[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/clspn-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/clspn-wikipedia\/","headline":"CLSPN – Wikipedia","name":"CLSPN – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Claspin is a protein that in humans is","datePublished":"2016-12-19","dateModified":"2016-12-19","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/clspn-wikipedia\/","about":["Wiki"],"wordCount":6004,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensClaspin is a protein that in humans is encoded by the CLSPN gene.[5][6][7]Table of ContentsFunction[edit]Interactions[edit]References[edit]External links[edit]Further reading[edit]Function[edit]Xenopus claspin is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in the presence of DNA templates in Xenopus egg extracts. The human gene appears to be the homolog Xenopus claspin and its function has not been determined.[7]Interactions[edit]CLSPN has been shown to interact with:References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000092853 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042489 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Kumagai A, Dunphy WG (Nov 2000). “Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts”. Mol Cell. 6 (4): 839\u201349. doi:10.1016\/S1097-2765(05)00092-4. PMID\u00a011090622.^ a b Chini CC, Chen J (Aug 2003). “Human claspin is required for replication checkpoint control”. J Biol Chem. 278 (32): 30057\u201362. doi:10.1074\/jbc.M301136200. PMID\u00a012766152.^ a b “Entrez Gene: CLSPN claspin homolog (Xenopus laevis)”.^ Lin SY, Li K, Stewart GS, Elledge SJ (2004). “Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation”. Proc. Natl. Acad. Sci. U.S.A. 101 (17): 6484\u20139. Bibcode:2004PNAS..101.6484L. doi:10.1073\/pnas.0401847101. PMC\u00a0404071. PMID\u00a015096610.^ a b c Ser\u00e7in O, Kemp MG (May 2011). “Characterization of functional domains in human Claspin”. Cell Cycle. 10 (10): 1599\u2013606. doi:10.4161\/cc.10.10.15562. PMC\u00a03127160. PMID\u00a021478680.^ Faustrup H, Bekker-Jensen S, Bartek J, Lukas J, Mailand N (2009). “USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin”. J. Cell Biol. 184 (1): 13\u20139. doi:10.1083\/jcb.200807137. PMC\u00a02615094. PMID\u00a019124652.External links[edit]Further reading[edit]Chini CC, Chen J (2005). “Claspin, a regulator of Chk1 in DNA replication stress pathway”. DNA Repair (Amst.). 3 (8\u20139): 1033\u20137. doi:10.1016\/j.dnarep.2004.03.001. PMID\u00a015279790.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Lin SY, Li K, Stewart GS, Elledge SJ (2004). “Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation”. Proc. Natl. Acad. Sci. U.S.A. 101 (17): 6484\u20139. Bibcode:2004PNAS..101.6484L. doi:10.1073\/pnas.0401847101. PMC\u00a0404071. PMID\u00a015096610.S\u00f8rensen CS, Sylju\u00e5sen RG, Lukas J, Bartek J (2006). “ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage”. Cell Cycle. 3 (7): 941\u20135. doi:10.4161\/cc.3.7.972. PMID\u00a015190204.Sar F, Lindsey-Boltz LA, Subramanian D,  et\u00a0al. (2004). “Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures”. J. Biol. Chem. 279 (38): 39289\u201395. doi:10.1074\/jbc.M405793200. PMID\u00a015226314.Gerhard DS, Wagner L, Feingold EA,  et\u00a0al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121\u20137. doi:10.1101\/gr.2596504. PMC\u00a0528928. PMID\u00a015489334.Clarke CA, Clarke PR (2005). “DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system”. Biochem. J. 388 (Pt 2): 705\u201312. doi:10.1042\/BJ20041966. PMC\u00a01138979. PMID\u00a015707391.Clarke CA, Bennett LN, Clarke PR (2005). “Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway”. J. Biol. Chem. 280 (42): 35337\u201345. doi:10.1074\/jbc.M506460200. PMID\u00a016123041.Chini CC, Wood J, Chen J (2006). “Chk1 is required to maintain claspin stability”. Oncogene. 25 (30): 4165\u201371. doi:10.1038\/sj.onc.1209447. PMID\u00a016501606.Gregory SG, Barlow KF, McLay KE,  et\u00a0al. (2006). “The DNA sequence and biological annotation of human chromosome 1”. Nature. 441 (7091): 315\u201321. Bibcode:2006Natur.441..315G. doi:10.1038\/nature04727. PMID\u00a016710414.Bennett LN, Clarke PR (2006). “Regulation of Claspin degradation by the ubiquitin-proteosome pathway during the cell cycle and in response to ATR-dependent checkpoint activation”. FEBS Lett. 580 (17): 4176\u201381. doi:10.1016\/j.febslet.2006.06.071. PMID\u00a016828751.Liu S, Bekker-Jensen S, Mailand N,  et\u00a0al. (2006). “Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation”. Mol. Cell. Biol. 26 (16): 6056\u201364. doi:10.1128\/MCB.00492-06. PMC\u00a01592810. PMID\u00a016880517.Mailand N, Bekker-Jensen S, Bartek J, Lukas J (2006). “Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress”. Mol. Cell. 23 (3): 307\u201318. doi:10.1016\/j.molcel.2006.06.016. PMID\u00a016885021.Peschiaroli A, Dorrello NV, Guardavaccaro D,  et\u00a0al. (2006). “SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response”. Mol. Cell. 23 (3): 319\u201329. doi:10.1016\/j.molcel.2006.06.013. PMID\u00a016885022.Mamely I, van Vugt MA, Smits VA,  et\u00a0al. (2006). “Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery”. Curr. Biol. 16 (19): 1950\u20135. doi:10.1016\/j.cub.2006.08.026. PMID\u00a016934469.Rodr\u00edguez-Bravo V, Guaita-Esteruelas S, Florensa R,  et\u00a0al. (2007). “Chk1- and claspin-dependent but ATR\/ATM- and Rad17-independent DNA replication checkpoint response in HeLa cells”. Cancer Res. 66 (17): 8672\u20139. doi:10.1158\/0008-5472.CAN-05-4443. PMID\u00a016951182.Chini CC, Chen J (2006). “Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function”. J. Biol. Chem. 281 (44): 33276\u201382. doi:10.1074\/jbc.M604373200. PMID\u00a016963448.Sercin O, Kemp MG (2011). “Characterization of functional domains in human Claspin”. Cell Cycle. 10 (10): 1599\u2013606. doi:10.4161\/cc.10.10.15562. PMC\u00a03127160. PMID\u00a021478680.  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/clspn-wikipedia\/#breadcrumbitem","name":"CLSPN – Wikipedia"}}]}]