[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/ddb1-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/ddb1-wikipedia\/","headline":"DDB1 – Wikipedia","name":"DDB1 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens DDB1 Available structures PDB Ortholog search:","datePublished":"2022-09-11","dateModified":"2022-09-11","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/b\/b8\/Protein_DDB1_PDB_2b5l.png\/250px-Protein_DDB1_PDB_2b5l.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/b\/b8\/Protein_DDB1_PDB_2b5l.png\/250px-Protein_DDB1_PDB_2b5l.png","height":"186","width":"250"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/ddb1-wikipedia\/","about":["Wiki"],"wordCount":8898,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensDDB1Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2B5L, 2B5M, 2B5N, 2HYE, 3E0C, 3EI1, 3EI2, 3EI3, 3EI4, 3I7H, 3I7K, 3I7L, 3I7N, 3I7O, 3I7P, 3I89, 3I8C, 3I8E, 4A08, 4A09, 4A0A, 4A0B, 4A0K, 4A0L, 4A11, 4CI1, 4CI2, 4CI3, 4E54, 4E5Z, 4TZ4, 5FQD, 5HXB       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4IdentifiersAliasesDDB1, DDBA, UV-XAP1, XPCE, XPE, XPE-BF, damage specific DNA binding protein 1, WHIKERSExternal IDsOMIM: 600045 MGI: 1202384 HomoloGene: 1448 GeneCards: DDB1 WikidataDNA damage-binding protein 1 is a protein that in humans is encoded by the DDB1 gene.[5][6][7]The gene’s position is on chromosome 11q12-q13.[8]Table of Contents       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein[edit]Function[edit]Interactions[edit]References[edit]Further reading[edit]Protein[edit]The DDB1 gene encodes the large subunit of DNA damage-binding protein, a heterodimer composed of a large and a small (DDB2) subunit. DDB1 contains 1140 amino acids, amounting to a mass of 127 kDa.[8]Function[edit]As its name suggests, DDB1 was initially implicated in the process of a specific type of DNA repair known as nucleotide excision repair. Since then, researchers have found that DDB1 primarily functions as a core component of the CUL4A- and CUL4B-based E3 ubiquitin ligase complexes. DDB1 serves as a bridge or adaptor protein which interacts with dozens of proteins known as DDB1 and CUL4-associated factors (DCAFs).[9] These DCAFs are often ubiquitin ligase substrates and regulate numerous essential processes in the cell including DNA repair (DDB2), DNA replication, chromatin remodeling (Cdt2) and more.Interactions[edit]DDB1 has been shown to interact with Transcription initiation protein SPT3 homolog,[10]GCN5L2,[11]DDB2,[12][13]CUL4A,[13]CUL4B[13] and P21.[14]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000167986 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024740 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Dualan R, Brody T, Keeney S, Nichols AF, Admon A, Linn S (Feb 1996). “Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein”. Genomics. 29 (1): 62\u20139. doi:10.1006\/geno.1995.1215. PMID\u00a08530102.^ Seki N, Hayashi A, Hattori A, Kozuma S, Sasaki M, Suzuki Y, Sugano S, Muramatsu M, Saito T (Jan 2000). “cDNA cloning, tissue expression, and chromosomal assignment of a mouse gene, encoding a 127 kDa UV-damaged DNA binding protein which is defective in XPE cells”. DNA Res. 6 (5): 319\u201322. doi:10.1093\/dnares\/6.5.319. PMID\u00a010574459.^ “Entrez Gene: DDB1 damage-specific DNA binding protein 1, 127kDa”.^ a b Iovine, Barbara; Iannella, Maria Luigia; Bevilacqua, Maria Assunta (2011). “Damage-specific DNA binding protein 1 (DDB1): a protein with a wide range of functions”. The International Journal of Biochemistry & Cell Biology. Elsevier. 43 (12): 1664\u20131667. doi:10.1016\/j.biocel.2011.09.001. PMID\u00a021959250.^ Lee J (2007). “DCAFs, the Missing Link of the CUL4-DDB1 Ubiquitin Ligase”. Molecular Cell. 26 (6): 775\u2013780. doi:10.1016\/j.molcel.2007.06.001. PMID\u00a017588513.^ Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG (October 2001). “Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo”. Mol. Cell. Biol. 21 (20): 6782\u201395. doi:10.1128\/MCB.21.20.6782-6795.2001. PMC\u00a099856. PMID\u00a011564863.^ Huang J, Chen J (July 2008). “VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation”. Oncogene. 27 (29): 4056\u201364. doi:10.1038\/onc.2008.44. PMID\u00a018332868.^ Bergametti F, Sitterlin D, Transy C (July 2002). “Turnover of hepatitis B virus X protein is regulated by damaged DNA-binding complex”. J. Virol. 76 (13): 6495\u2013501. doi:10.1128\/JVI.76.13.6495-6501.2002. PMC\u00a0136256. PMID\u00a012050362.^ a b c Guerrero-Santoro J, Kapetanaki MG, Hsieh CL, Gorbachinsky I, Levine AS, Rapi\u0107-Otrin V (July 2008). “The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A”. Cancer Res. 68 (13): 5014\u201322. doi:10.1158\/0008-5472.CAN-07-6162. PMID\u00a018593899.