[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/gpr114-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/gpr114-wikipedia\/","headline":"GPR114 – Wikipedia","name":"GPR114 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens G protein-coupled receptor 114 is a","datePublished":"2015-11-11","dateModified":"2015-11-11","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/gpr114-wikipedia\/","wordCount":2946,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensG protein-coupled receptor 114 is a protein encoded by the ADGRG5 gene.[5][6][7] GPR114 is a member of the adhesion GPCR family.[8][9]Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[10]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4GPR114 mRNA is specifically expressed in human eosinophils as well as in mouse lymphocytes, monocytes, macrophage, and dendritic cells.[11]Signaling[edit]The cyclic adenosine monophosphate (cAMP) assay in overexpressing HEK293 cells has demonstrated coupling of GPR114 to G\u03b1s protein.[12]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000159618 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061577 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Entrez Gene: GPR114 G protein-coupled receptor 114”.^ Fredriksson R, Lagerstr\u00f6m MC, H\u00f6glund PJ, Schi\u00f6th HB (Nov 2002). “Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser\/Thr-rich regions”. FEBS Letters. 531 (3): 407\u201314. doi:10.1016\/S0014-5793(02)03574-3. PMID\u00a012435584. S2CID\u00a07449692.^ Hamann, J; Aust, G; Ara\u00e7, D; Engel, FB; Formstone, C; Fredriksson, R; Hall, RA; Harty, BL; Kirchhoff, C; Knapp, B; Krishnan, A; Liebscher, I; Lin, HH; Martinelli, DC; Monk, KR; Peeters, MC; Piao, X; Pr\u00f6mel, S; Sch\u00f6neberg, T; Schwartz, TW; Singer, K; Stacey, M; Ushkaryov, YA; Vallon, M; Wolfrum, U; Wright, MW; Xu, L; Langenhan, T; Schi\u00f6th, HB (April 2015). “International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors”. Pharmacological Reviews. 67 (2): 338\u201367. doi:10.1124\/pr.114.009647. PMC\u00a04394687. PMID\u00a025713288.^ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN\u00a0978-1-4419-7912-4.^ Langenhan, T; Aust, G; Hamann, J (21 May 2013). “Sticky signaling–adhesion class G protein-coupled receptors take the stage”. Science Signaling. 6 (276): re3. doi:10.1126\/scisignal.2003825. PMID\u00a023695165. S2CID\u00a06958640.^ Ara\u00e7 D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, S\u00fcdhof TC, Brunger AT (Mar 2012). “A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis”. The EMBO Journal. 31 (6): 1364\u201378. doi:10.1038\/emboj.2012.26. PMC\u00a03321182. PMID\u00a022333914.^ Hamann J, Aust G, Ara\u00e7 D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Pr\u00f6mel S, Sch\u00f6neberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schi\u00f6th HB (Apr 2015). “International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors”. Pharmacological Reviews. 67 (2): 338\u201367. doi:10.1124\/pr.114.009647. PMC\u00a04394687. PMID\u00a025713288.^ Gupte J, Swaminath G, Danao J, Tian H, Li Y, Wu X (Apr 2012). “Signaling property study of adhesion G-protein-coupled receptors”. FEBS Letters. 586 (8): 1214\u20139. doi:10.1016\/j.febslet.2012.03.014. PMID\u00a022575658. S2CID\u00a03020230.External links[edit]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/gpr114-wikipedia\/#breadcrumbitem","name":"GPR114 – Wikipedia"}}]}]