[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/cyclic-nucleotide-gated-channel-alpha-1\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/cyclic-nucleotide-gated-channel-alpha-1\/","headline":"Cyclic nucleotide-gated channel alpha 1","name":"Cyclic nucleotide-gated channel alpha 1","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens CNGA1 Identifiers Aliases CNGA1, CNCG, CNCG1, CNG-1, CNG1,","datePublished":"2021-02-02","dateModified":"2021-02-02","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/cyclic-nucleotide-gated-channel-alpha-1\/","about":["Wiki"],"wordCount":6573,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensCNGA1IdentifiersAliasesCNGA1, CNCG, CNCG1, CNG-1, CNG1, RCNC1, RCNCa, RCNCalpha, RP49, Cyclic nucleotide-gated channel alpha 1, cyclic nucleotide gated channel alpha 1, cyclic nucleotide gated channel subunit alpha 1External IDsOMIM: 123825 MGI: 88436 HomoloGene: 55432 GeneCards: CNGA1 WikidataCyclic nucleotide-gated channel alpha 1, also known as CNGA1, is a human gene encoding an ion channel protein.[5] Heterologously expressed CNGA1 can form a functional channel that is permeable to calcium.[6] In rod photoreceptors, however, CNGA1 forms a heterotetramer with CNGB1 in a 3:1 ratio.[7][8][9] The addition of the CNGB1 channel imparts altered properties including more rapid channel kinetics and greater cAMP-activated current.[10] When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1\/B1 channels and, therefore, hyperpolarization of the membrane potential.Table of ContentsSee also[edit]References[edit]Further reading[edit]External links[edit]See also[edit]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000198515 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067220 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Entrez Gene: CNGA1 cyclic nucleotide gated channel alpha 1”. Ncbi.nlm.nih.gov. Retrieved 2016-08-02.^ Kaupp, U. Benjamin; Niidome, Tetsuhiro; Tanabe, Tsutomu; Terada, Shoichi; B\u00f6nigk, Wolfgang; St\u00fchmer, Walter; Cook, Neil J.; Kangawa, Kenji; Matsuo, Hisayuki (December 1989). “Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel”. Nature. 342 (6251): 762\u2013766. Bibcode:1989Natur.342..762K. doi:10.1038\/342762a0. hdl:11858\/00-001M-0000-002B-B7A4-3. ISSN\u00a00028-0836. PMID\u00a02481236. S2CID\u00a04254661.^ Zheng, Jie; Trudeau, Matthew C.; Zagotta, William N. (December 2002). “Rod Cyclic Nucleotide-Gated Channels Have a Stoichiometry of Three CNGA1 Subunits and One CNGB1 Subunit”. Neuron. 36 (5): 891\u2013896. doi:10.1016\/s0896-6273(02)01099-1. ISSN\u00a00896-6273. PMID\u00a012467592. S2CID\u00a015365006.^ Zhong, Haining; Molday, Laurie L.; Molday, Robert S.; Yau, King-Wai (November 2002). “The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry”. Nature. 420 (6912): 193\u2013198. Bibcode:2002Natur.420..193Z. doi:10.1038\/nature01201. ISSN\u00a00028-0836. PMC\u00a02877395. PMID\u00a012432397.^ Weitz, Dietmar; Ficek, Nicole; Kremmer, Elisabeth; Bauer, Paul J.; Kaupp, U.Benjamin (December 2002). “Subunit Stoichiometry of the CNG Channel of Rod Photoreceptors”. Neuron. 36 (5): 881\u2013889. doi:10.1016\/s0896-6273(02)01098-x. ISSN\u00a00896-6273. PMID\u00a012467591. S2CID\u00a017176092.^ Chen, T.-Y.; Peng, Y.-W.; Dhallan, R. S.; Ahamed, B.; Reed, R. R.; Yau, K.-W. (April 1993). “A new subunit of the cyclic nucleotide-gated cation channel in retinal rods”. Nature. 362 (6422): 764\u2013767. Bibcode:1993Natur.362..764C. doi:10.1038\/362764a0. ISSN\u00a00028-0836. PMID\u00a07682292. S2CID\u00a04350775.Further reading[edit]Hofmann F, Biel M, Kaupp UB (December 2005). “International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels”. Pharmacological Reviews. 57 (4): 455\u201362. doi:10.1124\/pr.57.4.8. PMID\u00a016382102. S2CID\u00a045853869.Pittler SJ, Lee AK, Altherr MR, Howard TA, Seldin MF, Hurwitz RL, Wasmuth JJ, Baehr W (March 1992). “Primary structure and chromosomal localization of human and mouse rod photoreceptor cGMP-gated cation channel”. The Journal of Biological Chemistry. 