[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/cholecystokinin-a-receptor-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/cholecystokinin-a-receptor-wikipedia\/","headline":"Cholecystokinin A receptor – Wikipedia","name":"Cholecystokinin A receptor – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens The Cholecystokinin A receptor is a human protein,","datePublished":"2018-09-09","dateModified":"2018-09-09","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/4\/49\/PDB_1d6g_EBI.jpg\/180px-PDB_1d6g_EBI.jpg","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/4\/49\/PDB_1d6g_EBI.jpg\/180px-PDB_1d6g_EBI.jpg","height":"135","width":"180"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/cholecystokinin-a-receptor-wikipedia\/","wordCount":5315,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensThe Cholecystokinin A receptor is a human protein, also known as CCKAR or CCK1, with CCK1 now being the IUPHAR-recommended name.Table of ContentsFunction[edit]Selective Ligands[edit]Agonists[edit]Antagonists[edit]See also[edit]References[edit]External links[edit]Further reading[edit]Function[edit]This gene encodes a G-protein coupled receptor that binds sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine.[5]The extracellular, N-terminal, domain of this protein adopts a tertiary structure consisting of a few helical turns and a disulfide-cross linked loop. It is required for interaction of the cholecystokinin A receptor with its corresponding hormonal ligand.[6]Selective Ligands[edit]Agonists[edit]CholecystokininCCK-4SR-146,131A-71623 – modified tetrapeptide, potent and selective CCKA agonist, IC50 3.7nM, 1200x selectivity over CCKB, CAS# 130408-77-4Antagonists[edit]See also[edit]References[edit]External links[edit]Further reading[edit]Varga G, B\u00e1lint A, Burghardt B, D’Amato M (Apr 2004). “Involvement of endogenous CCK and CCK1 receptors in colonic motor function”. British Journal of Pharmacology. 141 (8): 1275\u201384. doi:10.1038\/sj.bjp.0705769. PMC\u00a01574909. PMID\u00a015100163.Wang J, Si YM, Liu ZL, Yu L (Jun 2003). “Cholecystokinin, cholecystokinin-A receptor and cholecystokinin-B receptor gene polymorphisms in Parkinson’s disease”. Pharmacogenetics. 13 (6): 365\u20139. doi:10.1097\/00008571-200306000-00008. PMID\u00a012777967.Miller LJ, Holicky EL, Ulrich CD, Wieben ED (Oct 1995). “Abnormal processing of the human cholecystokinin receptor gene in association with gallstones and obesity”. Gastroenterology. 109 (4): 1375\u201380. doi:10.1016\/0016-5085(95)90601-0. PMID\u00a07557108.Huppi K, Siwarski D, Pisegna JR, Wank S (Feb 1995). “Chromosomal localization of the gastric and brain receptors for cholecystokinin (CCKAR and CCKBR) in human and mouse”. Genomics. 25 (3): 727\u20139. doi:10.1016\/0888-7543(95)80018-H. PMC\u00a06736545. PMID\u00a07759110.de Weerth A, Pisegna JR, Huppi K, Wank SA (Jul 1993). “Molecular cloning, functional expression and chromosomal localization of the human cholecystokinin type A receptor”. Biochemical and Biophysical Research Communications. 194 (2): 811\u20138. doi:10.1006\/bbrc.1993.1894. PMID\u00a08343165.Ulrich CD, Ferber I, Holicky E, Hadac E, Buell G, Miller LJ (May 1993). “Molecular cloning and functional expression of the human gallbladder cholecystokinin A receptor”. Biochemical and Biophysical Research Communications. 193 (1): 204\u201311. doi:10.1006\/bbrc.1993.1610. PMID\u00a08503909.Kennedy K, Gigoux V, Escrieut C, Maigret B, Martinez J, Moroder L, Fr\u00e9hel D, Gully D, Vaysse N, Fourmy D (Jan 1997). “Identification of two amino acids of the human cholecystokinin-A receptor that interact with the N-terminal moiety of cholecystokinin”. The Journal of Biological Chemistry. 272 (5): 2920\u20136. doi:10.1074\/jbc.272.5.2920. PMID\u00a09006937.Inoue H, Iannotti CA, Welling CM, Veile R, Donis-Keller H, Permutt MA (Jun 1997). “Human cholecystokinin type A receptor gene: cytogenetic localization, physical mapping, and identification of two missense variants in patients with obesity and non-insulin-dependent diabetes mellitus (NIDDM)”. Genomics. 