[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/dual-oxidase-2-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/dual-oxidase-2-wikipedia\/","headline":"Dual oxidase 2 – Wikipedia","name":"Dual oxidase 2 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Dual oxidase 2, also known as DUOX2 or","datePublished":"2016-08-12","dateModified":"2016-08-12","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/1\/18\/Schemaduoxlpo_en.png\/500px-Schemaduoxlpo_en.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/1\/18\/Schemaduoxlpo_en.png\/500px-Schemaduoxlpo_en.png","height":"259","width":"500"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/dual-oxidase-2-wikipedia\/","about":["Wiki"],"wordCount":8797,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensDual oxidase 2, also known as DUOX2 or ThOX2 (for thyroid oxidase), is an enzyme that in humans is encoded by the DUOX2 gene.[5][6] Dual oxidase is an enzyme that was first identified in the mammalian thyroid gland. In humans, two isoforms are found; hDUOX1 and hDUOX2 (this enzyme). The protein location is not exclusive to thyroid tissue; hDUOX1 is prominent in airway epithelial cells[7] and hDUOX2 in the salivary glands and gastrointestinal tract.[8][9][10]Function[edit]Investigations into reactive oxygen species (ROS) in biological systems have, until recently, focused on characterization of phagocytic cell processes. It is now well accepted that production of such species is not restricted to phagocytic cells and can occur in eukaryotic non-phagocytic cell types via NADPH oxidase (NOX) or dual oxidase (DUOX). This new family of proteins, termed the NOX\/DUOX family or NOX family of NADPH oxidases, consists of homologs to the catalytic moiety of phagocytic NADPH-oxidase, gp91phox. Members of the NOX\/DUOX family have been found throughout eukaryotic species, including invertebrates, insects, nematodes, fungi, amoeba, algae, and plants (not found in prokaryotes). These enzymes clearly demonstrate regulated production of ROS as their sole function. Genetic analyses have implicated NOX\/DUOX derived ROS in biological roles and pathological conditions including hypertension (NOX1), innate immunity (NOX2\/DUOX), otoconia formation in the inner ear (NOX3) and thyroid hormone biosynthesis (DUOX1\/2).DUOX2 is the isoform that generates H2O2 utilized by thyroid peroxidase (TPO) for the biosynthesis of thyroid hormones,[11] supported by the discovery of congenital hypothyroidism resultant from an inactivating mutation in the DUOX2 gene.[5][12]The family currently has seven members including NOX1, NOX2 (formerly known as gp91phox), NOX3, NOX4, NOX5, DUOX1 and DUOX2.This protein is known as a dual oxidase because it has both a peroxidase homology domain and a gp91phox domain.[13]Duox are also implicated in lung defence system[14] and especially in cystic fibrosis.[15][16][17]Schema of duox implication in human lung defence system  Schematic diagram of the respiratory tract antimicrobial defense system.References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000140279 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000068452 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ a b Dupuy C, Ohayon R, Valent A, No\u00ebl-Hudson MS, D\u00e8me D, Virion A (December 1999). “Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas”. J. Biol. Chem. 274 (52): 37265\u20139. doi:10.1074\/jbc.274.52.37265. PMID\u00a010601291.^ De Deken X, Wang D, Many MC, Costagliola S, Libert F, Vassart G, Dumont JE, Miot F (July 2000). of Two Human Thyroid cDNAs Encoding New Members of the NADPH Oxidase Family.pdf “Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family” (PDF). J. Biol. Chem. 275 (30): 23227\u201333. doi:10.1074\/jbc.M000916200. PMID\u00a010806195. S2CID\u00a019424568. ^ Harper RW, Xu C, Eiserich JP, Chen Y, Kao CY, Thai P, Setiadi H, Wu R (August 2005). “Differential regulation of dual NADPH oxidases\/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium”. FEBS Lett. 579 (21): 4911\u20137. doi:10.1016\/j.febslet.2005.08.002. PMID\u00a016111680. S2CID\u00a034266530.