[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/dusp13-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/dusp13-wikipedia\/","headline":"DUSP13 – Wikipedia","name":"DUSP13 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Dual specificity phosphatase 13 is an","datePublished":"2016-11-28","dateModified":"2016-11-28","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/d\/df\/PDB_2gwo_EBI.png\/180px-PDB_2gwo_EBI.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/d\/df\/PDB_2gwo_EBI.png\/180px-PDB_2gwo_EBI.png","height":"135","width":"180"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/dusp13-wikipedia\/","wordCount":2968,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensDual specificity phosphatase 13 is an enzyme that in humans is encoded by the DUSP13  gene.[5]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Function[edit]Members of the protein tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and  differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine\/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In mouse, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined.[5]References[edit]Further reading[edit]Nakamura K, Shima H, Watanabe M,  et\u00a0al. (2000). “Molecular cloning and characterization of a novel dual-specificity protein phosphatase possibly involved in spermatogenesis”. Biochem. J. 344 Pt 3 (Pt 3): 819\u201325. doi:10.1042\/0264-6021:3440819. PMC\u00a01220704. PMID\u00a010585869.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Ota T, Suzuki Y, Nishikawa T,  et\u00a0al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40\u20135. doi:10.1038\/ng1285. PMID\u00a014702039.Deloukas P, Earthrowl ME, Grafham DV,  et\u00a0al. (2004). “The DNA sequence and comparative analysis of human chromosome 10”. Nature. 429 (6990): 375\u201381. Bibcode:2004Natur.429..375D. doi:10.1038\/nature02462. PMID\u00a015164054.Chen HH, Luche R, Wei B, Tonks NK (2004). “Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2”. J. Biol. Chem. 279 (40): 41404\u201313. doi:10.1074\/jbc.M405286200. PMID\u00a015252030.Gerhard DS, Wagner L, Feingold EA,  et\u00a0al. (2004). “The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121\u20137. doi:10.1101\/gr.2596504. PMC\u00a0528928. PMID\u00a015489334.Barrios-Rodiles M, Brown KR, Ozdamar B,  et\u00a0al. (2005). “High-throughput mapping of a dynamic signaling network in mammalian cells”. Science. 307 (5715): 1621\u20135. Bibcode:2005Sci…307.1621B. doi:10.1126\/science.1105776. PMID\u00a015761153. S2CID\u00a039457788.Rual JF, Venkatesan K, Hao T,  et\u00a0al. (2005). “Towards a proteome-scale map of the human protein-protein interaction network”. Nature. 437 (7062): 1173\u20138. Bibcode:2005Natur.437.1173R. doi:10.1038\/nature04209. PMID\u00a016189514. S2CID\u00a04427026.Kim SJ, Jeong DG, Yoon TS,  et\u00a0al. (2007). “Crystal structure of human TMDP, a testis-specific dual specificity protein phosphatase: implications for substrate specificity”. Proteins. 66 (1): 239\u201345. doi:10.1002\/prot.21197. PMID\u00a017044055. S2CID\u00a030555597.PDB gallery2gwo: crystal structure of TMDP       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x42pq5: Crystal structure of Dual specificity protein phosphatase 13 (DUSP13)       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/dusp13-wikipedia\/#breadcrumbitem","name":"DUSP13 – Wikipedia"}}]}]