[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/cox6c-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/cox6c-wikipedia\/","headline":"COX6C – Wikipedia","name":"COX6C – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Cytochrome c oxidase subunit 6C is","datePublished":"2021-02-25","dateModified":"2021-02-25","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/cox6c-wikipedia\/","wordCount":2922,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensCytochrome c oxidase subunit 6C is an enzyme that in humans is encoded by the COX6C gene.[4][5]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse COX subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene COX6CP1 has been found on chromosomes 16p12.[5]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000164919 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Hofmann S, Lichtner P, Schuffenhauer S, Gerbitz KD, Meitinger T (Mar 1999). “Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22\u2192q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14\u2192q21 by FISH and radiation hybrid mapping”. Cytogenet Cell Genet. 83 (3\u20134): 226\u20137. doi:10.1159\/000015185. PMID\u00a010072584.^ a b “Entrez Gene: COX6C cytochrome c oxidase subunit VIc”.External links[edit]Further reading[edit]Lenka N, Vijayasarathy C, Mullick J, Avadhani NG (1998). “Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex”. Prog. Nucleic Acid Res. Mol. Biol. Progress in Nucleic Acid Research and Molecular Biology. 61: 309\u201344. doi:10.1016\/S0079-6603(08)60830-2. ISBN\u00a09780125400619. PMID\u00a09752724.Sirchia R, Luparello C (2007). “Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells”. Biol. Chem. 388 (5): 457\u201365. doi:10.1515\/BC.2007.059. PMID\u00a017516841. S2CID\u00a02286919.Ewing RM, Chu P, Elisma F,  et\u00a0al. (2007). “Large-scale mapping of human protein-protein interactions by mass spectrometry”. Mol. Syst. Biol. 3 (1): 89. doi:10.1038\/msb4100134. PMC\u00a01847948. PMID\u00a017353931.Gerhard DS, Wagner L, Feingold EA,  et\u00a0al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121\u20137. doi:10.1101\/gr.2596504. PMC\u00a0528928. PMID\u00a015489334.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Kish SJ, Mastrogiacomo F, Guttman M,  et\u00a0al. (1999). “Decreased brain protein levels of cytochrome oxidase subunits in Alzheimer’s disease and in hereditary spinocerebellar ataxia disorders: a nonspecific change?”. J. Neurochem. 72 (2): 700\u20137. doi:10.1046\/j.1471-4159.1999.0720700.x. PMID\u00a09930743. S2CID\u00a032587972.Wang FL, Wang Y, Wong WK,  et\u00a0al. (1996). “Two differentially expressed genes in normal human prostate tissue and in carcinoma”. Cancer Res. 56 (16): 3634\u20137. PMID\u00a08705997.Otsuka M, Mizuno Y, Yoshida M,  et\u00a0al. (1989). “Nucleotide sequence of cDNA encoding human cytochrome c oxidase subunit VIc”. Nucleic Acids Res. 16 (22): 10916. doi:10.1093\/nar\/16.22.10916. PMC\u00a0338951. PMID\u00a02849755.       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