267 (9): 6257\u201362. doi:10.1016\/S0021-9258(18)42689-0. PMID\u00a01372902.Arsenault TV, Sauder DN, Harley CB, McKenzie RC (March 1992). “Identification and characterization of a partial cDNA expressing interleukin-1-like activity in keratinocytes”. Molecular Immunology. 29 (3): 431\u20138. doi:10.1016\/0161-5890(92)90031-R. PMID\u00a01372959.Dhallan RS, Macke JP, Eddy RL, Shows TB, Reed RR, Yau KW, Nathans J (August 1992). “Human rod photoreceptor cGMP-gated channel: amino acid sequence, gene structure, and functional expression”. The Journal of Neuroscience. 12 (8): 3248\u201356. doi:10.1523\/JNEUROSCI.12-08-03248.1992. PMC\u00a06575660. PMID\u00a01379636.Dryja TP, Finn JT, Peng YW, McGee TL, Berson EL, Yau KW (October 1995). “Mutations in the gene encoding the alpha subunit of the rod cGMP-gated channel in autosomal recessive retinitis pigmentosa”. Proceedings of the National Academy of Sciences of the United States of America. 92 (22): 10177\u201381. Bibcode:1995PNAS…9210177D. doi:10.1073\/pnas.92.22.10177. PMC\u00a040759. PMID\u00a07479749.Distler M, Biel M, Flockerzi V, Hofmann F (November 1994). “Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells” (PDF). Neuropharmacology. 33 (11): 1275\u201382. doi:10.1016\/0028-3908(94)90027-2. PMID\u00a07532814. S2CID\u00a035784152.Griffin CA, Ding CL, Jabs EW, Hawkins AL, Li X, Levine MA (April 1993). “Human rod cGMP-gated cation channel gene maps to 4p12–>centromere by chromosomal in situ hybridization”. Genomics. 16 (1): 302\u20133. doi:10.1006\/geno.1993.1187. PMID\u00a07683629.Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M (September 1996). “Generation and analysis of 280,000 human expressed sequence tags”. Genome Research. 6 (9): 807\u201328. doi:10.1101\/gr.6.9.807. PMID\u00a08889549.Paloma E, Mart\u00ednez-Mir A, Garc\u00eda-Sandoval B, Ayuso C, Vilageliu L, Gonz\u00e0lez-Duarte R, Balcells S (October 2002). “Novel homozygous mutation in the alpha subunit of the rod cGMP gated channel (CNGA1) in two Spanish sibs affected with autosomal recessive retinitis pigmentosa”. Journal of Medical Genetics. 39 (10): 66e\u201366. doi:10.1136\/jmg.39.10.e66. PMC\u00a01734976. PMID\u00a012362048.Cheng CH, Yew DT, Kwan HY, Zhou Q, Huang Y, Liu Y, Chan WY, Yao X (October 2002). “An endogenous RNA transcript antisense to CNG(alpha)1 cation channel mRNA”. Molecular Biology of the Cell. 13 (10): 3696\u2013705. doi:10.1091\/mbc.E02-03-0127. PMC\u00a0129976. PMID\u00a012388767.Zhong H, Molday LL, Molday RS, Yau KW (November 2002). “The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry”. Nature. 420 (6912): 193\u20138. Bibcode:2002Natur.420..193Z. doi:10.1038\/nature01201. PMC\u00a02877395. PMID\u00a012432397.Zheng J, Trudeau MC, Zagotta WN (December 2002). “Rod cyclic nucleotide-gated channels have a stoichiometry of three CNGA1 subunits and one CNGB1 subunit”. Neuron. 36 (5): 891\u20136. doi:10.1016\/S0896-6273(02)01099-1. PMID\u00a012467592. S2CID\u00a015365006.Kang K, Bauer PJ, Kinjo TG, Szerencsei RT, B\u00f6nigk W, Winkfein RJ, Schnetkamp PP (April 2003). “Assembly of retinal rod or cone Na(+)\/Ca(2+)-K(+) exchanger oligomers with cGMP-gated channel subunits as probed with heterologously expressed cDNAs” (PDF). Biochemistry. 42 (15): 4593\u2013600. doi:10.1021\/bi027276z. PMID\u00a012693957.Zhang Q, Zulfiqar F, Riazuddin SA, Xiao X, Ahmad Z, Riazuddin S, Hejtmancik JF (November 2004). “Autosomal recessive retinitis pigmentosa in a Pakistani family mapped to CNGA1 with identification of a novel mutation”. Molecular Vision. 10: 884\u20139. PMID\u00a015570217.Shi F, Perez E, Wang T, Peitz B, Lapolt PS (2005). “Stage- and cell-specific expression of soluble guanylyl cyclase alpha and beta subunits, cGMP-dependent protein kinase I alpha and beta, and cyclic nucleotide-gated channel subunit 1 in the rat testis”. Journal of Andrology. 26 (2): 258\u201363. doi:10.1002\/j.1939-4640.2005.tb01093.x. PMID\u00a015713832.External links[edit]This article incorporates text from the United States National Library of Medicine, which is in the public domain.  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/cyclic-nucleotide-gated-channel-alpha-1\/#breadcrumbitem","name":"Cyclic nucleotide-gated channel alpha 1"}}]}]