[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/clic4-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/clic4-wikipedia\/","headline":"CLIC4 – Wikipedia","name":"CLIC4 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Chloride intracellular channel 4, also known","datePublished":"2021-06-07","dateModified":"2021-06-07","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/9\/94\/PDB_2ahe_EBI.png\/180px-PDB_2ahe_EBI.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/9\/94\/PDB_2ahe_EBI.png\/180px-PDB_2ahe_EBI.png","height":"135","width":"180"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/clic4-wikipedia\/","about":["Wiki"],"wordCount":5762,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensChloride intracellular channel 4, also known as CLIC4, is a eukaryotic gene.[5]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits an intracellular vesicular pattern in PANC-1 cells (pancreatic cancer cells).[5]Table of ContentsBinding partners[edit]See also[edit]References[edit]Further reading[edit]External links[edit]Binding partners[edit]CLIC4 binds to dynamin I, \u03b1-tubulin, \u03b2-actin, creatine kinase and two 14-3-3 isoforms.[6]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4See also[edit]References[edit]Further reading[edit]Berryman M, Bretscher A (2000). “Identification of a Novel Member of the Chloride Intracellular Channel Gene Family (CLIC5) That Associates with the Actin Cytoskeleton of Placental Microvilli”. Mol. Biol. Cell. 11 (5): 1509\u201321. doi:10.1091\/mbc.11.5.1509. PMC\u00a014863. PMID\u00a010793131.Berryman MA, Goldenring JR (2004). “CLIC4 is enriched at cell-cell junctions and colocalizes with AKAP350 at the centrosome and midbody of cultured mammalian cells”. Cell Motil. Cytoskeleton. 56 (3): 159\u201372. doi:10.1002\/cm.10141. PMID\u00a014569596.Bohman S, Matsumoto T, Suh K,  et\u00a0al. (2006). “Proteomic analysis of vascular endothelial growth factor-induced endothelial cell differentiation reveals a role for chloride intracellular channel 4 (CLIC4) in tubular morphogenesis”. J. Biol. Chem. 280 (51): 42397\u2013404. doi:10.1074\/jbc.M506724200. PMID\u00a016239224.Chuang JZ, Milner TA, Zhu M, Sung CH (1999). “A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons”. J. Neurosci. 19 (8): 2919\u201328. doi:10.1523\/JNEUROSCI.19-08-02919.1999. PMC\u00a06782274. PMID\u00a010191309.Duncan RR, Westwood PK, Boyd A, Ashley RH (1997). “Rat brain p64H1, expression of a new member of the p64 chloride channel protein family in endoplasmic reticulum”. J. Biol. Chem. 272 (38): 23880\u20136. doi:10.1074\/jbc.272.38.23880. PMID\u00a09295337.Edwards JC (1999). “A novel p64-related Cl\u2212 channel: subcellular distribution and nephron segment-specific expression”. Am. J. Physiol. 276 (3 Pt 2): F398\u2013408. doi:10.1152\/ajprenal.1999.276.3.F398. PMID\u00a010070163. S2CID\u00a019105320.Qian Z, Okuhara D, Abe MK, Rosner MR (1999). “Molecular cloning and characterization of a mitogen-activated protein kinase-associated intracellular chloride channel”. J. Biol. Chem. 274 (3): 1621\u20137. doi:10.1074\/jbc.274.3.1621. PMID\u00a09880541.Gerhard DS, Wagner L, Feingold EA,  et\u00a0al. (2004). “The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121\u20137. doi:10.1101\/gr.2596504. PMC\u00a0528928. PMID\u00a015489334.Hartley JL, Temple GF, Brasch MA (2001). “DNA Cloning Using In Vitro Site-Specific Recombination”. Genome Res. 10 (11): 1788\u201395. doi:10.1101\/gr.143000. PMC\u00a0310948. PMID\u00a011076863.Ota T, Suzuki Y, Nishikawa T,  et\u00a0al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40\u20135. doi:10.1038\/ng1285. PMID\u00a014702039.R\u00f8nnov-Jessen L, Villadsen R, Edwards JC, Petersen OW (2002). “Differential Expression of a Chloride Intracellular Channel Gene, CLIC4, in Transforming Growth Factor-\u03b21-Mediated Conversion of Fibroblasts to Myofibroblasts”. Am. J. Pathol. 