glands, trachea, salivary glands, uterus, placenta, digestive tract, testes, and some other cell types.[13][14][15]Clinical significance[edit]Today CD133 is the most commonly used marker for isolation of cancer stem cell (CSC) population from different tumors, mainly from various gliomas and carcinomas.[16] Initial studies that showed ability of CD133-positive population to efficiently propagate tumor when injected into immune-compromised mice firstly were performed on brain tumors.[17][12][18][19]  However, subsequent studies have indicated the difficulty in isolating pure CSC populations.[20] CD133+melanoma cells are considered a subpopulation of CSC and play a critical role in recurrence.[21] Moreover, CD133+ melanoma cells are immunogenic and can be used as an antimelanoma vaccination. In mice the vaccination with CD133+ melanoma cells mediated strong anti-tumor activity that resulted in the eradication of parental melanoma cells.[22] In addition, it has also been shown that CD133+ melanoma cells preferentially express the RNA helicase DDX3X . As DDX3X also is an immunogenic protein, the same anti-melanoma vaccination strategy can be employed to give therapeutic antitumor immunity in mice.[23]See also[edit]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000007062 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029086 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Yin AH, Miraglia S, Zanjani ED, Almeida-Porada G, Ogawa M, Leary AG, Olweus J, Kearney J, Buck DW (December 1997). “AC133, a novel marker for human hematopoietic stem and progenitor cells”. Blood. 90 (12): 5002\u201312. doi:10.1182\/blood.V90.12.5002. PMID\u00a09389720.^ Corbeil D, Fargeas CA, Huttner WB (July 2001). “Rat prominin, like its mouse and human orthologues, is a pentaspan membrane glycoprotein”. Biochemical and Biophysical Research Communications. 285 (4): 939\u201344. doi:10.1006\/bbrc.2001.5271. PMID\u00a011467842.^ Corbeil D, Karbanov\u00e1 J, Fargeas CA, J\u00e1szai J (2012-11-05). “Prominin-1 (CD133): Molecular and Cellular Features Across Species”. Advances in Experimental Medicine and Biology. 777: 3\u201324. doi:10.1007\/978-1-4614-5894-4_1. ISBN\u00a09781461458937. PMID\u00a023161072.^ Irollo E, Pirozzi G (September 2013). “CD133: to be or not to be, is this the real question?”. American Journal of Translational Research. 5 (6): 563\u201381. PMC\u00a03786264. PMID\u00a024093054.^ Horn PA, Tesch H, Staib P, Kube D, Diehl V, Voliotis D (February 1999). “Expression of AC133, a novel hematopoietic precursor antigen, on acute myeloid leukemia cells”. Blood. 93 (4): 1435\u20137. doi:10.1182\/blood.V93.4.1435. PMID\u00a010075457.^ Corbeil D, R\u00f6per K, Hellwig A, Tavian M, Miraglia S, Watt SM, Simmons PJ, Peault B, Buck DW, Huttner WB (February 2000). “The human AC133 hematopoietic stem cell antigen is also expressed in epithelial cells and targeted to plasma membrane protrusions”. The Journal of Biological Chemistry. 275 (8): 5512\u201320. doi:10.1074\/jbc.275.8.5512. PMID\u00a010681530.^ Sanai N, Alvarez-Buylla A, Berger MS (August 2005). “Neural stem cells and the origin of gliomas”. The New England Journal of Medicine. 353 (8): 811\u201322. doi:10.1056\/NEJMra043666. PMID\u00a016120861.