[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/etv4-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/etv4-wikipedia\/","headline":"ETV4 – Wikipedia","name":"ETV4 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens ETS translocation variant 4 (ETV4), also","datePublished":"2015-03-11","dateModified":"2015-03-11","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/etv4-wikipedia\/","about":["Wiki"],"wordCount":4343,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensETS translocation variant 4 (ETV4), also known as polyoma enhancer activator 3 (PEA3), is a member of the PEA3 subfamily of Ets transcription factors.[5][6][7]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Table of ContentsDisease marker[edit]References[edit]Further reading[edit]External links[edit]Disease marker[edit]Two variants of a disease associated with ETV4 is Ewing Sarcoma and Extraosseous Ewing’s Sarcoma. While both are cancerous tumors, the former grows in the bones most commonly affecting the arms, legs, hips, and spine, while the later affects the soft tissue in the chest, foot, pelvis and spine.References[edit]Further reading[edit]Friedman LS, Ostermeyer EA, Lynch ED, Welcsh P, Szabo CI, Meza JE, Anderson LA, Dowd P, Lee MK, Rowell SE (Jan 1995). “22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors”. Genomics. 25 (1): 256\u201363. doi:10.1016\/0888-7543(95)80133-7. PMID\u00a07774926.Liu SH, Peng BH, Ma JT, Liu YC, Ng SY (1995). “Serum response element associated transcription factors in mouse embryos: serum response factor, YY1, and PEA3 factor”. Developmental Genetics. 16 (3): 229\u201340. doi:10.1002\/dvg.1020160303. PMID\u00a07796532.Friedman LS, Ostermeyer EA, Lynch ED, Szabo CI, Anderson LA, Dowd P, Lee MK, Rowell SE, Boyd J, King MC (Dec 1994). “The search for BRCA1”. Cancer Research. 54 (24): 6374\u201382. PMID\u00a07987831.Higashino F, Yoshida K, Fujinaga Y, Kamio K, Fujinaga K (Feb 1993). “Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: a new human member of the ets oncogene family”. Nucleic Acids Research. 21 (3): 547\u201353. doi:10.1093\/nar\/21.3.547. PMC\u00a0309151. PMID\u00a08441666.Urano F, Umezawa A, Hong W, Kikuchi H, Hata J (Feb 1996). “A novel chimera gene between EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein, in extraosseous Ewing’s sarcoma”. Biochemical and Biophysical Research Communications. 219 (2): 608\u201312. doi:10.1006\/bbrc.1996.0281. PMID\u00a08605035.Coutte L, Mont\u00e9 D, Baert J, de Launoit Y (Nov 1999). “Genomic organization of the human e1af gene,a member of Ets transcription factors”. Gene. 240 (1): 201\u20137. doi:10.1016\/S0378-1119(99)00400-X. PMID\u00a010564827.Mastrangelo T, Modena P, Tornielli S, Bullrich F, Testi MA, Mezzelani A, Radice P, Azzarelli A, Pilotti S, Croce CM, Pierotti MA, Sozzi G (Aug 2000). “A novel zinc finger gene is fused to EWS in small round cell tumor”. Oncogene. 19 (33): 3799\u2013804. doi:10.1038\/sj.onc.1203762. PMID\u00a010949935.Davidson B, Goldberg I, Gotlieb WH, Kopolovic J, Ben-Baruch G, Reich R (Apr 2003). “PEA3 is the second Ets family transcription factor involved in tumor progression in ovarian carcinoma”. Clinical Cancer Research. 9 (4): 1412\u20139. PMID\u00a012684413.Span PN, Manders P, Heuvel JJ, Beex LV, Sweep CG (May 2003). “E1AF expression levels are not associated with prognosis in human breast cancer”. Breast Cancer Research and Treatment. 79 (1): 129\u201331. doi:10.1023\/A:1023338424677. PMID\u00a012779089. S2CID\u00a06629346.Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A (Apr 2004). “The human plasma proteome: a nonredundant list developed by combination of four separate sources”. Molecular & Cellular Proteomics. 3 (4): 311\u201326. doi:10.1074\/mcp.M300127-MCP200. PMID\u00a014718574.Liu Y, Borchert GL, Phang JM (Apr 2004). “Polyoma enhancer activator 3, an ets transcription factor, mediates the induction of cyclooxygenase-2 by nitric oxide in colorectal cancer cells”. The Journal of Biological Chemistry. 279 (18): 18694\u2013700. doi:10.1074\/jbc.M308136200. PMID\u00a014976201.Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). “Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions”. Genome Research. 14 (9): 1711\u20138. doi:10.1101\/gr.2435604. PMC\u00a0515316. PMID\u00a015342556.Davidson B, Goldberg I, Tell L, Vigdorchik S, Baekelandt M, Berner A, Kristensen GB, Reich R, Kopolovic J (2004). “The clinical role of the PEA3 transcription factor in ovarian and breast carcinoma in effusions”. Clinical & Experimental Metastasis. 21 (3): 191\u20139. doi:10.1023\/B:CLIN.0000037703.37275.35. PMID\u00a015387369. S2CID\u00a022579184.Fauquette V, Perrais M, Cerulis S, Jonckheere N, Ducourouble MP, Aubert JP, Pigny P, Van Seuningen I (Feb 2005). “The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation\/differentiation balance in the cells”. The Biochemical Journal. 386 (Pt 1): 35\u201345. doi:10.1042\/BJ20040706. PMC\u00a01134764. PMID\u00a015461591.Zhu X, Jiang J, Shen H, Wang H, Zong H, Li Z, Yang Y, Niu Z, Liu W, Chen X, Hu Y, Gu J (Apr 2005). “Elevated beta1,4-galactosyltransferase I in highly metastatic human lung cancer cells. Identification of E1AF as important transcription activator”. The Journal of Biological Chemistry. 280 (13): 12503\u201316. doi:10.1074\/jbc.M413631200. PMID\u00a015611127.Takahashi A, Higashino F, Aoyagi M, Yoshida K, Itoh M, Kobayashi M, Totsuka Y, Kohgo T, Shindoh M (Feb 2005). “E1AF degradation by a ubiquitin-proteasome pathway”. Biochemical and Biophysical Research Communications. 327 (2): 575\u201380. doi:10.1016\/j.bbrc.2004.12.045. PMID\u00a015629152.Nosho K, Yoshida M, Yamamoto H, Taniguchi H, Adachi Y, Mikami M, Hinoda Y, Imai K (May 2005). “Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis”. Carcinogenesis. 26 (5): 892\u20139. CiteSeerX\u00a010.1.1.567.1603. doi:10.1093\/carcin\/bgi029. PMID\u00a015695237.External links[edit]This article incorporates text from the United States National Library of Medicine, which is in the public domain.       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