[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/cdc5l-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/cdc5l-wikipedia\/","headline":"CDC5L – Wikipedia","name":"CDC5L – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Cell division cycle 5-like protein is","datePublished":"2014-06-11","dateModified":"2014-06-11","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/3\/36\/PDB_2dim_EBI.png\/180px-PDB_2dim_EBI.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/3\/36\/PDB_2dim_EBI.png\/180px-PDB_2dim_EBI.png","height":"135","width":"180"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/cdc5l-wikipedia\/","about":["Wiki"],"wordCount":7643,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensCell division cycle 5-like protein is a protein that in humans is encoded by the CDC5L gene.[5][6][7]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Table of ContentsFunction[edit]Interactions[edit]See also[edit]References[edit]Further reading[edit]External links[edit]Function[edit]The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2\/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2\/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing.[7]Interactions[edit]CDC5L has been shown to interact with:       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4ASF\/SF2,[8]BZW1,[8]CWC15,[8]DNA-PKcs,[8]DYNC1H1,[8]GCN1L1,[8]HSPA8,[8]ILF2,[8]PLRG1,[8][9][10][11]PPM1D,[8]PPP1CA,[8]PRPF19,[8]RBMX[8] andRPL12,[8]RPL13,[8]RPS16,[8]RPS25,[8]SF3A1,[8]SF3B1,[8]SF3B2,[8]SF3B4,[8]SFPQ,[8]SFRS2,[8]SNRPA1,[8]SNRPD3,[8]SRRM1,[8]Small nuclear ribonucleoprotein D1,[8]Small nuclear ribonucleoprotein D2,[8]Small nuclear ribonucleoprotein polypeptide A,[8]TOP2A,[8]  andTTF2.[12]See also[edit]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000096401 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023932 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Groenen PM, Vanderlinden G, Devriendt K, Fryns JP, Van de Ven WJ (Apr 1998). “Rearrangement of the human CDC5L gene by a t(6;19)(p21;q13.1) in a patient with multicystic renal dysplasia”. Genomics. 49 (2): 218\u201329. doi:10.1006\/geno.1998.5254. PMID\u00a09598309.^ Bernstein HS, Coughlin SR (Feb 1997). “Pombe Cdc5-related protein. A putative human transcription factor implicated in mitogen-activated signaling”. The Journal of Biological Chemistry. 272 (9): 5833\u20137. doi:10.1074\/jbc.272.9.5833. PMID\u00a09038199.^ a b “Entrez Gene: CDC5L CDC5 cell division cycle 5-like (S. pombe)”.^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (Dec 2000). “Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry”. The EMBO Journal. 19 (23): 6569\u201381. doi:10.1093\/emboj\/19.23.6569. PMC\u00a0305846. PMID\u00a011101529.^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O’Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). “Large-scale mapping of human protein-protein interactions by mass spectrometry”. Molecular Systems Biology. 3: 89. doi:10.1038\/msb4100134. PMC\u00a01847948. PMID\u00a017353931.^ Ajuh P, Lamond AI (Nov 2003). “Identification of peptide inhibitors of pre-mRNA splicing derived from the essential interaction domains of CDC5L and PLRG1”. Nucleic Acids Research. 31 (21): 6104\u201316. doi:10.1093\/nar\/gkg817. PMC\u00a0275459. PMID\u00a014576297.^ Ajuh P, Sleeman J, Chusainow J, Lamond AI (Nov 2001). “A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing”. The Journal of Biological Chemistry. 276 (45): 42370\u201381. doi:10.1074\/jbc.M105453200. PMID\u00a011544257.^ Leonard D, Ajuh P, Lamond AI, Legerski RJ (Sep 2003). “hLodestar\/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing”. Biochemical and Biophysical Research Communications. 308 (4): 793\u2013801. CiteSeerX\u00a010.1.1.539.8359. doi:10.1016\/s0006-291x(03)01486-4. PMID\u00a012927788.Further reading[edit]Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). “Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones”. DNA Research. 9 (3): 99\u2013106. CiteSeerX\u00a010.1.1.500.923. doi:10.1093\/dnares\/9.3.99. PMID\u00a012168954.Heaney JP, Jacobson A (Aug 1975). “Simplified control of upper abdominal hemorrhage from the vena cava”. Surgery. 