^ a b Singh SK, Clarke ID, Terasaki M, Bonn VE, Hawkins C, Squire J, Dirks PB (September 2003). “Identification of a cancer stem cell in human brain tumors”. Cancer Research. 63 (18): 5821\u20138. PMID\u00a014522905.^ Mizrak D, Brittan M, Alison M (January 2008). “CD133: molecule of the moment”. The Journal of Pathology. 214 (1): 3\u20139. doi:10.1002\/path.2283. PMID\u00a018067118. S2CID\u00a044681326.^ Shmelkov SV, St Clair R, Lyden D, Rafii S (April 2005). “AC133\/CD133\/Prominin-1”. The International Journal of Biochemistry & Cell Biology. 37 (4): 715\u20139. doi:10.1016\/j.biocel.2004.08.010. PMID\u00a015694831.^ Dowland SN, Madawala RJ, Poon CE, Lindsay LA, Murphy CR (June 2017). “Prominin-1 glycosylation changes throughout early pregnancy in uterine epithelial cells under the influence of maternal ovarian hormones”. Reproduction, Fertility, and Development. 29 (6): 1194\u20131208. doi:10.1071\/RD15432. PMID\u00a027166505.^ Kim YS, Kaidina AM, Chiang JH, Yarygin KN, Lupatov AY (2017). “Cancer stem cell molecular markers verified in vivo”. Biochem. Moscow Suppl. Ser. B. 11 (1): 43\u201354. doi:10.1134\/S1990750817010036. S2CID\u00a090912166.^ Lai IC, Shih PH, Yao CJ, Yeh CT, Wang-Peng J, Lui TN, Chuang SE, Hu TS, Lai TY, Lai GM (2015). “Elimination of cancer stem-like cells and potentiation of temozolomide sensitivity by Honokiol in glioblastoma multiforme cells”. PLOS ONE. 10 (3): e0114830. Bibcode:2015PLoSO..1014830L. doi:10.1371\/journal.pone.0114830. PMC\u00a04357432. PMID\u00a025763821.^ Hemmati HD, Nakano I, Lazareff JA, Masterman-Smith M, Geschwind DH, Bronner-Fraser M, Kornblum HI (December 2003). “Cancerous stem cells can arise from pediatric brain tumors”. Proceedings of the National Academy of Sciences of the United States of America. 100 (25): 15178\u201383. Bibcode:2003PNAS..10015178H. doi:10.1073\/pnas.2036535100. PMC\u00a0299944. PMID\u00a014645703.^ Galli R, Binda E, Orfanelli U, Cipelletti B, Gritti A, De Vitis S, Fiocco R, Foroni C, Dimeco F, Vescovi A (October 2004). “Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma” (PDF). Cancer Research. 64 (19): 7011\u201321. doi:10.1158\/0008-5472.CAN-04-1364. hdl:2434\/585643. PMID\u00a015466194. S2CID\u00a014693017.^ Wang J, Sakariassen P\u00d8, Tsinkalovsky O, Immervoll H, B\u00f8e SO, Svendsen A, Prestegarden L, R\u00f8sland G, Thorsen F, Stuhr L, Molven A, Bjerkvig R, Enger P\u00d8 (February 2008). “CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells”. International Journal of Cancer. 122 (4): 761\u20138. doi:10.1002\/ijc.23130. PMID\u00a017955491. S2CID\u00a025435240.^ Monzani E, Facchetti F, Galmozzi E, Corsini E, Benetti A, Cavazzin C, Gritti A, Piccinini A, Porro D, Santinami M, Invernici G, Parati E, Alessandri G, La Porta CA (March 2007). “Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential”. European Journal of Cancer. 43 (5): 935\u201346. doi:10.1016\/j.ejca.2007.01.017. hdl:2434\/28996. PMID\u00a017320377.^ Miyabayashi T, Kagamu H, Koshio J, Ichikawa K, Baba J, Watanabe S, Tanaka H, Tanaka J, Yoshizawa H, Nakata K, Narita I (November 2011). “Vaccination with CD133(+) melanoma induces specific Th17 and Th1 cell-mediated antitumor reactivity against parental tumor”. Cancer Immunology, Immunotherapy. 60 (11): 1597\u2013608. doi:10.1007\/s00262-011-1063-x. PMID\u00a021691723. S2CID\u00a025329727.