[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/fgf14-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/fgf14-wikipedia\/","headline":"FGF14 – Wikipedia","name":"FGF14 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Fibroblast growth factor 14 is a","datePublished":"2015-08-05","dateModified":"2015-08-05","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/fgf14-wikipedia\/","about":["Wiki"],"wordCount":5535,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensFibroblast growth factor 14 is a biologically active protein that in humans is encoded by the FGF14 gene.[5][6][7]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene.[7]FGF14 is mainly expressed in the central nervous system and is associated with neurodegenerative diseases such as spinocerebellar ataxia (SAC27). FGF14 deficiency also impairs the maturation of cells in the hippocampus, which is possibly related to the development of schizophrenia.[8]Relationship with Alzheimer’s disease[edit]FGF14 levels are elevated in patients with Alzheimer’s disease. FGF14 messenger RNA was also found to be upregulated in Alzheimer’s patients, which suggests that it is involved in the pathogenesis of the disease, although the underlying mechanism is still unknown. Research is ongoing as to whether or not FGF14 could be used as a therapy against Alzheimer’s disease as well as other neurodegenerative diseases, by promote neural proliferation and regulating the plasticity of the synapses.References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000102466 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025551 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Smallwood PM, Munoz-Sanjuan I, Tong P, Macke JP, Hendry SH, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Oct 1996). “Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development”. Proc Natl Acad Sci U S A. 93 (18): 9850\u20137. Bibcode:1996PNAS…93.9850S. doi:10.1073\/pnas.93.18.9850. PMC\u00a038518. PMID\u00a08790420.^ Wozniak DF, Xiao M, Xu L, Yamada KA, Ornitz DM (Mar 2007). “Impaired spatial learning and defective theta burst induced LTP in mice lacking fibroblast growth factor 14”. Neurobiol Dis. 26 (1): 14\u201326. doi:10.1016\/j.nbd.2006.11.014. PMC\u00a02267915. PMID\u00a017236779.^ a b “Entrez Gene: FGF14 fibroblast growth factor 14”.^ Wang, Lusheng; Jing, Rongrong; Wang, Xing; Wang, Baohui; Guo, Keke; Zhao, Jungang; Gao, Shuang; Xu, Nuo; Xuan, Xuan (June 2021) [11 June 2021]. “A method for the expression of fibroblast growth factor 14 and assessment of its neuroprotective effect in an Alzheimer’s disease model”. Annals of Translational Medicine. 9 (12): 994. doi:10.21037\/atm-21-2492. ISSN\u00a02305-5839. PMC\u00a08267273. PMID\u00a034277794.Further reading[edit]Wang Q, Bardgett ME, Wong M,  et\u00a0al. (2002). “Ataxia and paroxysmal dyskinesia in mice lacking axonally transported FGF14”. Neuron. 35 (1): 25\u201338. doi:10.1016\/S0896-6273(02)00744-4. PMID\u00a012123606.Chumakov I, Blumenfeld M, Guerassimenko O,  et\u00a0al. (2002). “Genetic and physiological data implicating the new human gene G72 and the gene for d-amino acid oxidase in schizophrenia”. Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13675\u201380. Bibcode:2002PNAS…9913675C. doi:10.1073\/pnas.182412499. PMC\u00a0129739. PMID\u00a012364586.