[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/gpx5-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/gpx5-wikipedia\/","headline":"GPX5 – Wikipedia","name":"GPX5 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Glutathione peroxidase 5 (GPx-5), also known","datePublished":"2018-04-13","dateModified":"2018-04-13","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/gpx5-wikipedia\/","wordCount":3852,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensGlutathione peroxidase 5 (GPx-5), also known as epididymal secretory glutathione peroxidase is an enzyme that in humans is encoded by the GPX5 gene.[5][6]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4GPx-5 belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike mRNAs for other characterized glutathione peroxidases, this mRNA does not contain a selenocysteine (UGA) codon. Thus, the encoded protein is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and\/or preventing premature acrosome reaction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[5]References[edit]Further reading[edit]Talmud PJ, Drenos F, Shah S,  et\u00a0al. (2009). “Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip”. Am. J. Hum. Genet. 85 (5): 628\u201342. doi:10.1016\/j.ajhg.2009.10.014. PMC\u00a02775832. PMID\u00a019913121.Mungall AJ, Palmer SA, Sims SK,  et\u00a0al. (2003). “The DNA sequence and analysis of human chromosome 6”. Nature. 425 (6960): 805\u201311. Bibcode:2003Natur.425..805M. doi:10.1038\/nature02055. PMID\u00a014574404.Perry AC, Jones R, Niang LS,  et\u00a0al. (1992). “Genetic evidence for an androgen-regulated epididymal secretory glutathione peroxidase whose transcript does not contain a selenocysteine codon”. Biochem. J. 285 (3): 863\u201370. doi:10.1042\/bj2850863. PMC\u00a01132876. PMID\u00a01386734.Richard MJ, Guiraud P, Didier C,  et\u00a0al. (2001). “Human immunodeficiency virus type 1 Tat protein impairs selenoglutathione peroxidase expression and activity by a mechanism independent of cellular selenium uptake: consequences on cellular resistance to UV-A radiation”. Arch. Biochem. Biophys. 386 (2): 213\u201320. doi:10.1006\/abbi.2000.2197. PMID\u00a011368344.Opalenik SR, Ding Q, Mallery SR, Thompson JA (1998). “Glutathione depletion associated with the HIV-1 TAT protein mediates the extracellular appearance of acidic fibroblast growth factor”. Arch. Biochem. Biophys. 351 (1): 17\u201326. doi:10.1006\/abbi.1997.0566. PMID\u00a09501919.Hartley JL, Temple GF, Brasch MA (2000). “DNA cloning using in vitro site-specific recombination”. Genome Res. 10 (11): 1788\u201395. doi:10.1101\/gr.143000. PMC\u00a0310948. PMID\u00a011076863.Rejraji H, Vernet P, Drevet JR (2002). “GPX5 is present in the mouse caput and cauda epididymidis lumen at three different locations”. Mol. Reprod. Dev. 63 (1): 96\u2013103. doi:10.1002\/mrd.10136. PMID\u00a012211066. S2CID\u00a08103049.Ota T, Suzuki Y, Nishikawa T,  et\u00a0al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40\u20135. doi:10.1038\/ng1285. PMID\u00a014702039.Choi J, Liu RM, Kundu RK,  et\u00a0al. (2000). “Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 Tat-transgenic mice”. J. Biol. Chem. 275 (5): 3693\u20138. doi:10.1074\/jbc.275.5.3693. PMID\u00a010652368.Kimura K, Wakamatsu A, Suzuki Y,  et\u00a0al. (2006). “Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes”. Genome Res. 16 (1): 55\u201365. doi:10.1101\/gr.4039406. PMC\u00a01356129. PMID\u00a016344560.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2002). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Vernet P, Faure J, Dufaure JP, Drevet JR (1997). “Tissue and developmental distribution, dependence upon testicular factors and attachment to spermatozoa of GPX5, a murine epididymis-specific glutathione peroxidase”. Mol. Reprod. Dev. 47 (1): 87\u201398. doi:10.1002\/(SICI)1098-2795(199705)47:13.0.CO;2-X. PMID\u00a09110319. S2CID\u00a020995200.Price TO, Ercal N, Nakaoke R, Banks WA (2005). “HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells”. Brain Res. 1045 (1\u20132): 57\u201363. doi:10.1016\/j.brainres.2005.03.031. PMID\u00a015910762. S2CID\u00a07362454.Williams K, Frayne J, Hall L (1998). “Expression of extracellular glutathione peroxidase type 5 (GPX5) in the rat male reproductive tract”. Mol. Hum. Reprod. 4 (9): 841\u20138. doi:10.1093\/molehr\/4.9.841. PMID\u00a09783843.Bailey SD, Xie C, Do R,  et\u00a0al. (2010). “Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study”. Diabetes Care. 33 (10): 2250\u20133. doi:10.2337\/dc10-0452. PMC\u00a02945168. PMID\u00a020628086.Moyer AM, Sun Z, Batzler AJ,  et\u00a0al. (2010). “Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy”. Cancer Epidemiol. Biomarkers Prev. 19 (3): 811\u201321. doi:10.1158\/1055-9965.EPI-09-0871. PMC\u00a02837367. PMID\u00a020200426.       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/gpx5-wikipedia\/#breadcrumbitem","name":"GPX5 – Wikipedia"}}]}]