42 (2): 331\u20135. doi:10.1006\/geno.1997.4749. PMID\u00a09192855.Gigoux V, Escrieut C, Silvente-Poirot S, Maigret B, Gouilleux L, Fehrentz JA, Gully D, Moroder L, Vaysse N, Fourmy D (Jun 1998). “Met-195 of the cholecystokinin-A receptor interacts with the sulfated tyrosine of cholecystokinin and is crucial for receptor transition to high affinity state”. The Journal of Biological Chemistry. 273 (23): 14380\u20136. doi:10.1074\/jbc.273.23.14380. PMID\u00a09603948.Funakoshi A, Fukamizu Y, Miyasaka K (2000). “Mechanism of cholecystokinin-A- receptor antagonist on human pancreatic exocrine secretion. Localization of CCK-A receptor in the human duodenum”. Digestion. 60 Suppl 1: 75\u201380. doi:10.1159\/000051459. PMID\u00a010026437. S2CID\u00a041117645.Gigoux V, Escrieut C, Fehrentz JA, Poirot S, Maigret B, Moroder L, Gully D, Martinez J, Vaysse N, Fourmy D (Jul 1999). “Arginine 336 and asparagine 333 of the human cholecystokinin-A receptor binding site interact with the penultimate aspartic acid and the C-terminal amide of cholecystokinin”. The Journal of Biological Chemistry. 274 (29): 20457\u201364. doi:10.1074\/jbc.274.29.20457. PMID\u00a010400673.Gigoux V, Maigret B, Escrieut C, Silvente-Poirot S, Bouisson M, Fehrentz JA, Moroder L, Gully D, Martinez J, Vaysse N, Fourmy AD (Nov 1999). “Arginine 197 of the cholecystokinin-A receptor binding site interacts with the sulfate of the peptide agonist cholecystokinin”. Protein Science. 8 (11): 2347\u201354. doi:10.1110\/ps.8.11.2347. PMC\u00a02144185. PMID\u00a010595537.Funakoshi A, Miyasaka K, Matsumoto H, Yamamori S, Takiguchi S, Kataoka K, Takata Y, Matsusue K, Kono A, Shimokata H (Jan 2000). “Gene structure of human cholecystokinin (CCK) type-A receptor: body fat content is related to CCK type-A receptor gene promoter polymorphism”. FEBS Letters. 466 (2\u20133): 264\u20136. doi:10.1016\/S0014-5793(00)01080-2. PMID\u00a010682840. S2CID\u00a011683500.Tachikawa H, Harada S, Kawanishi Y, Okubo T, Shiraishi H (Apr 2000). “Novel polymorphisms of the human cholecystokinin A receptor gene: an association analysis with schizophrenia”. American Journal of Medical Genetics. 96 (2): 141\u20135. doi:10.1002\/(SICI)1096-8628(20000403)96:23.0.CO;2-R. PMID\u00a010893485.Giragossian C, Mierke DF (Apr 2001). “Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin A receptor”. Biochemistry. 40 (13): 3804\u20139. doi:10.1021\/bi002659n. PMID\u00a011300760.Schmitz F, Schrader H, Otte J, Schmitz H, St\u00fcber E, Herzig K, Schmidt WE (Sep 2001). “Identification of CCK-B\/gastrin receptor splice variants in human peripheral blood mononuclear cells”. Regulatory Peptides. 101 (1\u20133): 25\u201333. doi:10.1016\/S0167-0115(01)00281-6. PMID\u00a011495676. S2CID\u00a022693627.Tachikawa H, Harada S, Kawanishi Y, Okubo T, Suzuki T (Sep 2001). “Linked polymorphisms (-333G>T and -286A>G) in the promoter region of the CCK-A receptor gene may be associated with schizophrenia”. Psychiatry Research. 103 (2\u20133): 147\u201355. doi:10.1016\/S0165-1781(01)00276-1. PMID\u00a011549403. S2CID\u00a024442175.Schmitz F, G\u00f6ke MN, Otte JM, Schrader H, Reimann B, Kruse ML, Siegel EG, Peters J, Herzig KH, F\u00f6lsch UR, Schmidt WE (Dec 2001). “Cellular expression of CCK-A and CCK-B\/gastrin receptors in human gastric mucosa”. Regulatory Peptides. 102 (2\u20133): 101\u201310. doi:10.1016\/S0167-0115(01)00307-X. PMID\u00a011730982. S2CID\u00a042131386.Okubo T, Harada S, Higuchi S, Matsushita S (Aug 2002). “Investigation of quantitative trait loci in the CCKAR gene with susceptibility to alcoholism”. Alcoholism: Clinical and Experimental Research. 26 (8 Suppl): 2S\u20135S. doi:10.1111\/j.1530-0277.2002.tb02693.x. PMID\u00a012198366.Takata Y, Takeda S, Kawanami T, Takiguchi S, Yoshida Y, Miyasaka K, Funakoshi A (2003). “Promoter analysis of human cholecystokinin type-A receptor gene”. Journal of Gastroenterology. 37 (10): 815\u201320. doi:10.1007\/s005350200135. PMID\u00a012424565. S2CID\u00a035526543.This article incorporates text from the United States National Library of Medicine, which is in the public domain.PDB gallery1d6g: MOLECULAR COMPLEX OF CHOLECYSTOKININ-8 AND N-TERMINUS OF THE CHOLECYSTOKININ A RECEPTOR BY NMR SPECTROSCOPY  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/cholecystokinin-a-receptor-wikipedia\/#breadcrumbitem","name":"Cholecystokinin A receptor – Wikipedia"}}]}]