[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/grb10-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/grb10-wikipedia\/","headline":"GRB10 – Wikipedia","name":"GRB10 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Growth factor receptor-bound protein 10 also known as","datePublished":"2022-08-14","dateModified":"2022-08-14","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/9\/90\/PDB_1nrv_EBI.jpg\/180px-PDB_1nrv_EBI.jpg","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/9\/90\/PDB_1nrv_EBI.jpg\/180px-PDB_1nrv_EBI.jpg","height":"135","width":"180"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/grb10-wikipedia\/","wordCount":9304,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensGrowth factor receptor-bound protein 10 also known as insulin receptor-binding protein Grb-IR is a protein that in humans is encoded by the GRB10 gene.[5][6][7][8]Table of ContentsFunction[edit]Animal studies[edit]Interactions[edit]References[edit]Further reading[edit]External links[edit]Function[edit]The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors (e.g., IGF1R and IGF2R). Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have been identified.[5]Animal studies[edit]Mice whose paternally inherited Grb10 gene is inactivated are more aggressive while those whose maternally inherited allele is inactivated exhibit foetal overgrowth and are significantly bigger than wild-type litter-mates.[9]Interactions[edit]GRB10 has been shown to interact withReferences[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000106070 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020176 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ a b “Entrez Gene: GRB10 growth factor receptor-bound protein 10”.^ Jerome CA, Scherer SW, Tsui LC, Gietz RD, Triggs-Raine B (February 1997). “Assignment of growth factor receptor-bound protein 10 (GRB10) to human chromosome 7p11.2-p12”. Genomics. 40 (1): 215\u20136. doi:10.1006\/geno.1996.4535. PMID\u00a09070953.^ Dong LQ, Du H, Porter SG, Kolakowski LF, Lee AV, Mandarino LJ, Fan J, Yee D, Liu F, Mandarino J (November 1997). “Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma”. J. Biol. Chem. 272 (46): 29104\u201312. doi:10.1074\/jbc.272.46.29104. PMID\u00a09360986.^ Monk D, Arnaud P, Frost J, Hills FA, Stanier P, Feil R, Moore GE (August 2009). “Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression”. Hum. Mol. Genet. 18 (16): 3066\u201374. doi:10.1093\/hmg\/ddp248. PMID\u00a019487367.^ Garfield AS, Cowley M, Smith FM, Moorwood K, Stewart-Cox JE, Gilroy K, Baker S, Xia J, Dalley JW, Hurst LD, Wilkinson LS, Isles AR, Ward A (2011). “Distinct physiological and behavioural functions for parental alleles of imprinted Grb10”. Nature. 469 (7331): 534\u2013538. Bibcode:2011Natur.469..534G. doi:10.1038\/nature09651. PMC\u00a03031026. PMID\u00a021270893.*Lay summary in: Bhanoo SN (January 27, 2011). “Altering a Mouse Gene Turns Up Aggression, Study Says”. New York Times. ^ a b Bai RY, Jahn T, Schrem S, Munzert G, Weidner KM, Wang JY, Duyster J (August 1998). “The SH2-containing adapter protein GRB10 interacts with BCR-ABL”. Oncogene. 17 (8): 941\u20138. doi:10.1038\/sj.onc.1202024. PMID\u00a09747873.^ a b Frantz JD, Giorgetti-Peraldi S, Ottinger EA, Shoelson SE (January 1997). “Human GRB-IRbeta\/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains”. J Biol Chem. 272 (5): 2659\u201367. doi:10.1074\/jbc.272.5.2659. PMID\u00a09006901.^ Nantel A, Huber M, Thomas DY (December 1999). “Localization of endogenous Grb10 to the mitochondria and its interaction with the mitochondrial-associated Raf-1 pool”. J Biol Chem. 274 (50): 35719\u201324. doi:10.1074\/jbc.274.50.35719. PMID\u00a010585452.^ a b Nantel A, Mohammad-Ali K, Sherk J, Posner BI, Thomas DY (April 1998). “Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases”. J Biol Chem. 273 (17): 10475\u201384. doi:10.1074\/jbc.273.17.10475. PMID\u00a09553107.^ Jahn T, Seipel P, Urschel S, Peschel C, Duyster J (February 2002). “Role for the adaptor protein Grb10 in the activation of Akt”. Mol Cell Biol. 22 (4): 979\u201391. doi:10.1128\/MCB.22.4.979-991.2002. PMC\u00a0134632. PMID\u00a011809791.^ Langlais P, Dong LQ, Hu D, Liu F (June 2000). “Identification of Grb10 as a direct substrate for members of the Src tyrosine kinase family”. Oncogene. 