[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/gpr6-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/gpr6-wikipedia\/","headline":"GPR6 – Wikipedia","name":"GPR6 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens G protein-coupled receptor 6, also known","datePublished":"2019-11-22","dateModified":"2019-11-22","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/www.wikimedia.org\/static\/images\/wmf-logo.png","url":"https:\/\/www.wikimedia.org\/static\/images\/wmf-logo.png","height":"101","width":"135"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/gpr6-wikipedia\/","wordCount":3752,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensG protein-coupled receptor 6, also known as GPR6, is a protein which in humans is encoded by the GPR6 gene.[5][6]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Table of ContentsFunction[edit]Inverse Agonist[edit]See also[edit]References[edit]Further reading[edit]External links[edit]Function[edit]GPR6 is a member of the G protein-coupled receptor family of transmembrane receptors.  It has been reported that GPR6 is both constitutively active but in addition is further activated by sphingosine-1-phosphate.[7]GPR6 up-regulates cyclic AMP levels and promotes neurite outgrowth.[8]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Inverse Agonist[edit]See also[edit]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000146360 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046922 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Entrez Gene: GPR6 G protein-coupled receptor 6”.^ Song ZH, Modi W, Bonner TI (July 1995). “Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors”. Genomics. 28 (2): 347\u2013349. doi:10.1006\/geno.1995.1154. PMID\u00a08530049.^ Uhlenbrock K, Gassenhuber H, Kostenis E (November 2002). “Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors”. Cellular Signalling. 14 (11): 941\u2013953. doi:10.1016\/S0898-6568(02)00041-4. PMID\u00a012220620.^ Tanaka S, Ishii K, Kasai K, Yoon SO, Saeki Y (April 2007). “Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth”. The Journal of Biological Chemistry. 282 (14): 10506\u201310515. doi:10.1074\/jbc.M700911200. PMID\u00a017284443.^ Laun AS, Shrader SH, Brown KJ, Song ZH (March 2019). “GPR3, GPR6, and GPR12 as novel molecular targets: their biological functions and interaction with cannabidiol”. Acta Pharmacologica Sinica. 40 (3): 300\u2013308. doi:10.1038\/s41401-018-0031-9. PMC\u00a06460361. PMID\u00a029941868.Further reading[edit]ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}]]>Heiber M, Docherty JM, Shah G, Nguyen T, Cheng R, Heng HH,  et\u00a0al. (January 1995). “Isolation of three novel human genes encoding G protein-coupled receptors”. DNA and Cell Biology. 14 (1): 25\u201335. doi:10.1089\/dna.1995.14.25. PMID\u00a07832990.Song ZH, Modi W, Bonner TI (July 1995). “Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors”. Genomics. 28 (2): 347\u2013349. doi:10.1006\/geno.1995.1154. PMID\u00a08530049.Uhlenbrock K, Huber J, Ardati A, Busch AE, Kostenis E (2003). “Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells”. Cellular Physiology and Biochemistry. 13 (2): 75\u201384. doi:10.1159\/000070251. PMID\u00a012649592. S2CID\u00a045156405.External links[edit]“GPR6”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.li{counter-increment:listitem}.mw-parser-output .hlist ol>li::before{content:\" \"counter(listitem)\"a0 \"}.mw-parser-output .hlist dd ol>li:first-child::before,.mw-parser-output .hlist dt ol>li:first-child::before,.mw-parser-output .hlist li ol>li:first-child::before{content:\" (\"counter(listitem)\"a0 \"}]]>.navbox-abovebelow,.mw-parser-output tr+tr>.navbox-group,.mw-parser-output tr+tr>.navbox-image,.mw-parser-output tr+tr>.navbox-list{border-top:2px solid #fdfdfd}.mw-parser-output .navbox-title{background-color:#ccf}.mw-parser-output .navbox-abovebelow,.mw-parser-output .navbox-group,.mw-parser-output .navbox-subgroup .navbox-title{background-color:#ddf}.mw-parser-output .navbox-subgroup .navbox-group,.mw-parser-output .navbox-subgroup .navbox-abovebelow{background-color:#e6e6ff}.mw-parser-output .navbox-even{background-color:#f7f7f7}.mw-parser-output .navbox-odd{background-color:transparent}.mw-parser-output .navbox .hlist td dl,.mw-parser-output .navbox .hlist td ol,.mw-parser-output .navbox .hlist td ul,.mw-parser-output .navbox td.hlist dl,.mw-parser-output .navbox td.hlist ol,.mw-parser-output .navbox td.hlist ul{padding:0.125em 0}.mw-parser-output .navbox .navbar{display:block;font-size:100%}.mw-parser-output .navbox-title .navbar{float:left;text-align:left;margin-right:0.5em}]]>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}]]>Wikimedia ErrorOur servers are currently under maintenance or experiencing a technical problem.Please try again in a few\u00a0minutes.See the error message at the bottom of this page for more\u00a0information.      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