[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/fgf13-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/fgf13-wikipedia\/","headline":"FGF13 – Wikipedia","name":"FGF13 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Fibroblast growth factor 13 is a","datePublished":"2021-02-08","dateModified":"2021-02-08","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/fgf13-wikipedia\/","about":["Wiki"],"wordCount":4543,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensFibroblast growth factor 13 is a protein that in humans is encoded by the FGF13 gene.[5][6]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located to a region associated with B\u00f6rjeson-Forssman-Lehmann syndrome (BFLS), a syndromal X-linked intellectual disability, which suggests it may be a candidate gene for familial cases of the BFL syndrome. The function of this gene has not yet been determined. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.[6]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000129682 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031137 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Smallwood PM, Munoz-Sanjuan I, Tong P, Macke JP, Hendry SH, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Oct 1996). “Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development”. Proc Natl Acad Sci U S A. 93 (18): 9850\u20137. Bibcode:1996PNAS…93.9850S. doi:10.1073\/pnas.93.18.9850. PMC\u00a038518. PMID\u00a08790420.^ a b “Entrez Gene: FGF13 fibroblast growth factor 13”.Further reading[edit]Gerhard DS, Wagner L, Feingold EA,  et\u00a0al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121\u20137. doi:10.1101\/gr.2596504. PMC\u00a0528928. PMID\u00a015489334.Wittmack EK, Rush AM, Craner MJ,  et\u00a0al. (2005). “Fibroblast growth factor homologous factor 2B: association with Nav1.6 and selective colocalization at nodes of Ranvier of dorsal root axons”. J. Neurosci. 24 (30): 6765\u201375. doi:10.1523\/JNEUROSCI.1628-04.2004. PMC\u00a06729706. PMID\u00a015282281.Popovici C, Conchonaud F, Birnbaum D, Roubin R (2004). “Functional phylogeny relates LET-756 to fibroblast growth factor 9”. J. Biol. Chem. 279 (38): 40146\u201352. doi:10.1074\/jbc.M405795200. PMID\u00a015199049.Facchiano A, Russo K, Facchiano AM,  et\u00a0al. (2003). “Identification of a novel domain of fibroblast growth factor 2 controlling its angiogenic properties”. J. Biol. Chem. 278 (10): 8751\u201360. doi:10.1074\/jbc.M209936200. PMID\u00a012496262.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Schoorlemmer J, Goldfarb M (2003). “Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate activation of a stress-activated protein kinase”. J. Biol. Chem. 277 (51): 49111\u20139. doi:10.1074\/jbc.M205520200. PMC\u00a04266389. PMID\u00a012244047.Knox S, Merry C, Stringer S,  et\u00a0al. (2002). “Not all perlecans are created equal: interactions with fibroblast growth factor (FGF) 2 and FGF receptors”. J. Biol. Chem. 277 (17): 14657\u201365. doi:10.1074\/jbc.M111826200. PMID\u00a011847221.Munoz-Sanjuan I, Smallwood PM, Nathans J (2000). “Isoform diversity among fibroblast growth factor homologous factors is generated by alternative promoter usage and differential splicing”. J. Biol. Chem. 275 (4): 2589\u201397. doi:10.1074\/jbc.275.4.2589. PMID\u00a010644718.Gecz J, Baker E, Donnelly A,  et\u00a0al. (1999). “Fibroblast growth factor homologous factor 2 (FHF2): gene structure, expression and mapping to the B\u00f6rjeson-Forssman-Lehmann syndrome region in Xq26 delineated by a duplication breakpoint in a BFLS-like patient”. Hum. Genet. 104 (1): 56\u201363. doi:10.1007\/s004390050910. PMID\u00a010071193. S2CID\u00a029716695.Yao DL, Masonic K, Petullo D,  et\u00a0al. (1999). “Pretreatment with intravenous FGF-13 reduces infarct volume and ameliorates neurological deficits following focal cerebral ischemia in rats”. Brain Res. 818 (1): 140\u20136. doi:10.1016\/S0006-8993(98)01118-4. PMID\u00a09914447. S2CID\u00a023714326.Greene JM, Li YL, Yourey PA,  et\u00a0al. (1998). “Identification and characterization of a novel member of the fibroblast growth factor family”. Eur. J. Neurosci. 10 (5): 1911\u201325. doi:10.1046\/j.1460-9568.1998.00211.x. PMID\u00a09751161. S2CID\u00a026104531.AngiopoietinCNTFEGF (ErbB)FGFFGFR1FGFR2Agonists: ErsoferminFGF (1, 2 (bFGF), 3, 4, 5, 6, 7 (KGF), 8, 9, 10 (KGF2), 17, 18, 22)PaliferminRepiferminSelpercatinibSpriferminTraferminFGFR3FGFR4UnsortedHGF (c-Met)IGFLNGF (p75NTR)PDGFRET (GFL)SCF (c-Kit)TGF\u03b2TrkTrkANegative allosteric modulators: VM-902ATrkBAgonists: 3,7-DHF3,7,8,2′-THF4′-DMA-7,8-DHF7,3′-DHF7,8-DHF7,8,2′-THF7,8,3′-THFAmitriptylineBDNFBNN-20DeoxygeduninDeprenylDiosmetinDMAQ-B1HIOCLM22A-4N-AcetylserotoninNT-3NT-4Norwogonin (5,7,8-THF)R7R13TDP6TrkCVEGFOthersAdditional growth factors: AdrenomedullinColony-stimulating factors (see here instead)Connective tissue growth factor (CTGF)Ephrins (A1, A2, A3, A4, A5, B1, B2, B3)Erythropoietin (see here instead)Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)Glia maturation factor (GMF)Hepatoma-derived growth factor (HDGF)Interleukins\/T-cell growth factors (see here instead)Leukemia inhibitory factor (LIF)Macrophage-stimulating protein (MSP; HLP, HGFLP)Midkine (NEGF2)Migration-stimulating factor (MSF; PRG4)OncomodulinPituitary adenylate cyclase-activating peptide (PACAP)PleiotrophinRenalaseThrombopoietin (see here instead)Wnt signaling proteinsAdditional growth factor receptor modulators: Cerebrolysin (neurotrophin mixture)       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/fgf13-wikipedia\/#breadcrumbitem","name":"FGF13 – Wikipedia"}}]}]