[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/fscn2-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/fscn2-wikipedia\/","headline":"FSCN2 – Wikipedia","name":"FSCN2 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Fascin-2 is a protein that in humans is","datePublished":"2015-11-22","dateModified":"2015-11-22","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/fscn2-wikipedia\/","about":["Wiki"],"wordCount":3081,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensFascin-2 is a protein that in humans is encoded by the FSCN2 gene.[5][6]This gene encodes a member of the fascin protein family. Fascins crosslink actin into filamentous bundles within dynamic cell extensions. This family member is proposed to play a role in photoreceptor disk morphogenesis. A mutation in this gene results in one form of autosomal dominant retinitis pigmentosa and macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene.[6]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000186765 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025380 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Bardien-Kruger S, Greenberg J, Tubb B, Bryan J, Queimado L, Lovett M, Ramesar RS (Jun 1999). “Refinement of the RP17 locus for autosomal dominant retinitis pigmentosa, construction of a YAC contig and investigation of the candidate gene retinal fascin”. Eur J Hum Genet. 7 (3): 332\u20138. doi:10.1038\/sj.ejhg.5200302. PMID\u00a010234509.^ a b “Entrez Gene: FSCN2 fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)”.Further reading[edit]Hillier LD, Lennon G, Becker M,  et\u00a0al. (1997). “Generation and analysis of 280,000 human expressed sequence tags”. Genome Res. 6 (9): 807\u201328. doi:10.1101\/gr.6.9.807. PMID\u00a08889549.Tubb BE, Bardien-Kruger S, Kashork CD,  et\u00a0al. (2000). “Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes”. Genomics. 65 (2): 146\u201356. doi:10.1006\/geno.2000.6156. PMID\u00a010783262.Saishin Y, Ishikawa R, Ugawa S,  et\u00a0al. (2000). “Retinal fascin: functional nature, subcellular distribution, and chromosomal localization”. Invest. Ophthalmol. Vis. Sci. 41 (8): 2087\u201395. PMID\u00a010892848.Wada Y, Abe T, Takeshita T,  et\u00a0al. (2001). “Mutation of human retinal fascin gene (FSCN2) causes autosomal dominant retinitis pigmentosa”. Invest. Ophthalmol. Vis. Sci. 42 (10): 2395\u2013400. PMID\u00a011527955.Guan Y, Woo PL, Rubenstein NM, Firestone GL (2002). “Transforming growth factor-alpha abrogates the glucocorticoid stimulation of tight junction formation and reverses the steroid-induced down-regulation of fascin in rat mammary epithelial tumor cells by a Ras-dependent pathway”. Exp. Cell Res. 273 (1): 1\u201311. doi:10.1006\/excr.2001.5415. PMID\u00a011795941.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Wada Y, Abe T, Itabashi T,  et\u00a0al. (2003). “Autosomal dominant macular degeneration associated with 208delG mutation in the FSCN2 gene”. Arch. Ophthalmol. 121 (11): 1613\u201320. doi:10.1001\/archopht.121.11.1613. PMID\u00a014609921.Gerhard DS, Wagner L, Feingold EA,  et\u00a0al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121\u20137. doi:10.1101\/gr.2596504. PMC\u00a0528928. PMID\u00a015489334.Gamundi MJ, Hernan I, Maseras M,  et\u00a0al. (2006). “Sequence variations in the retinal fascin FSCN2 gene in a Spanish population with autosomal dominant retinitis pigmentosa or macular degeneration”. Mol. Vis. 11: 922\u20138. PMID\u00a016280978.Zhang Q, Li S, Xiao X,  et\u00a0al. (2007). “The 208delG mutation in FSCN2 does not associate with retinal degeneration in Chinese individuals”. Invest. Ophthalmol. Vis. Sci. 48 (2): 530\u20133. doi:10.1167\/iovs.06-0669. PMID\u00a017251446.External links[edit]  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/fscn2-wikipedia\/#breadcrumbitem","name":"FSCN2 – Wikipedia"}}]}]