^ Koshio J, Kagamu H, Nozaki K, Saida Y, Tanaka T, Shoji S, Igarashi N, Miura S, Okajima M, Watanabe S, Yoshizawa H, Narita I (October 2013). “DEAD\/H (Asp-Glu-Ala-Asp\/His) box polypeptide 3, X-linked is an immunogenic target of cancer stem cells”. Cancer Immunology, Immunotherapy. 62 (10): 1619\u201328. doi:10.1007\/s00262-013-1467-x. PMID\u00a023974721. S2CID\u00a025347678.Further reading[edit]Shimizu K, Itoh T, Shimizu M, Ku Y, Hori Y (November 2009). “CD133 expression pattern distinguishes intraductal papillary mucinous neoplasms from ductal adenocarcinomas of the pancreas” (PDF). Pancreas. 38 (8): e207-14. doi:10.1097\/MPA.0b013e3181bb5037. PMID\u00a019786935. S2CID\u00a025675719.Bertolini G, Roz L, Perego P, Tortoreto M, Fontanella E, Gatti L, Pratesi G, Fabbri A, Andriani F, Tinelli S, Roz E, Caserini R, Lo Vullo S, Camerini T, Mariani L, Delia D, Calabr\u00f2 E, Pastorino U, Sozzi G (September 2009). “Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment”. Proceedings of the National Academy of Sciences of the United States of America. 106 (38): 16281\u20136. Bibcode:2009PNAS..10616281B. doi:10.1073\/pnas.0905653106. PMC\u00a02741477. PMID\u00a019805294.Salnikov AV, Gladkich J, Moldenhauer G, Volm M, Mattern J, Herr I (February 2010). “CD133 is indicative for a resistance phenotype but does not represent a prognostic marker for survival of non-small cell lung cancer patients”. International Journal of Cancer. 126 (4): 950\u20138. doi:10.1002\/ijc.24822. PMID\u00a019676044. S2CID\u00a023335006.Nishide K, Nakatani Y, Kiyonari H, Kondo T (August 2009).  Lowenstein PR (ed.). “Glioblastoma formation from cell population depleted of Prominin1-expressing cells”. PLOS ONE. 4 (8): e6869. Bibcode:2009PLoSO…4.6869N. doi:10.1371\/journal.pone.0006869. PMC\u00a02729925. PMID\u00a019718438.Na YR, Seok SH, Kim DJ, Han JH, Kim TH, Jung H, Lee BH, Park JH (2009). “Isolation and characterization of spheroid cells from human malignant melanoma cell line WM-266-4”. Tumour Biology. 30 (5\u20136): 300\u20139. doi:10.1159\/000261073. PMID\u00a019940551. S2CID\u00a040841423.Sun Y, Kong W, Falk A, Hu J, Zhou L, Pollard S, Smith A (2009).  Ch\u00e9dotal A (ed.). “CD133 (Prominin) negative human neural stem cells are clonogenic and tripotent”. PLOS ONE. 4 (5): e5498. Bibcode:2009PLoSO…4.5498S. doi:10.1371\/journal.pone.0005498. PMC\u00a02676510. PMID\u00a019430532.Wu X, Spitz MR, Lee JJ, Lippman SM, Ye Y, Yang H, Khuri FR, Kim E, Gu J, Lotan R, Hong WK (July 2009). “Novel susceptibility loci for second primary tumors\/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants”. Cancer Prevention Research. 2 (7): 617\u201324. doi:10.1158\/1940-6207.CAPR-09-0025. PMC\u00a02964280. PMID\u00a019584075.Yao J, Zhang T, Ren J, Yu M, Wu G (October 2009). “Effect of CD133\/prominin-1 antisense oligodeoxynucleotide on in vitro growth characteristics of Huh-7 human hepatocarcinoma cells and U251 human glioma cells”. Oncology Reports. 22 (4): 781\u20137. doi:10.3892\/or_00000500. PMID\u00a019724856.Yasuda H, Tanaka K, Saigusa S, Toiyama Y, Koike Y, Okugawa Y, Yokoe T, Kawamoto A, Inoue Y, Miki C, Kusunoki M (October 2009). “Elevated CD133, but not VEGF or EGFR, as a predictive marker of distant recurrence after preoperative chemoradiotherapy in rectal cancer”. Oncology Reports. 