[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/dgkz-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/dgkz-wikipedia\/","headline":"DGKZ – Wikipedia","name":"DGKZ – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Diacylglycerol kinase zeta is an enzyme","datePublished":"2022-06-03","dateModified":"2022-06-03","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/dgkz-wikipedia\/","wordCount":5276,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensDiacylglycerol kinase zeta is an enzyme that in humans is encoded by the DGKZ gene.[5][6]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.[6]Interactions[edit]DGKZ has been shown to interact with P110\u03b1.[7]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000149091 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040479 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Bunting M, Tang W, Zimmerman GA, McIntyre TM, Prescott SM (Jun 1996). “Molecular cloning and characterization of a novel human diacylglycerol kinase zeta”. J Biol Chem. 271 (17): 10230\u20136. doi:10.1074\/jbc.271.17.10230. PMID\u00a08626588.^ a b “Entrez Gene: DGKZ diacylglycerol kinase, zeta 104kDa”.^ Luo, Bai; Prescott Stephen M; Topham Matthew K (Oct 2003). “Protein kinase C alpha phosphorylates and negatively regulates diacylglycerol kinase zeta”. J. Biol. Chem. 278 (41): 39542\u20137. doi:10.1074\/jbc.M307153200. ISSN\u00a00021-9258. PMID\u00a012890670.Further reading[edit]Maruyama K, Sugano S (1994). “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1\u20132): 171\u20134. doi:10.1016\/0378-1119(94)90802-8. PMID\u00a08125298.Ding L, Bunting M, Topham MK,  et\u00a0al. (1997). “Alternative splicing of the human diacylglycerol kinase zeta gene in muscle”. Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5519\u201324. Bibcode:1997PNAS…94.5519D. doi:10.1073\/pnas.94.11.5519. PMC\u00a020810. PMID\u00a09159104.Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K,  et\u00a0al. (1997). “Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library”. Gene. 200 (1\u20132): 149\u201356. doi:10.1016\/S0378-1119(97)00411-3. PMID\u00a09373149.Topham MK, Bunting M, Zimmerman GA,  et\u00a0al. (1998). “Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta”. Nature. 394 (6694): 697\u2013700. Bibcode:1998Natur.394..697T. doi:10.1038\/29337. PMID\u00a09716136. S2CID\u00a0204999472.Liu Z, Chang GQ, Leibowitz SF (2001). “Diacylglycerol kinase zeta in hypothalamus interacts with long form leptin receptor. Relation to dietary fat and body weight regulation”. J. Biol. Chem. 276 (8): 5900\u20137. doi:10.1074\/jbc.M007311200. PMID\u00a011078732.Topham MK, Prescott SM (2001). “Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism”. J. Cell Biol. 152 (6): 1135\u201343. doi:10.1083\/jcb.152.6.1135. PMC\u00a02199204. PMID\u00a011257115.Hogan A, Shepherd L, Chabot J,  et\u00a0al. (2001). “Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions”. J. Biol. Chem. 276 (28): 26526\u201333. doi:10.1074\/jbc.M104156200. PMID\u00a011352924.Santos T, Carrasco S, Jones DR,  et\u00a0al. (2002). “Dynamics of diacylglycerol kinase zeta translocation in living T-cells. Study of the structural domain requirements for translocation and activity”. J. Biol. Chem. 277 (33): 30300\u20139. doi:10.1074\/jbc.M200999200. PMID\u00a012015310.Zhong XP, Hainey EA, Olenchock BA,  et\u00a0al. (2002). “Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta”. J. Biol. Chem. 277 (34): 31089\u201398. doi:10.1074\/jbc.M203818200. PMID\u00a012070163.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Zhong XP, Hainey EA, Olenchock BA,  et\u00a0al. (2003). “Enhanced T cell responses due to diacylglycerol kinase zeta deficiency”. Nat. Immunol. 4 (9): 882\u201390. doi:10.1038\/ni958. PMID\u00a012883552. S2CID\u00a027265140.Luo B, Prescott SM, Topham MK (2003). “Protein kinase C alpha phosphorylates and negatively regulates diacylglycerol kinase zeta”. J. Biol. Chem. 278 (41): 39542\u20137. doi:10.1074\/jbc.M307153200. PMID\u00a012890670.Abramovici H, Hogan AB, Obagi C,  et\u00a0al. (2004). “Diacylglycerol kinase-zeta localization in skeletal muscle is regulated by phosphorylation and interaction with syntrophins”. Mol. Biol. Cell. 14 (11): 4499\u2013511. doi:10.1091\/mbc.E03-03-0190. PMC\u00a0266768. PMID\u00a014551255.Ota T, Suzuki Y, Nishikawa T,  et\u00a0al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40\u20135. doi:10.1038\/ng1285. PMID\u00a014702039.Davidson L, Pawson AJ, L\u00f3pez de Maturana R,  et\u00a0al. (2004). “Gonadotropin-releasing hormone-induced activation of diacylglycerol kinase-zeta and its association with active c-src”. J. Biol. Chem. 279 (12): 11906\u201316. doi:10.1074\/jbc.M310784200. PMID\u00a014707140.Luo B, Prescott SM, Topham MK (2005). “Diacylglycerol kinase zeta regulates phosphatidylinositol 4-phosphate 5-kinase Ialpha by a novel mechanism”. Cell. Signal. 16 (8): 891\u20137. doi:10.1016\/j.cellsig.2004.01.010. PMID\u00a015157668.Avila-Flores A, Santos T, Rinc\u00f3n E, M\u00e9rida I (2005). “Modulation of the mammalian target of rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid”. J. Biol. Chem. 280 (11): 10091\u20139. doi:10.1074\/jbc.M412296200. PMID\u00a015632115.Los AP, Vinke FP, de Widt J,  et\u00a0al. (2006). “The retinoblastoma family proteins bind to and activate diacylglycerol kinase zeta”. J. Biol. Chem. 281 (2): 858\u201366. doi:10.1074\/jbc.M502693200. PMID\u00a016286473.Olsen JV, Blagoev B, Gnad F,  et\u00a0al. (2006). “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks”. Cell. 127 (3): 635\u201348. doi:10.1016\/j.cell.2006.09.026. PMID\u00a017081983. S2CID\u00a07827573.     (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/dgkz-wikipedia\/#breadcrumbitem","name":"DGKZ – Wikipedia"}}]}]