[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/eloa-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/eloa-wikipedia\/","headline":"ELOA – Wikipedia","name":"ELOA – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Elongin A is a protein that","datePublished":"2014-10-19","dateModified":"2014-10-19","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/eloa-wikipedia\/","wordCount":4604,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensElongin A is a protein that in humans is encoded by the ELOA gene.[5][6][7]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Elongin A is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A\/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis and is capable of forming a stable complex with elongins B and C. The von Hippel\u2013Lindau tumor suppressor protein binds to elongins B and C and thereby inhibits transcription elongation.[7]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000011007 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028668 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Aso T, Mokady N, Haque D, Conaway RC, Conaway JW (Mar 1996). “Assignment of a human gene encoding the 110-kDa subunit of general transcription factor elongin (SIII) to chromosome 1p36.1”. Genomics. 30 (2): 393\u20134. PMID\u00a08586449.^ Aso T, Lane WS, Conaway JW, Conaway RC (Oct 1995). “Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II”. Science. 269 (5229): 1439\u201343. Bibcode:1995Sci…269.1439A. doi:10.1126\/science.7660129. PMID\u00a07660129. S2CID\u00a037649908.^ a b “ELOA elongin A [ Homo sapiens (human) ]”.Further reading[edit]Shilatifard A (1998). “Factors regulating the transcriptional elongation activity of RNA polymerase II”. FASEB J. 12 (14): 1437\u201346. doi:10.1096\/fasebj.12.14.1437. PMID\u00a09806752. S2CID\u00a017435359.Kile BT, Schulman BA, Alexander WS,  et\u00a0al. (2002). “The SOCS box: a tale of destruction and degradation”. Trends Biochem. Sci. 27 (5): 235\u201341. doi:10.1016\/S0968-0004(02)02085-6. PMID\u00a012076535.Aso T, Haque D, Fukudome K,  et\u00a0al. (1996). “A human cDNA encoding the 110-kDa A subunit of RNA polymerase II transcription factor elongin”. Gene. 168 (2): 277\u20138. doi:10.1016\/0378-1119(95)00750-4. PMID\u00a08654961.Pan G, Aso T, Greenblatt J (1997). “Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators”. J. Biol. Chem. 272 (39): 24563\u201371. doi:10.1074\/jbc.272.39.24563. PMID\u00a09305922.Ohh M, Takagi Y, Aso T,  et\u00a0al. (2000). “Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein”. J. Clin. Invest. 104 (11): 1583\u201391. doi:10.1172\/JCI8161. PMC\u00a0481054. PMID\u00a010587522.Kamura T, Burian D, Yan Q,  et\u00a0al. (2001). “Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase”. J. Biol. Chem. 276 (32): 29748\u201353. doi:10.1074\/jbc.M103093200. PMID\u00a011384984.Shaheduzzaman S, Krishnan V, Petrovic A,  et\u00a0al. (2002). “Effects of HIV-1 Nef on cellular gene expression profiles”. J. Biomed. Sci. 9 (1): 82\u201396. doi:10.1007\/BF02256581. PMID\u00a011810028.Yamazaki K, Guo L, Sugahara K,  et\u00a0al. (2002). “Identification and biochemical characterization of a novel transcription elongation factor, Elongin A3”. J. Biol. Chem. 277 (29): 26444\u201351. doi:10.1074\/jbc.M202859200. PMID\u00a011994304.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Tamura K, Miyata K, Sugahara K,  et\u00a0al. (2003). “Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain”. Biochem. Biophys. Res. Commun. 309 (1): 189\u201395. doi:10.1016\/S0006-291X(03)01556-0. PMID\u00a012943681.Stoletov KV, Terman BI (2004). “Bmx is a downstream Rap1 effector in VEGF-induced endothelial cell activation”. Biochem. Biophys. Res. Commun. 320 (1): 70\u20135. doi:10.1016\/j.bbrc.2004.05.134. PMID\u00a015207703.Beausoleil SA, Jedrychowski M, Schwartz D,  et\u00a0al. (2004). “Large-scale characterization of HeLa cell nuclear phosphoproteins”. Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130\u20135. Bibcode:2004PNAS..10112130B. doi:10.1073\/pnas.0404720101. PMC\u00a0514446. PMID\u00a015302935.Gerhard DS, Wagner L, Feingold EA,  et\u00a0al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121\u20137. doi:10.1101\/gr.2596504. PMC\u00a0528928. PMID\u00a015489334.Andersen JS, Lam YW, Leung AK,  et\u00a0al. (2005). “Nucleolar proteome dynamics”. Nature. 433 (7021): 77\u201383. Bibcode:2005Natur.433…77A. doi:10.1038\/nature03207. PMID\u00a015635413. S2CID\u00a04344740.Rual JF, Venkatesan K, Hao T,  et\u00a0al. (2005). “Towards a proteome-scale map of the human protein-protein interaction network”. Nature. 437 (7062): 1173\u20138. Bibcode:2005Natur.437.1173R. doi:10.1038\/nature04209. PMID\u00a016189514. S2CID\u00a04427026.Woo JS, Imm JH, Min CK,  et\u00a0al. (2006). “Structural and functional insights into the B30.2\/SPRY domain”. EMBO J. 25 (6): 1353\u201363. doi:10.1038\/sj.emboj.7600994. PMC\u00a01422157. PMID\u00a016498413.       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