[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/fnbp1l-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/fnbp1l-wikipedia\/","headline":"FNBP1L – Wikipedia","name":"FNBP1L – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Formin-binding protein 1-like is a protein","datePublished":"2021-10-07","dateModified":"2021-10-07","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/fnbp1l-wikipedia\/","about":["Wiki"],"wordCount":4333,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensFormin-binding protein 1-like is a protein that in humans is encoded by the FNBP1L gene.[3][4]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Table of ContentsFunction[edit]Clinical significance[edit]References[edit]Further reading[edit]Function[edit]The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms.[4]Clinical significance[edit]FNBP1L polymorphisms, specifically the SNP rs236330 has been associated with normally varying intelligence differences in adults[5] and in children.[6]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000137942 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Katoh M, Katoh M (Dec 2003). “Identification and characterization of human FNBP1L gene in silico”. Int J Mol Med. 13 (1): 157\u201362. doi:10.3892\/ijmm.13.1.157. PMID\u00a014654988.^ a b “Entrez Gene: FNBP1L formin binding protein 1-like”.^ Davies G, Tenesa A, Payton A, Yang J, Harris SE, Liewald D, Ke X, Le Hellard S, Christoforou A, Luciano M, McGhee K, Lopez L, Gow AJ, Corley J, Redmond P, Fox HC, Haggarty P, Whalley LJ, McNeill G, Goddard ME, Espeseth T, Lundervold AJ, Reinvang I, Pickles A, Steen VM, Ollier W, Porteous DJ, Horan M, Starr JM, Pendleton N, Visscher PM, Deary IJ (October 2011). “Genome-wide association studies establish that human intelligence is highly heritable and polygenic”. Mol. Psychiatry. 16 (10): 996\u20131005. doi:10.1038\/mp.2011.85. PMC\u00a03182557. PMID\u00a021826061.^ Benyamin B, Pourcain B, Davis OS, Davies G, Hansell NK, Brion MJ, Kirkpatrick RM, Cents RA, Frani\u0107 S, Miller MB, Haworth CM, Meaburn E, Price TS, Evans DM, Timpson N, Kemp J, Ring S, McArdle W, Medland SE, Yang J, Harris SE, Liewald DC, Scheet P, Xiao X, Hudziak JJ, de Geus EJ, Jaddoe VW, Starr JM, Verhulst FC, Pennell C, Tiemeier H, Iacono WG, Palmer LJ, Montgomery GW, Martin NG, Boomsma DI, Posthuma D, McGue M, Wright MJ, Davey Smith G, Deary IJ, Plomin R, Visscher PM (January 2013). “Childhood intelligence is heritable, highly polygenic and associated with FNBP1L”. Mol. Psychiatry. 19 (2): 253\u20138. doi:10.1038\/mp.2012.184. PMC\u00a03935975. PMID\u00a023358156.Further reading[edit]Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Ota T, Suzuki Y, Nishikawa T,  et\u00a0al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40\u20135. doi:10.1038\/ng1285. PMID\u00a014702039.Ho HY, Rohatgi R, Lebensohn AM,  et\u00a0al. (2004). “Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex”. Cell. 118 (2): 203\u201316. doi:10.1016\/j.cell.2004.06.027. PMID\u00a015260990. S2CID\u00a015516629.Gerhard DS, Wagner L, Feingold EA,  et\u00a0al. (2004). “The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121\u20137. doi:10.1101\/gr.2596504. PMC\u00a0528928. PMID\u00a015489334.Stelzl U, Worm U, Lalowski M,  et\u00a0al. (2005). “A human protein-protein interaction network: a resource for annotating the proteome”. Cell. 122 (6): 957\u201368. doi:10.1016\/j.cell.2005.08.029. hdl:11858\/00-001M-0000-0010-8592-0. PMID\u00a016169070. S2CID\u00a08235923.Itoh T, Erdmann KS, Roux A,  et\u00a0al. (2006). “Dynamin and the actin cytoskeleton cooperatively regulate plasma membrane invagination by BAR and F-BAR proteins”. Dev. Cell. 9 (6): 791\u2013804. doi:10.1016\/j.devcel.2005.11.005. PMID\u00a016326391.Tsujita K, Suetsugu S, Sasaki N,  et\u00a0al. (2006). “Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis”. J. Cell Biol. 172 (2): 269\u201379. doi:10.1083\/jcb.200508091. PMC\u00a02063556. PMID\u00a016418535.Aspenstr\u00f6m P, Richnau N, Johansson AS (2006). “The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics”. Exp. Cell Res. 312 (12): 2180\u201394. doi:10.1016\/j.yexcr.2006.03.013. PMID\u00a016630611.Gregory SG, Barlow KF, McLay KE,  et\u00a0al. (2006). “The DNA sequence and biological annotation of human chromosome 1”. Nature. 441 (7091): 315\u201321. Bibcode:2006Natur.441..315G. doi:10.1038\/nature04727. PMID\u00a016710414.Kovacs EM, Makar RS, Gertler FB (2006). “Tuba stimulates intracellular N-WASP-dependent actin assembly”. J. Cell Sci. 119 (Pt 13): 2715\u201326. doi:10.1242\/jcs.03005. PMID\u00a016757518.Kakimoto T, Katoh H, Negishi M (2006). “Regulation of neuronal morphology by Toca-1, an F-BAR\/EFC protein that induces plasma membrane invagination”. J. Biol. Chem. 281 (39): 29042\u201353. doi:10.1074\/jbc.M604025200. PMID\u00a016885158.       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/fnbp1l-wikipedia\/#breadcrumbitem","name":"FNBP1L – Wikipedia"}}]}]