[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/fut2-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/fut2-wikipedia\/","headline":"FUT2 – Wikipedia","name":"FUT2 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein and coding gene in humans Galactoside 2-alpha-L-fucosyltransferase 2 is an enzyme that","datePublished":"2021-05-22","dateModified":"2021-05-22","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/fut2-wikipedia\/","about":["Wiki"],"wordCount":5586,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein and coding gene in humansGalactoside 2-alpha-L-fucosyltransferase 2 is an enzyme that in humans is encoded by the FUT2 gene.[5][6] It affects the secretor status of ABO antigens.[7]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Approximately 20% of Caucasians are non-secretors due to the G428A (rs601338) and C571T (rs492602?) nonsense mutations in FUT2 and therefore have strong although not absolute protection from the norovirus GII.4.[citation needed]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000176920 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055978 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Ball SP, Tongue N, Gibaud A, Le Pendu J, Mollicone R, Gerard G, Oriol R (Feb 1992). “The human chromosome 19 linkage group FUT1 (H), FUT2 (SE), LE, LU, PEPD, C3, APOC2, D19S7 and D19S9”. Ann Hum Genet. 55 (Pt 3): 225\u201333. doi:10.1111\/j.1469-1809.1991.tb00417.x. PMID\u00a01763885. S2CID\u00a030777695.^ “Entrez Gene: FUT2 fucosyltransferase 2 (secretor status included)”.^ “Names for H (ISBT 018) Blood Group Alleles” (PDF). www.isbtweb.org. Archived from the original (PDF) on 2019-08-28. Retrieved 2019-10-13.Further reading[edit]Reguigne-Arnould I; Couillin P; Mollicone R;  et\u00a0al. (1995). “Relative positions of two clusters of human alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19”. Cytogenet. Cell Genet. 71 (2): 158\u201362. doi:10.1159\/000134098. PMID\u00a07656588.Rouquier S; Lowe JB; Kelly RJ;  et\u00a0al. (1995). “Molecular cloning of a human genomic region containing the H blood group alpha(1,2)fucosyltransferase gene and two H locus-related DNA restriction fragments. Isolation of a candidate for the human Secretor blood group locus”. J. Biol. Chem. 270 (9): 4632\u20139. doi:10.1074\/jbc.270.9.4632. PMID\u00a07876234.Kelly RJ; Rouquier S; Giorgi D;  et\u00a0al. (1995). “Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype”. J. Biol. Chem. 270 (9): 4640\u20139. doi:10.1074\/jbc.270.9.4640. PMID\u00a07876235.Kudo T; Iwasaki H; Nishihara S;  et\u00a0al. (1996). “Molecular genetic analysis of the human Lewis histo-blood group system. II. Secretor gene inactivation by a novel single missense mutation A385T in Japanese nonsecretor individuals”. J. Biol. Chem. 271 (16): 9830\u20137. doi:10.1074\/jbc.271.16.9830. PMID\u00a08621666.Koda Y, Soejima M, Liu Y, Kimura H (1996). “Molecular basis for secretor type alpha(1,2)-fucosyltransferase gene deficiency in a Japanese population: a fusion gene generated by unequal crossover responsible for the enzyme deficiency”. Am. J. Hum. Genet. 59 (2): 343\u201350. PMC\u00a01914724. PMID\u00a08755920.Koda Y, Soejima M, Wang B, Kimura H (1997). “Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2)”. Eur. J. Biochem. 246 (3): 750\u20135. doi:10.1111\/j.1432-1033.1997.t01-1-00750.x. PMID\u00a09219535.Koda Y; Soejima M; Johnson PH;  et\u00a0al. (1997). “Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system”. Biochem. Biophys. Res. Commun. 238 (1): 21\u20135. doi:10.1006\/bbrc.1997.7232. PMID\u00a09299444.Liu Y; Koda Y; Soejima M;  et\u00a0al. (1998). “Extensive polymorphism of the FUT2 gene in an African (Xhosa) population of South Africa”. Hum. Genet. 103 (2): 204\u201310. doi:10.1007\/s004390050808. PMID\u00a09760207. S2CID\u00a025253767.Domino SE, Zhang L, Lowe JB (2001). “Molecular cloning, genomic mapping, and expression of two secretor blood group alpha (1,2)fucosyltransferase genes differentially regulated in mouse uterine epithelium and gastrointestinal tract”. J. Biol. Chem. 276 (26): 23748\u201356. doi:10.1074\/jbc.M100735200. PMID\u00a011323419.Roos C, Kolmer M, Mattila P, Renkonen R (2002). “Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism”. J. Biol. Chem. 277 (5): 3168\u201375. doi:10.1074\/jbc.M107927200. PMID\u00a011698403.Milland J; Russell SM; Dodson HC;  et\u00a0al. (2002). “The cytoplasmic tail of alpha 1,3-galactosyltransferase inhibits Golgi localization of the full-length enzyme”. J. Biol. Chem. 277 (12): 10374\u20138. doi:10.1074\/jbc.M111799200. PMID\u00a011777923.Chang JG; Ko YC; Lee JC;  et\u00a0al. (2002). “Molecular analysis of mutations and polymorphisms of the Lewis secretor type alpha(1,2)-fucosyltransferase gene reveals that Taiwan aborigines are of Austronesian derivation”. J. Hum. Genet. 47 (2): 60\u20135. doi:10.1007\/s100380200001. PMID\u00a011916003.Strausberg RL; Feingold EA; Grouse LH;  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Lindesmith L; Moe C; Marionneau S;  et\u00a0al. (2003). “Human susceptibility and resistance to Norwalk virus infection”. Nat. Med. 9 (5): 548\u201353. doi:10.1038\/nm860. PMID\u00a012692541. S2CID\u00a028663420.Guo ZH; Xiang D; Zhu ZY;  et\u00a0al. (2004). “[Analysis on FUT1 and FUT2 gene of 10 para-Bombay individuals in China]”. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 21 (5): 417\u201321. PMID\u00a015476160.Chen DP; Tseng CP; Wang WT;  et\u00a0al. (2005). “Two prevalent h alleles in para-Bombay haplotypes among 250,000 Taiwanese”. Ann. Clin. Lab. Sci. 34 (3): 314\u20138. PMID\u00a015487706.Pang H, Soejima M, Koda Y, Kimura H (2005). “A novel tetrameric short tandem repeat located in the 3′ flanking region of the human ABO-secretor gene (FUT2) and association between FUT2 and FUT2\/01 loci”. Hum. Biol. 76 (5): 789\u201395. doi:10.1353\/hub.2005.0008. PMID\u00a015757249. S2CID\u00a01201579.Madjd Z; Parsons T; Watson NF;  et\u00a0al. (2006). “High expression of Lewis y\/b antigens is associated with decreased survival in lymph node negative breast carcinomas”. Breast Cancer Res. 7 (5): R780\u20137. doi:10.1186\/bcr1305. PMC\u00a01242157. PMID\u00a016168124.Kimura K; Wakamatsu A; Suzuki Y;  et\u00a0al. (2006). “Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes”. Genome Res. 16 (1): 55\u201365. doi:10.1101\/gr.4039406. PMC\u00a01356129. PMID\u00a016344560.       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/fut2-wikipedia\/#breadcrumbitem","name":"FUT2 – Wikipedia"}}]}]