78 (2): 138\u201341. PMID\u00a01154257.Hirayama T, Shinozaki K (Nov 1996). “A cdc5+ homolog of a higher plant, Arabidopsis thaliana”. Proceedings of the National Academy of Sciences of the United States of America. 93 (23): 13371\u20136. doi:10.1073\/pnas.93.23.13371. PMC\u00a024100. PMID\u00a08917598.Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1997). “Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro”. DNA Research. 4 (5): 307\u201313. doi:10.1093\/dnares\/4.5.307. PMID\u00a09455477.Bernstein HS, Coughlin SR (Feb 1998). “A mammalian homolog of fission yeast Cdc5 regulates G2 progression and mitotic entry”. The Journal of Biological Chemistry. 273 (8): 4666\u201371. doi:10.1074\/jbc.273.8.4666. PMID\u00a09468527.Ohi R, Feoktistova A, McCann S, Valentine V, Look AT, Lipsick JS, Gould KL (Jul 1998). “Myb-related Schizosaccharomyces pombe cdc5p is structurally and functionally conserved in eukaryotes”. Molecular and Cellular Biology. 18 (7): 4097\u2013108. doi:10.1128\/mcb.18.7.4097. PMC\u00a0108994. PMID\u00a09632794.Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M (Sep 1998). “Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex”. Nature Genetics. 20 (1): 46\u201350. doi:10.1038\/1700. PMID\u00a09731529. S2CID\u00a0585778.Burns CG, Ohi R, Krainer AR, Gould KL (Nov 1999). “Evidence that Myb-related CDC5 proteins are required for pre-mRNA splicing”. Proceedings of the National Academy of Sciences of the United States of America. 96 (24): 13789\u201394. doi:10.1073\/pnas.96.24.13789. PMC\u00a024143. PMID\u00a010570151.Boudrez A, Beullens M, Groenen P, Van Eynde A, Vulsteke V, Jagiello I, Murray M, Krainer AR, Stalmans W, Bollen M (Aug 2000). “NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry”. The Journal of Biological Chemistry. 275 (33): 25411\u20137. doi:10.1074\/jbc.M001676200. PMID\u00a010827081.Lei XH, Shen X, Xu XQ, Bernstein HS (Dec 2000). “Human Cdc5, a regulator of mitotic entry, can act as a site-specific DNA binding protein”. Journal of Cell Science. 113. 113 (24): 4523\u201331. doi:10.1242\/jcs.113.24.4523. PMID\u00a011082045.Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (Dec 2000). “Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry”. The EMBO Journal. 19 (23): 6569\u201381. doi:10.1093\/emboj\/19.23.6569. PMC\u00a0305846. PMID\u00a011101529.Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L, Costanzo D, McElligott K, Boozer S, Mays R, Smith E, Veloso N, Klika A, Hess J, Cothren K, Lo K, Offenbacher J, Danzig J, Ducar M (May 2001). “Creation of genome-wide protein expression libraries using random activation of gene expression”. Nature Biotechnology. 19 (5): 440\u20135. doi:10.1038\/88107. PMID\u00a011329013. S2CID\u00a025064683.Ajuh P, Sleeman J, Chusainow J, Lamond AI (Nov 2001). “A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing”. The Journal of Biological Chemistry. 276 (45): 42370\u201381. doi:10.1074\/jbc.M105453200. PMID\u00a011544257.Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (Apr 2002). “Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis”. RNA. 8 (4): 426\u201339. doi:10.1017\/S1355838202021088. PMC\u00a01370266. PMID\u00a011991638.Leonard D, Ajuh P, Lamond AI, Legerski RJ (Sep 2003). “hLodestar\/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing”. Biochemical and Biophysical Research Communications. 308 (4): 793\u2013801. CiteSeerX\u00a010.1.1.539.8359. doi:10.1016\/S0006-291X(03)01486-4. PMID\u00a012927788.Liu L, Gr\u00e4ub R, Hlaing M, Epting CL, Turck CW, Xu XQ, Zhang L, Bernstein HS (2004). “Distinct domains of human CDC5 direct its nuclear import and association with the spliceosome”. Cell Biochemistry and Biophysics. 39 (2): 119\u201332. doi:10.1385\/CBB:39:2:119. PMID\u00a014515018. S2CID\u00a022472390.External links[edit]PDB gallery2dim: Solution structure of the Myb_DNA-binding domain of human Cell division cycle 5-like protein2din: Solution structure of the Myb_DNA-binding domain of human Cell division cycle 5-like protein       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/cdc5l-wikipedia\/#breadcrumbitem","name":"CDC5L – Wikipedia"}}]}]