22 (4): 709\u201317. doi:10.3892\/or_00000491. PMID\u00a019724847.Yoshikawa S, Zen Y, Fujii T, Sato Y, Ohta T, Aoyagi Y, Nakanuma Y (October 2009). “Characterization of CD133+ parenchymal cells in the liver: histology and culture”. World Journal of Gastroenterology. 15 (39): 4896\u2013906. doi:10.3748\/wjg.15.4896. PMC\u00a02764966. PMID\u00a019842219.Ferrandina G, Martinelli E, Petrillo M, Prisco MG, Zannoni G, Sioletic S, Scambia G (July 2009). “CD133 antigen expression in ovarian cancer”. BMC Cancer. 9: 221. doi:10.1186\/1471-2407-9-221. PMC\u00a03224735. PMID\u00a019583859.Wang Q, Chen ZG, Du CZ, Wang HW, Yan L, Gu J (September 2009). “Cancer stem cell marker CD133+ tumour cells and clinical outcome in rectal cancer”. Histopathology. 55 (3): 284\u201393. doi:10.1111\/j.1365-2559.2009.03378.x. PMID\u00a019723143. S2CID\u00a012088193.Friedman S, Lu M, Schultz A, Thomas D, Lin RY (2009).  Breant B (ed.). “CD133+ anaplastic thyroid cancer cells initiate tumors in immunodeficient mice and are regulated by thyrotropin”. PLOS ONE. 4 (4): e5395. Bibcode:2009PLoSO…4.5395F. doi:10.1371\/journal.pone.0005395. PMC\u00a02671400. PMID\u00a019404394.Cheng JX, Liu BL, Zhang X (August 2009). “How powerful is CD133 as a cancer stem cell marker in brain tumors?”. Cancer Treatment Reviews. 35 (5): 403\u20138. doi:10.1016\/j.ctrv.2009.03.002. PMID\u00a019369008.Horst D, Kriegl L, Engel J, Kirchner T, Jung A (October 2009). “Prognostic significance of the cancer stem cell markers CD133, CD44, and CD166 in colorectal cancer”. Cancer Investigation. 27 (8): 844\u201350. doi:10.1080\/07357900902744502. PMID\u00a019626493. S2CID\u00a035888000.Yeh CT, Kuo CJ, Lai MW, Chen TC, Lin CY, Yeh TS, Lee WC (September 2009). “CD133-positive hepatocellular carcinoma in an area endemic for hepatitis B virus infection”. BMC Cancer. 9: 324. doi:10.1186\/1471-2407-9-324. PMC\u00a02753636. PMID\u00a019744348.Li CY, Li BX, Liang Y, Peng RQ, Ding Y, Xu DZ, Zhang X, Pan ZZ, Wan DS, Zeng YX, Zhu XF, Zhang XS (July 2009). “Higher percentage of CD133+ cells is associated with poor prognosis in colon carcinoma patients with stage IIIB”. Journal of Translational Medicine. 7: 56. doi:10.1186\/1479-5876-7-56. PMC\u00a02715381. PMID\u00a019583834.Hibi K, Sakata M, Sakuraba K, Shirahata A, Goto T, Mizukami H, Saito M, Ishibashi K, Kigawa G, Nemoto H, Sanada Y (2009). “CD133 gene overexpression is frequently observed in early colorectal carcinoma”. Hepato-Gastroenterology. 56 (93): 995\u20137. PMID\u00a019760928.Pras E, Abu A, Rotenstreich Y, Avni I, Reish O, Morad Y, Reznik-Wolf H, Pras E (August 2009). “Cone-rod dystrophy and a frameshift mutation in the PROM1 gene”. Molecular Vision. 15: 1709\u201316. PMC\u00a02732717. PMID\u00a019718270.Rutella S, Bonanno G, Procoli A, Mariotti A, Corallo M, Prisco MG, Eramo A, Napoletano C, Gallo D, Perillo A, Nuti M, Pierelli L, Testa U, Scambia G, Ferrandina G (July 2009). “Cells with characteristics of cancer stem\/progenitor cells express the CD133 antigen in human endometrial tumors”. Clinical Cancer Research. 15 (13): 4299\u2013311. doi:10.1158\/1078-0432.CCR-08-1883. PMID\u00a019509143.External links[edit]Wikimedia ErrorOur servers are currently under maintenance or experiencing a technical problem.Please try again in a few\u00a0minutes.See the error message at the bottom of this page for more\u00a0information. 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