^ Geiszt M, Witta J, Baffi J, Lekstrom K, Leto TL (August 2003). “Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense”. FASEB J. 17 (11): 1502\u20134. doi:10.1096\/fj.02-1104fje. PMID\u00a012824283. S2CID\u00a02187431.^ El Hassani RA, Benfares N, Caillou B, Talbot M, Sabourin JC, Belotte V, Morand S, Gnidehou S, Agnandji D, Ohayon R, Kaniewski J, No\u00ebl-Hudson MS, Bidart JM, Schlumberger M, Virion A, Dupuy C (May 2005). “Dual oxidase2 is expressed all along the digestive tract”. Am. J. Physiol. Gastrointest. Liver Physiol. 288 (5): G933\u201342. CiteSeerX\u00a010.1.1.334.1785. doi:10.1152\/ajpgi.00198.2004. PMID\u00a015591162.^ Rokutan K, Kawahara T, Kuwano Y, Tominaga K, Nishida K, Teshima-Kondo S (July 2008). “Nox enzymes and oxidative stress in the immunopathology of the gastrointestinal tract”. Semin Immunopathol. 30 (3): 315\u201327. doi:10.1007\/s00281-008-0124-5. PMID\u00a018521607. S2CID\u00a022923871.^ Visser, T. J. (2018). Regulation of Thyroid Function, Synthesis, and Function of Thyroid Hormones. In P. Vitti & L. Heged\u00fcs (Eds.), Thyroid Diseases Pathogenesis, Diagnosis, and Treatment. Springer. \t^ Moreno JC, Bikker H, Kempers MJ, van Trotsenburg AS, Baas F, de Vijlder JJ, Vulsma T, Ris-Stalpers C (July 2002). “Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism”. N. Engl. J. Med. 347 (2): 95\u2013102. doi:10.1056\/NEJMoa012752. PMID\u00a012110737.^ “Entrez Gene: DUOX2 dual oxidase 2”.^ Fischer H (October 2009). “Mechanisms and function of DUOX in epithelia of the lung”. Antioxid. Redox Signal. 11 (10): 2453\u201365. doi:10.1089\/ARS.2009.2558. PMC\u00a02823369. PMID\u00a019358684.^ Rada B, Lekstrom K, Damian S, Dupuy C, Leto TL (October 2008). “The Pseudomonas toxin pyocyanin inhibits the dual oxidase-based antimicrobial system as it imposes oxidative stress on airway epithelial cells”. J. Immunol. 181 (7): 4883\u201393. doi:10.4049\/jimmunol.181.7.4883. PMC\u00a02776642. PMID\u00a018802092.^ Conner GE, Salathe M, Forteza R (December 2002). “Lactoperoxidase and hydrogen peroxide metabolism in the airway”. Am. J. Respir. Crit. Care Med. 166 (12 Pt 2): S57\u201361. doi:10.1164\/rccm.2206018. PMID\u00a012471090.^ Rada B, Leto TL (2008). “Oxidative innate immune defenses by Nox\/Duox family NADPH oxidases”. Trends in Innate Immunity. Contrib Microbiol. Contributions to Microbiology. Vol.\u00a015. pp.\u00a0164\u201387. doi:10.1159\/000136357. ISBN\u00a0978-3-8055-8548-4. PMC\u00a02776633. PMID\u00a018511861.Further reading[edit]Lambeth JD (2002). “Nox\/Duox family of nicotinamide adenine dinucleotide (phosphate) oxidases”. Curr. Opin. Hematol. 9 (1): 11\u20137. doi:10.1097\/00062752-200201000-00003. PMID\u00a011753072. S2CID\u00a029968089.Moreno JC, Visser TJ (2007). New phenotypes in thyroid dyshormonogenesis: hypothyroidism due to DUOX2 mutations. Endocrine Development. Vol.\u00a010. pp.\u00a099\u2013117. doi:10.1159\/000106822. ISBN\u00a0978-3-8055-8075-5. PMID\u00a017684392.Dupuy C, Ohayon R, Valent A, No\u00ebl-Hudson MS, D\u00e8me D, Virion A (2000). “Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas”. J. Biol. Chem. 274 (52): 37265\u20139. doi:10.1074\/jbc.274.52.37265. PMID\u00a010601291.Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O’Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (2000). “Shotgun sequencing of the human transcriptome with ORF expressed sequence tags”. Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491\u20136. Bibcode:2000PNAS…97.3491D. doi:10.1073\/pnas.97.7.3491. PMC\u00a016267. PMID\u00a010737800.De Deken X, Wang D, Many MC, Costagliola S, Libert F, Vassart G, Dumont JE, Miot F (2000). of Two Human Thyroid cDNAs Encoding New Members of the NADPH Oxidase Family.pdf “Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family” (PDF). J. Biol. Chem. 275 (30): 23227\u201333. doi:10.1074\/jbc.M000916200. PMID\u00a010806195. S2CID\u00a019424568. Dupuy C, Pomerance M, Ohayon R, No\u00ebl-Hudson MS, D\u00e8me D, Chaaraoui M, Francon J, Virion A (2000). “Thyroid oxidase (THOX2) gene expression in the rat thyroid cell line FRTL-5”. Biochem. Biophys. Res. Commun. 