[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/chrfam7a-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/chrfam7a-wikipedia\/","headline":"CHRFAM7A – Wikipedia","name":"CHRFAM7A – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens CHRNA7-FAM7A fusion protein is a protein that in","datePublished":"2017-08-12","dateModified":"2017-08-12","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/chrfam7a-wikipedia\/","about":["Wiki"],"wordCount":3778,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensCHRNA7-FAM7A fusion protein is a protein that in humans is encoded by the CHRFAM7A gene.[3][4]The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed.[4]CHRFAM7A has not been found in nonhuman primates, and its occurrence in individuals of African descent is significantly lower than in Caucasian populations.[5]References[edit]^ a b c ENSG00000166664 GRCh38: Ensembl release 89: ENSG00000275917, ENSG00000166664 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Riley B, Williamson M, Collier D, Wilkie H, Makoff A (Feb 2002). “A 3-Mb map of a large Segmental duplication overlapping the alpha7-nicotinic acetylcholine receptor gene (CHRNA7) at human 15q13-q14”. Genomics. 79 (2): 197\u2013209. doi:10.1006\/geno.2002.6694. PMID\u00a011829490.^ a b “Entrez Gene: CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion”.^ Szafranski, Przemyslaw; Schaaf, Christian P.; Person, Richard E.; Gibson, Ian B.; Xia, Zhilian; Mahadevan, Sangeetha; Wiszniewska, Joanna; Bacino, Carlos A.; Lalani, Seema (2010-07-01). “Structures and Molecular Mechanisms for Common 15q13.3 Microduplications Involving CHRNA7: Benign or Pathological?”. Human Mutation. 31 (7): 840\u2013850. doi:10.1002\/humu.21284. ISSN\u00a01059-7794. PMC\u00a03162316. PMID\u00a020506139.External links[edit]Further reading[edit]Gault J, Robinson M, Berger R,  et\u00a0al. (1998). “Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7)”. Genomics. 52 (2): 173\u201385. doi:10.1006\/geno.1998.5363. PMID\u00a09782083.Freedman R, Leonard S, Gault JM,  et\u00a0al. (2001). “Linkage disequilibrium for schizophrenia at the chromosome 15q13-14 locus of the alpha7-nicotinic acetylcholine receptor subunit gene (CHRNA7)”. Am. J. Med. Genet. 105 (1): 20\u20132. doi:10.1002\/1096-8628(20010108)105:13.0.CO;2-C. PMID\u00a011424985. S2CID\u00a037412240.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Trombino S, Cesario A, Margaritora S,  et\u00a0al. (2004). “Alpha7-nicotinic acetylcholine receptors affect growth regulation of human mesothelioma cells: role of mitogen-activated protein kinase pathway”. Cancer Res. 64 (1): 135\u201345. doi:10.1158\/0008-5472.CAN-03-1672. PMID\u00a014729617.Gerhard DS, Wagner L, Feingold EA,  et\u00a0al. (2004). “The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121\u20137. doi:10.1101\/gr.2596504. PMC\u00a0528928. PMID\u00a015489334.Bale AS, Meacham CA, Benignus VA,  et\u00a0al. (2005). “Volatile organic compounds inhibit human and rat neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes”. Toxicol. Appl. Pharmacol. 205 (1): 77\u201388. doi:10.1016\/j.taap.2004.09.011. PMID\u00a015885267.Freedman R, Leonard S, Waldo M,  et\u00a0al. (2006). “Characterization of allelic variants at chromosome 15q14 in schizophrenia”. Genes, Brain and Behavior. 5 Suppl 1: 14\u201322. doi:10.1111\/j.1601-183X.2006.00190.x. PMID\u00a016417613.Zody MC, Garber M, Sharpe T,  et\u00a0al. (2006). “Analysis of the DNA sequence and duplication history of human chromosome 15”. Nature. 440 (7084): 671\u20135. Bibcode:2006Natur.440..671Z. doi:10.1038\/nature04601. PMID\u00a016572171.Dempster EL, Toulopoulou T, McDonald C,  et\u00a0al. (2006). “Episodic memory performance predicted by the 2bp deletion in exon 6 of the “alpha 7-like” nicotinic receptor subunit gene”. The American Journal of Psychiatry. 163 (10): 1832\u20134. doi:10.1176\/appi.ajp.163.10.1832. PMID\u00a017012698.Martin LF, Leonard S, Hall MH,  et\u00a0al. (2007). “Sensory Gating and Alpha-7 Nicotinic Receptor Gene Allelic Variants in Schizoaffective Disorder, Bipolar Type”. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (5): 611\u20134. doi:10.1002\/ajmg.b.30470. PMC\u00a03123155. PMID\u00a017192894.  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/chrfam7a-wikipedia\/#breadcrumbitem","name":"CHRFAM7A – Wikipedia"}}]}]