^ Abbas T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A (September 2008). “PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex”. Genes Dev. 22 (18): 2496\u2013506. doi:10.1101\/gad.1676108. PMC\u00a02546691. PMID\u00a018794347.Further reading[edit]Chu G, Chang E (1988). “Xeroderma pigmentosum group E cells lack a nuclear factor that binds to damaged DNA”. Science. 242 (4878): 564\u20137. doi:10.1126\/science.3175673. PMID\u00a03175673.Lee TH, Elledge SJ, Butel JS (1995). “Hepatitis B virus X protein interacts with a probable cellular DNA repair protein”. J. Virol. 69 (2): 1107\u201314. doi:10.1128\/JVI.69.2.1107-1114.1995. PMC\u00a0188683. PMID\u00a07815490.Keeney S, Eker AP, Brody T,  et\u00a0al. (1994). “Correction of the DNA repair defect in xeroderma pigmentosum group E by injection of a DNA damage-binding protein” (PDF). Proc. Natl. Acad. Sci. U.S.A. 91 (9): 4053\u20136. doi:10.1073\/pnas.91.9.4053. PMC\u00a043721. PMID\u00a08171034.Keeney S, Chang GJ, Linn S (1993). “Characterization of a human DNA damage binding protein implicated in xeroderma pigmentosum E.” J. Biol. Chem. 268 (28): 21293\u2013300. doi:10.1016\/S0021-9258(19)36923-6. PMID\u00a08407967.Hwang BJ, Liao JC, Chu G (1996). “Isolation of a cDNA encoding a UV-damaged DNA binding factor defective in xeroderma pigmentosum group E cells”. Mutat. Res. 362 (1): 105\u201317. doi:10.1016\/0921-8777(95)00040-2. PMID\u00a08538642.Nichols AF, Ong P, Linn S (1996). “Mutations specific to the xeroderma pigmentosum group E Ddb- phenotype”. J. Biol. Chem. 271 (40): 24317\u201320. doi:10.1074\/jbc.271.40.24317. PMID\u00a08798680.Liu W, Nichols AF, Graham JA,  et\u00a0al. (2000). “Nuclear transport of human DDB protein induced by ultraviolet light”. J. Biol. Chem. 275 (28): 21429\u201334. doi:10.1074\/jbc.M000961200. PMID\u00a010777491.Martinez E, Palhan VB, Tjernberg A,  et\u00a0al. (2001). “Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo”. Mol. Cell. Biol. 21 (20): 6782\u201395. doi:10.1128\/MCB.21.20.6782-6795.2001. PMC\u00a099856. PMID\u00a011564863.Chen X, Zhang Y, Douglas L, Zhou P (2002). “UV-damaged DNA-binding proteins are targets of CUL-4A-mediated ubiquitination and degradation”. J. Biol. Chem. 276 (51): 48175\u201382. doi:10.1074\/jbc.M106808200. PMID\u00a011673459.Rapi\u0107-Otrin V, McLenigan MP, Bisi DC,  et\u00a0al. (2002). “Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV irradiation”. Nucleic Acids Res. 30 (11): 2588\u201398. doi:10.1093\/nar\/30.11.2588. PMC\u00a0117178. PMID\u00a012034848.Bergametti F, Sitterlin D, Transy C (2002). “Turnover of hepatitis B virus X protein is regulated by damaged DNA-binding complex”. J. Virol. 76 (13): 6495\u2013501. doi:10.1128\/JVI.76.13.6495-6501.2002. PMC\u00a0136256. PMID\u00a012050362.Bontron S, Lin-Marq N, Strubin M (2002). “Hepatitis B virus X protein associated with UV-DDB1 induces cell death in the nucleus and is functionally antagonized by UV-DDB2”. J. Biol. Chem. 277 (41): 38847\u201354. doi:10.1074\/jbc.M205722200. PMID\u00a012151405.Andrejeva J, Poole E, Young DF,  et\u00a0al. (2002). “The p127 subunit (DDB1) of the UV-DNA damage repair binding protein is essential for the targeted degradation of STAT1 by the V protein of the paramyxovirus simian virus 5”. J. Virol. 76 (22): 11379\u201386. doi:10.1128\/JVI.76.22.11379-11386.2002. PMC\u00a0136798. PMID\u00a012388698.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Groisman R, Polanowska J, Kuraoka I,  et\u00a0al. (2003). “The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage”. Cell. 113 (3): 357\u201367. doi:10.1016\/S0092-8674(03)00316-7. PMID\u00a012732143. S2CID\u00a011639677.Leupin O, Bontron S, Strubin M (2003). “Hepatitis B virus X protein and simian virus 5 V protein exhibit similar UV-DDB1 binding properties to mediate distinct activities”. J. Virol. 77 (11): 6274\u201383. doi:10.1128\/JVI.77.11.6274-6283.2003. PMC\u00a0154990. PMID\u00a012743284.Wertz IE, O’Rourke KM, Zhang Z,  et\u00a0al. (2004). “Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase” (PDF). Science. 303 (5662): 1371\u20134. doi:10.1126\/science.1093549. PMID\u00a014739464. S2CID\u00a040501515.Bouwmeester T, Bauch A, Ruffner H,  et\u00a0al. (2004). “A physical and functional map of the human TNF-alpha\/NF-kappa B signal transduction pathway”. Nat. Cell Biol. 6 (2): 97\u2013105. doi:10.1038\/ncb1086. PMID\u00a014743216. S2CID\u00a011683986.PDB gallery2b5l: Crystal Structure of DDB1 In Complex with Simian Virus 5 V Protein2b5m: Crystal Structure of DDB12b5n: Crystal Structure of the DDB1 BPB Domain2hye: Crystal Structure of the DDB1-Cul4A-Rbx1-SV5V Complex       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/ddb1-wikipedia\/#breadcrumbitem","name":"DDB1 – Wikipedia"}}]}]