[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/cop9-signalosome-complex-subunit-3\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/cop9-signalosome-complex-subunit-3\/","headline":"COP9 signalosome complex subunit 3","name":"COP9 signalosome complex subunit 3","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens COP9 signalosome complex subunit 3 is a protein","datePublished":"2017-09-05","dateModified":"2017-09-05","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/cop9-signalosome-complex-subunit-3\/","wordCount":5299,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensCOP9 signalosome complex subunit 3 is a protein that in humans is encoded by the COPS3 gene.[5][6][7] It encodes a subunit of the COP9 signalosome.The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I-kappa-B-alpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17.[7]Table of ContentsSee also[edit]References[edit]External links[edit]Further reading[edit]See also[edit]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000141030 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019373 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W (Apr 1998). “A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits”. FASEB J. 12 (6): 469\u201378. doi:10.1096\/fasebj.12.6.469. PMID\u00a09535219. S2CID\u00a025424324.^ Potocki L, Chen KS, Lupski JR (Jun 1999). “Subunit 3 of the COP9 signal transduction complex is conserved from plants to humans and maps within the smith-magenis syndrome critical region in 17p11.2”. Genomics. 57 (1): 180\u20132. doi:10.1006\/geno.1998.5748. PMID\u00a010191102.^ a b “Entrez Gene: COPS3 COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)”.External links[edit]Further reading[edit]Wolf DA, Zhou C, Wee S (2004). “The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?”. Nat. Cell Biol. 5 (12): 1029\u201333. doi:10.1038\/ncb1203-1029. PMID\u00a014647295. S2CID\u00a037458780.van Dartel M, Hulsebos TJ (2004). “Amplification and overexpression of genes in 17p11.2 ~ p12 in osteosarcoma”. Cancer Genet. Cytogenet. 153 (1): 77\u201380. doi:10.1016\/j.cancergencyto.2004.03.007. PMID\u00a015325100.Wei N, Tsuge T, Serino G,  et\u00a0al. (1998). “The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex”. Curr. Biol. 8 (16): 919\u201322. doi:10.1016\/S0960-9822(07)00372-7. PMID\u00a09707402. S2CID\u00a013873982.Bianchi E, Denti S, Granata A,  et\u00a0al. (2000). “Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity”. Nature. 404 (6778): 617\u201321. Bibcode:2000Natur.404..617B. doi:10.1038\/35007098. PMID\u00a010766246. S2CID\u00a04384395.Tsuge T, Matsui M, Wei N (2001). “The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain”. J. Mol. Biol. 305 (1): 1\u20139. doi:10.1006\/jmbi.2000.4288. PMID\u00a011114242.Bech-Otschir D, Kraft R, Huang X,  et\u00a0al. (2001). “COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system”. EMBO J. 20 (7): 1630\u20139. doi:10.1093\/emboj\/20.7.1630. PMC\u00a0145508. PMID\u00a011285227.Lyapina S, Cope G, Shevchenko A,  et\u00a0al. (2001). “Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome”. Science. 292 (5520): 1382\u20135. Bibcode:2001Sci…292.1382L. doi:10.1126\/science.1059780. PMID\u00a011337588. S2CID\u00a014224920.Hong X, Xu L, Li X,  et\u00a0al. (2001). “CSN3 interacts with IKKgamma and inhibits TNF- but not IL-1-induced NF-kappaB activation”. FEBS Lett. 499 (1\u20132): 133\u20136. doi:10.1016\/S0014-5793(01)02535-2. PMID\u00a011418127. S2CID\u00a085296851.Bi W, Yan J, Stankiewicz P,  et\u00a0al. (2002). “Genes in a Refined Smith-Magenis Syndrome Critical Deletion Interval on Chromosome 17p11.2 and the Syntenic Region of the Mouse”. Genome Res. 12 (5): 713\u201328. doi:10.1101\/gr.73702. PMC\u00a0186594. PMID\u00a011997338.Hoareau Alves K, Bochard V, R\u00e9ty S, Jalinot P (2002). “Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome”. FEBS Lett. 527 (1\u20133): 15\u201321. doi:10.1016\/S0014-5793(02)03147-2. PMID\u00a012220626. S2CID\u00a039308598.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Petersen HH, Hilpert J, Militz D,  et\u00a0al. (2003). “Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule”. J. Cell Sci. 116 (Pt 3): 453\u201361. doi:10.1242\/jcs.00243. PMID\u00a012508107.Serino G, Su H, Peng Z,  et\u00a0al. (2003). “Characterization of the Last Subunit of the Arabidopsis COP9 Signalosome: Implications for the Overall Structure and Origin of the Complex”. Plant Cell. 15 (3): 719\u201331. doi:10.1105\/tpc.009092. PMC\u00a0150025. PMID\u00a012615944.Yuryev A, Wennogle LP (2003). “Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis”. Genomics. 81 (2): 112\u201325. doi:10.1016\/S0888-7543(02)00008-3. PMID\u00a012620389.Uhle S, Medalia O, Waldron R,  et\u00a0al. (2003). “Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome”. EMBO J. 22 (6): 1302\u201312. doi:10.1093\/emboj\/cdg127. PMC\u00a0151059. PMID\u00a012628923.Gevaert K, Goethals M, Martens L,  et\u00a0al. (2004). “Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides”. Nat. Biotechnol. 21 (5): 566\u20139. doi:10.1038\/nbt810. PMID\u00a012665801. S2CID\u00a023783563.Groisman R, Polanowska J, Kuraoka I,  et\u00a0al. (2003). “The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage”. Cell. 113 (3): 357\u201367. doi:10.1016\/S0092-8674(03)00316-7. PMID\u00a012732143. S2CID\u00a011639677.Henriksen J, Aagesen TH, Maelandsmo GM,  et\u00a0al. (2003). “Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation”. Oncogene. 22 (34): 5358\u201361. doi:10.1038\/sj.onc.1206671. PMID\u00a012917637.  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/cop9-signalosome-complex-subunit-3\/#breadcrumbitem","name":"COP9 signalosome complex subunit 3"}}]}]