[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/chondroitin-b-lyase-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/chondroitin-b-lyase-wikipedia\/","headline":"Chondroitin B lyase – Wikipedia","name":"Chondroitin B lyase – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 The enzyme chondroitin B lyase (EC 4.2.2.19) catalyzes the following process: Eliminative cleavage","datePublished":"2019-08-18","dateModified":"2019-08-18","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/www.wikimedia.org\/static\/images\/wmf-logo.png","url":"https:\/\/www.wikimedia.org\/static\/images\/wmf-logo.png","height":"101","width":"135"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/chondroitin-b-lyase-wikipedia\/","wordCount":3498,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4The enzyme chondroitin B lyase (EC 4.2.2.19) catalyzes the following process:Eliminative cleavage of dermatan sulfate containing (1\u21924)-\u03b2-D-hexosaminyl and (1\u21923)-\u03b2-D-glucurosonyl or (1\u21923)-\u03b1-L-iduronosyl linkages to disaccharides containing 4-deoxy-\u03b2-D-gluc-4-enuronosyl groups to yield a 4,5-unsaturated dermatan-sulfate disaccharide (\u0394UA-GalNAc-4S).Glossary:       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on polysaccharides.  The systematic name of this enzyme class is chondroitin B lyase. Other names in common use include chondroitinase B, ChonB, and ChnB.References[edit]Gu K, Linhardt RJ, Laliberte M, Gu K, Zimmermann J (1995). “Purification, characterization and specificity of chondroitin lyases and glycuronidase from Flavobacterium heparinum”. Biochem. J. 312 (Pt 2): 569\u201377. doi:10.1042\/bj3120569. PMC\u00a01136300. PMID\u00a08526872.Pojasek K, Raman R, Kiley P, Venkataraman G, Sasisekharan R (2002). “Biochemical characterization of the chondroitinase B active site”. J. Biol. Chem. 277 (34): 31179\u201386. doi:10.1074\/jbc.M201552200. PMID\u00a012063249.Pojasek K, Shriver Z, Kiley P, Venkataraman G, Sasisekharan R (2001). “Recombinant expression, purification, and kinetic characterization of chondroitinase AC and chondroitinase B from Flavobacterium heparinum”. Biochem. Biophys. Res. Commun. 286 (2): 343\u201351. doi:10.1006\/bbrc.2001.5380. PMID\u00a011500043.Suzuki K, Terasaki Y, Uyeda M (2002). “Inhibition of hyaluronidases and chondroitinases by fatty acids”. J. Enzyme. Inhib. Med. Chem. 17 (3): 183\u20136. doi:10.1080\/14756360290032930. PMID\u00a012443044.Ototani N, Yosizawa Z (1979). “Purification of chondroitinase B and chondroitinase C using glycosaminoglycan-bound AH-Sepharose 4B”. Carbohydr. Res. 70 (2): 295\u2013306. doi:10.1016\/S0008-6215(00)87109-8. PMID\u00a0427837.K, Zimmermann JJ; Su H (2000). “Isolation and Expression in Escherichia coli of cslA and cslB, Genes Coding for the Chondroitin Sulfate-Degrading Enzymes Chondroitinase AC and Chondroitinase B, Respectively, from Flavobacterium heparinum”. Appl. Environ. Microbiol. 66 (1): 29\u201335. doi:10.1128\/AEM.66.1.29-35.2000. PMC\u00a091781. PMID\u00a010618199.V, Sasisekharan R, Cygler M (2004). “The structure of chondroitin B lyase complexed with glycosaminoglycan oligosaccharides unravels a calcium-dependent catalytic machinery”. J. Biol. Chem. 279 (31): 32882\u201396. doi:10.1074\/jbc.M403421200. PMC\u00a04135467. PMID\u00a015155751.Li Y, Matte A, Su H, Cygler M (1999). “Crystallization and preliminary X-ray analysis of chondroitinase B from Flavobacterium heparinum”. Acta Crystallogr. D. 55 (Pt 5): 1055\u20137. doi:10.1107\/S0907444999002097. PMID\u00a010216304.Huang W, Matte A, Li Y, Kim YS, Linhardt RJ, Su H, Cygler M (1999). “Crystal structure of chondroitinase B from Flavobacterium heparinum and its complex with a disaccharide product at 1.7 A resolution”. J. Mol. Biol. 294 (5): 1257\u201369. doi:10.1006\/jmbi.1999.3292. PMID\u00a010600383.Lauder RM; Nieduszynski, IA; Giannopoulos, M; Weeks, SD; Sadler, IH; Lauder, RM (2005). “Characterization of oligosaccharides from the chondroitin\/dermatan sulfates. 1H-NMR and 13C-NMR studies of reduced trisaccharides and hexasaccharides”. FEBS J. 272 (24): 6276\u201386. doi:10.1111\/j.1742-4658.2005.05009.x. 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