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.van Swieten JC, Brusse E, de Graaf BM,  et\u00a0al. (2003). “A Mutation in the Fibroblast Growth Factor 14 Gene Is Associated with Autosomal Dominant Cerebral Ataxia”. Am. J. Hum. Genet. 72 (1): 191\u20139. doi:10.1086\/345488. PMC\u00a0378625. PMID\u00a012489043.Dunham A, Matthews LH, Burton J,  et\u00a0al. (2004). “The DNA sequence and analysis of human chromosome 13”. Nature. 428 (6982): 522\u20138. Bibcode:2004Natur.428..522D. doi:10.1038\/nature02379. PMC\u00a02665288. PMID\u00a015057823.Popovici C, Conchonaud F, Birnbaum D, Roubin R (2004). “Functional phylogeny relates LET-756 to fibroblast growth factor 9”. J. Biol. Chem. 279 (38): 40146\u201352. doi:10.1074\/jbc.M405795200. PMID\u00a015199049.Stevanin G, Durr A, Dussert C,  et\u00a0al. (2005). “Mutations in the FGF14 gene are not a major cause of spinocerebellar ataxia in Caucasians”. Neurology. 63 (5): 936. doi:10.1212\/01.wnl.0000137020.30604.1e. PMID\u00a015365159. S2CID\u00a035093587.Dalski A, Atici J, Kreuz FR,  et\u00a0al. (2005). “Mutation analysis in the fibroblast growth factor 14 gene: frameshift mutation and polymorphisms in patients with inherited ataxias”. Eur. J. Hum. Genet. 13 (1): 118\u201320. doi:10.1038\/sj.ejhg.5201286. PMID\u00a015470364.Lou JY, Laezza F, Gerber BR,  et\u00a0al. (2006). “Fibroblast growth factor 14 is an intracellular modulator of voltage-gated sodium channels”. J. Physiol. 569 (Pt 1): 179\u201393. doi:10.1113\/jphysiol.2005.097220. PMC\u00a01464207. PMID\u00a016166153.Brusse E, de Koning I, Maat-Kievit A,  et\u00a0al. (2006). “Spinocerebellar ataxia associated with a mutation in the fibroblast growth factor 14 gene (SCA27): A new phenotype”. Mov. Disord. 21 (3): 396\u2013401. doi:10.1002\/mds.20708. PMID\u00a016211615. S2CID\u00a025438944.Zhao Y, Lim SW, Tan EK (2007). “Genetic analysis of SCA 27 in ataxia and childhood onset postural tremor”. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (3): 395\u20136. doi:10.1002\/ajmg.b.30472. PMID\u00a017221845. S2CID\u00a041536996.AngiopoietinCNTFEGF (ErbB)FGFFGFR1FGFR2Agonists: ErsoferminFGF (1, 2 (bFGF), 3, 4, 5, 6, 7 (KGF), 8, 9, 10 (KGF2), 17, 18, 22)PaliferminRepiferminSelpercatinibSpriferminTraferminFGFR3FGFR4UnsortedHGF (c-Met)IGFLNGF (p75NTR)PDGFRET (GFL)SCF (c-Kit)TGF\u03b2TrkTrkANegative allosteric modulators: VM-902ATrkBAgonists: 3,7-DHF3,7,8,2′-THF4′-DMA-7,8-DHF7,3′-DHF7,8-DHF7,8,2′-THF7,8,3′-THFAmitriptylineBDNFBNN-20DeoxygeduninDeprenylDiosmetinDMAQ-B1HIOCLM22A-4N-AcetylserotoninNT-3NT-4Norwogonin (5,7,8-THF)R7R13TDP6TrkCVEGFOthersAdditional growth factors: AdrenomedullinColony-stimulating factors (see here instead)Connective tissue growth factor (CTGF)Ephrins (A1, A2, A3, A4, A5, B1, B2, B3)Erythropoietin (see here instead)Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)Glia maturation factor (GMF)Hepatoma-derived growth factor (HDGF)Interleukins\/T-cell growth factors (see here instead)Leukemia inhibitory factor (LIF)Macrophage-stimulating protein (MSP; HLP, HGFLP)Midkine (NEGF2)Migration-stimulating factor (MSF; PRG4)OncomodulinPituitary adenylate cyclase-activating peptide (PACAP)PleiotrophinRenalaseThrombopoietin (see here instead)Wnt signaling proteinsAdditional growth factor receptor modulators: Cerebrolysin (neurotrophin mixture)       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/fgf14-wikipedia\/#breadcrumbitem","name":"FGF14 – Wikipedia"}}]}]