161 (2): 471\u201380. doi:10.1016\/S0002-9440(10)64203-4. PMC\u00a01850723. PMID\u00a012163372.Rual JF, Venkatesan K, Hao T,  et\u00a0al. (2005). “Towards a proteome-scale map of the human protein-protein interaction network”. Nature. 437 (7062): 1173\u20138. Bibcode:2005Natur.437.1173R. doi:10.1038\/nature04209. PMID\u00a016189514. S2CID\u00a04427026.Shiio Y, Suh KS, Lee H,  et\u00a0al. (2006). “Quantitative proteomic analysis of myc-induced apoptosis: a direct role for Myc induction of the mitochondrial chloride ion channel, mtCLIC\/CLIC4”. J. Biol. Chem. 281 (5): 2750\u20136. doi:10.1074\/jbc.M509349200. PMID\u00a016316993.Simpson JC, Wellenreuther R, Poustka A,  et\u00a0al. (2001). “Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing”. EMBO Rep. 1 (3): 287\u201392. doi:10.1093\/embo-reports\/kvd058. PMC\u00a01083732. PMID\u00a011256614.Singh H, Ashley RH (2007). “CLIC4 (p64H1) and its putative transmembrane domain form poorly selective, redox-regulated ion channels”. Mol. Membr. Biol. 24 (1): 41\u201352. doi:10.1080\/09687860600927907. PMID\u00a017453412. S2CID\u00a09986497.Singh H, Cousin MA, Ashley RH (2007). “Functional reconstitution of mammalian ‘chloride intracellular channels’ CLIC1, CLIC4 and CLIC5 reveals differential regulation by cytoskeletal actin”. FEBS J. 274 (24): 6306\u20136316. doi:10.1111\/j.1742-4658.2007.06145.x. PMID\u00a018028448. S2CID\u00a022494250.Singh H (2010). “Two decades with dimorphic Chloride Intracellular Channels (CLICs)”. FEBS Letters. 584 (10): 2112\u201321. doi:10.1016\/j.febslet.2010.03.013. PMID\u00a020226783.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Suginta W, Karoulias N, Aitken A, Ashley RH (2003). “Chloride intracellular channel protein CLIC4 (p64H1) binds directly to brain dynamin I in a complex containing actin, tubulin and 14-3-3 isoforms”. Biochem. J. 359 (Pt 1): 55\u201364. doi:10.1042\/0264-6021:3590055. PMC\u00a01222121. PMID\u00a011563969.Valenzuela SM, Martin DK, Por SB,  et\u00a0al. (1997). “Molecular cloning and expression of a chloride ion channel of cell nuclei”. J. Biol. Chem. 272 (19): 12575\u201382. doi:10.1074\/jbc.272.19.12575. PMID\u00a09139710.Wick M, B\u00fcrger C, Br\u00fcsselbach S,  et\u00a0al. (1994). “Identification of serum-inducible genes: different patterns of gene regulation during G0–>S and G1–>S progression”. J. Cell Sci. 107 (1): 227\u201339. doi:10.1242\/jcs.107.1.227. PMID\u00a08175911.Wiemann S, Arlt D, Huber W,  et\u00a0al. (2004). “From ORFeome to Biology: A Functional Genomics Pipeline”. Genome Res. 14 (10B): 2136\u201344. doi:10.1101\/gr.2576704. PMC\u00a0528930. PMID\u00a015489336.Wiemann S, Weil B, Wellenreuther R,  et\u00a0al. (2001). “Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs”. Genome Res. 11 (3): 422\u201335. doi:10.1101\/gr.GR1547R. PMC\u00a0311072. PMID\u00a011230166.External links[edit]This article incorporates text from the United States National Library of Medicine, which is in the public domain.PDB gallery2ahe: Crystal structure of a soluble form of CLIC4. intercellular chloride ion channel2d2z: Crystal structure of Soluble Form Of CLIC4       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/clic4-wikipedia\/#breadcrumbitem","name":"CLIC4 – Wikipedia"}}]}]