277 (2): 287\u201392. doi:10.1006\/bbrc.2000.3671. PMID\u00a011032719.Caillou B, Dupuy C, Lacroix L, Nocera M, Talbot M, Ohayon R, D\u00e8me D, Bidart JM, Schlumberger M, Virion A (2001). “Expression of reduced nicotinamide adenine dinucleotide phosphate oxidase (ThoX, LNOX, Duox) genes and proteins in human thyroid tissues”. J. Clin. Endocrinol. Metab. 86 (7): 3351\u20138. doi:10.1210\/jcem.86.7.7646. PMID\u00a011443211.Edens WA, Sharling L, Cheng G, Shapira R, Kinkade JM, Lee T, Edens HA, Tang X, Sullards C, Flaherty DB, Benian GM, Lambeth JD (2001). “Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase\/peroxidase with homology to the phagocyte oxidase subunit gp91phox”. J. Cell Biol. 154 (4): 879\u201391. doi:10.1083\/jcb.200103132. PMC\u00a02196470. PMID\u00a011514595.Lacroix L, Nocera M, Mian C, Caillou B, Virion A, Dupuy C, Filetti S, Bidart JM, Schlumberger M (2002). “Expression of nicotinamide adenine dinucleotide phosphate oxidase flavoprotein DUOX genes and proteins in human papillary and follicular thyroid carcinomas”. Thyroid. 11 (11): 1017\u201323. doi:10.1089\/105072501753271699. PMID\u00a011762710.De Deken X, Wang D, Dumont JE, Miot F (2002). of ThOX Proteins as Components of the Thyroid H2O2-Generating System.pdf “Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system” (PDF). Exp. Cell Res. 273 (2): 187\u201396. doi:10.1006\/excr.2001.5444. PMID\u00a011822874. Moreno JC, Bikker H, Kempers MJ, van Trotsenburg AS, Baas F, de Vijlder JJ, Vulsma T, Ris-Stalpers C (2002). “Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism”. N. Engl. J. Med. 347 (2): 95\u2013102. doi:10.1056\/NEJMoa012752. PMID\u00a012110737.Geiszt M, Witta J, Baffi J, Lekstrom K, Leto TL (2003). “Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense”. FASEB J. 17 (11): 1502\u20134. doi:10.1096\/fj.02-1104fje. PMID\u00a012824283. S2CID\u00a02187431.Pachucki J, Wang D, Christophe D, Miot F (2004). “Structural and functional characterization of the two human ThOX\/Duox genes and their 5′-flanking regions”. Mol. Cell. Endocrinol. 214 (1\u20132): 53\u201362. doi:10.1016\/j.mce.2003.11.026. PMID\u00a015062544. S2CID\u00a013241525.Morand S, Agnandji D, Noel-Hudson MS, Nicolas V, Buisson S, Macon-Lemaitre L, Gnidehou S, Kaniewski J, Ohayon R, Virion A, Dupuy C (2004). “Targeting of the dual oxidase 2 N-terminal region to the plasma membrane”. J. Biol. Chem. 279 (29): 30244\u201351. doi:10.1074\/jbc.M405406200. PMID\u00a015150274.Schwarzer C, Machen TE, Illek B, Fischer H (2004). “NADPH oxidase-dependent acid production in airway epithelial cells”. J. Biol. Chem. 279 (35): 36454\u201361. doi:10.1074\/jbc.M404983200. PMID\u00a015210697.Wang D, De Deken X, Milenkovic M, Song Y, Pirson I, Dumont JE, Miot F (2005). “Identification of a novel partner of duox: EFP1, a thioredoxin-related protein”. J. Biol. Chem. 280 (4): 3096\u2013103. doi:10.1074\/jbc.M407709200. PMID\u00a015561711.El Hassani RA, Benfares N, Caillou B, Talbot M, Sabourin JC, Belotte V, Morand S, Gnidehou S, Agnandji D, Ohayon R, Kaniewski J, No\u00ebl-Hudson MS, Bidart JM, Schlumberger M, Virion A, Dupuy C (2005). “Dual oxidase2 is expressed all along the digestive tract”. Am. J. Physiol. Gastrointest. Liver Physiol. 288 (5): G933\u201342. CiteSeerX\u00a010.1.1.334.1785. doi:10.1152\/ajpgi.00198.2004. PMID\u00a015591162.Forteza R, Salathe M, Miot F, Forteza R, Conner GE (2005). “Regulated hydrogen peroxide production by Duox in human airway epithelial cells”. Am. J. Respir. Cell Mol. Biol. 32 (5): 462\u20139. doi:10.1165\/rcmb.2004-0302OC. PMID\u00a015677770.Ameziane-El-Hassani R, Morand S, Boucher JL, Frapart YM, Apostolou D, Agnandji D, Gnidehou S, Ohayon R, No\u00ebl-Hudson MS, Francon J, Lalaoui K, Virion A, Dupuy C (2005). “Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity”. J. Biol. Chem. 280 (34): 30046\u201354. doi:10.1074\/jbc.M500516200. PMID\u00a015972824.  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/dual-oxidase-2-wikipedia\/#breadcrumbitem","name":"Dual oxidase 2 – Wikipedia"}}]}]