[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/chymotrypsin-c-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/chymotrypsin-c-wikipedia\/","headline":"Chymotrypsin-C – Wikipedia","name":"Chymotrypsin-C – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Chymotrypsin C, also known as caldecrin or elastase","datePublished":"2019-01-21","dateModified":"2019-01-21","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/chymotrypsin-c-wikipedia\/","wordCount":4064,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensChymotrypsin C, also known as  caldecrin or elastase 4, is an enzyme that in humans is encoded by the CTRC gene.[5][6]Function[edit]Chymotrypsin C is a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity.[5]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000162438 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062478 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ a b “Entrez Gene: chymotrypsin C (caldecrin)”.^ Tomomura A, Akiyama M, Itoh H, Yoshino I, Tomomura M, Nishii Y, Noikura T, Saheki T (May 1996). “Molecular cloning and expression of human caldecrin”. FEBS Lett. 386 (1): 26\u20138. doi:10.1016\/0014-5793(96)00377-8. PMID\u00a08635596.Further reading[edit]Freeman TC, Davies R, Calam J (1990). “Interactions of pancreatic secretory trypsin inhibitor in small intestinal juice: its hydrolysis and protection by intraluminal factors”. Clin. Chim. Acta. 195 (1\u20132): 27\u201339. doi:10.1016\/0009-8981(90)90191-T. PMID\u00a02093478.Masson E, Chen JM, Scotet V,  et\u00a0al. (2008). “Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis”. Hum. Genet. 123 (1): 83\u201391. doi:10.1007\/s00439-007-0459-3. PMID\u00a018172691. S2CID\u00a020466442.Rosendahl J, Witt H, Szmola R,  et\u00a0al. (2008). “Chymotrypsin C (CTRC) alterations that diminish activity or secretion are associated with chronic pancreatitis”. Nat. Genet. 40 (1): 78\u201382. doi:10.1038\/ng.2007.44. PMC\u00a02650829. PMID\u00a018059268.Kitahara K, Kawa S, Katsuyama Y,  et\u00a0al. (2008). “Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients”. Dis. Markers. 25 (3): 175\u201380. doi:10.1155\/2008\/426764. PMC\u00a03827802. PMID\u00a019096130.Stavridi ES, O’Malley K, Lukacs CM,  et\u00a0al. (1996). “Structural change in alpha-chymotrypsin induced by complexation with alpha 1-antichymotrypsin as seen by enhanced sensitivity to proteolysis”. Biochemistry. 35 (33): 10608\u201315. doi:10.1021\/bi9605806. PMID\u00a08718849.Gregory SG, Barlow KF, McLay KE,  et\u00a0al. (2006). “The DNA sequence and biological annotation of human chromosome 1”. Nature. 441 (7091): 315\u201321. Bibcode:2006Natur.441..315G. doi:10.1038\/nature04727. PMID\u00a016710414.Chang MC, Chang YT, Wei SC,  et\u00a0al. (2009). “Association of novel chymotrypsin C gene variations and haplotypes in patients with chronic pancreatitis in Chinese in Taiwan”. Pancreatology. 9 (3): 287\u201392. doi:10.1159\/000199437. PMID\u00a019407484. S2CID\u00a025853177.Yoshino-Yasuda I, Kobayashi K, Akiyama M,  et\u00a0al. (1998). “Caldecrin is a novel-type serine protease expressed in pancreas, but its homologue, elastase IV, is an artifact during cloning derived from caldecrin gene”. J. Biochem. 123 (3): 546\u201354. doi:10.1093\/oxfordjournals.jbchem.a021971. PMID\u00a09538241.Gerhard DS, Wagner L, Feingold EA,  et\u00a0al. (2004). “The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121\u20137. doi:10.1101\/gr.2596504. PMC\u00a0528928. PMID\u00a015489334.Harris WR, Malencik DA, Johnson CM,  et\u00a0al. (1990). “Purification and characterization of catalytic fragments of phosphorylase kinase gamma subunit missing a calmodulin-binding domain”. J. Biol. Chem. 265 (20): 11740\u20135. doi:10.1016\/S0021-9258(19)38460-1. PMID\u00a02365696.Derikx MH, Szmola R, te Morsche RH,  et\u00a0al. (2009). “Tropical calcific pancreatitis and its association with CTRC and SPINK1 (p.N34S) variants”. Eur J Gastroenterol Hepatol. 21 (8): 889\u201394. doi:10.1097\/MEG.0b013e32832183cf. PMID\u00a019404200. S2CID\u00a022812634.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2002). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Szmola R; Sahin-T\u00f3th M (2007). “Chymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: Identity with Rinderknecht’s enzyme Y”. Proc. Natl. Acad. Sci. U.S.A. 104 (27): 11227\u201332. Bibcode:2007PNAS..10411227S. doi:10.1073\/pnas.0703714104. PMC\u00a02040881. PMID\u00a017592142.Brecher AS, Yang MP (1998). “Acetaldehyde inhibits chymotrypsin and serum anti-chymotrypsin activity”. J. Investig. Med. 46 (4): 146\u201352. PMID\u00a09635374.  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