19 (25): 2895\u2013903. doi:10.1038\/sj.onc.1203616. PMID\u00a010871840.^ Hansen H, Svensson U, Zhu J, Laviola L, Giorgino F, Wolf G, Smith RJ, Riedel H (April 1996). “Interaction between the Grb10 SH2 domain and the insulin receptor carboxyl terminus”. J Biol Chem. 271 (15): 8882\u20136. doi:10.1074\/jbc.271.15.8882. PMID\u00a08621530.^ Liu F, Roth RA (October 1995). “Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function”. Proc Natl Acad Sci U S A. 92 (22): 10287\u201391. Bibcode:1995PNAS…9210287L. doi:10.1073\/pnas.92.22.10287. PMC\u00a040781. PMID\u00a07479769.^ a b He W, Rose DW, Olefsky JM, Gustafson TA (March 1998). “Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains”. J Biol Chem. 273 (12): 6860\u20137. doi:10.1074\/jbc.273.12.6860. PMID\u00a09506989.^ Vecchione A, Marchese A, Henry P, Rotin D, Morrione A (May 2003). “The Grb10\/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor”. Mol Cell Biol. 23 (9): 3363\u201372. doi:10.1128\/MCB.23.9.3363-3372.2003. PMC\u00a0153198. PMID\u00a012697834.^ Dey BR, Frick K, Lopaczynski W, Nissley SP, Furlanetto RW (June 1996). “Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10”. Mol Endocrinol. 10 (6): 631\u201341. doi:10.1210\/mend.10.6.8776723. PMID\u00a08776723.^ Morrione A, Valentinis B, Li S, Ooi JY, Margolis B, Baserga R (July 1996). “Grb10: A new substrate of the insulin-like growth factor I receptor”. Cancer Res. 56 (14): 3165\u20137. PMID\u00a08764099.^ Pandey A, Duan H, Di Fiore PP, Dixit VM (September 1995). “The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10”. J Biol Chem. 270 (37): 21461\u20133. doi:10.1074\/jbc.270.37.21461. PMID\u00a07665556.Further reading[edit]Ram\u00edrez-Due\u00f1as ML, Medina C, Ocampo-Campos R, Rivera H (1992). “Severe Silver-Russell syndrome and translocation (17;20) (q25;q13)”. Clin. Genet. 41 (1): 51\u20133. doi:10.1111\/j.1399-0004.1992.tb03630.x. PMID\u00a01633648. S2CID\u00a028801507.Liu F, Roth RA (1995). “Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function”. Proc. Natl. Acad. Sci. U.S.A. 92 (22): 10287\u201391. Bibcode:1995PNAS…9210287L. doi:10.1073\/pnas.92.22.10287. PMC\u00a040781. PMID\u00a07479769.Pandey A, Duan H, Di Fiore PP, Dixit VM (1995). “The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10”. J. Biol. Chem. 270 (37): 21461\u20133. doi:10.1074\/jbc.270.37.21461. PMID\u00a07665556.Midro AT, Debek K, Sawicka A,  et\u00a0al. (1993). “Second observation of Silver-Russel syndrome in a carrier of a reciprocal translocation with one breakpoint at site 17q25”. Clin. Genet. 44 (1): 53\u20135. doi:10.1111\/j.1399-0004.1993.tb03845.x. PMID\u00a08403458. S2CID\u00a020766311.Hansen H, Svensson U, Zhu J,  et\u00a0al. (1996). “Interaction between the Grb10 SH2 domain and the insulin receptor carboxyl terminus”. J. Biol. Chem. 271 (15): 8882\u20136. doi:10.1074\/jbc.271.15.8882. PMID\u00a08621530.Morrione A, Valentinis B, Li S,  et\u00a0al. (1996). “Grb10: A new substrate of the insulin-like growth factor I receptor”. Cancer Res. 56 (14): 3165\u20137. PMID\u00a08764099.O’Neill TJ, Rose DW, Pillay TS,  et\u00a0al. (1996). “Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling”. J. Biol. Chem. 271 (37): 22506\u201313. doi:10.1074\/jbc.271.37.22506. PMID\u00a08798417.Stein E, Cerretti DP, Daniel TO (1996). “Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells”. J. Biol. Chem. 271 (38): 23588\u201393. doi:10.1074\/jbc.271.38.23588. PMID\u00a08798570.Frantz JD, Giorgetti-Peraldi S, Ottinger EA, Shoelson SE (1997). “Human GRB-IRbeta\/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains”. J. Biol. Chem. 272 (5): 2659\u201367. doi:10.1074\/jbc.272.5.2659. PMID\u00a09006901.Nagase T, Seki N, Ishikawa K,  et\u00a0al. (1997). “Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain”. DNA Res. 3 (5): 321\u20139, 341\u201354. doi:10.1093\/dnares\/3.5.321. PMID\u00a09039502.He W, Rose DW, Olefsky JM, Gustafson TA (1998). “Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains”. J. Biol. Chem. 273 (12): 6860\u20137. doi:10.1074\/jbc.273.12.6860. PMID\u00a09506989.Nantel A, Mohammad-Ali K, Sherk J,  et\u00a0al. (1998). “Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases”. J. Biol. Chem. 273 (17): 10475\u201384. doi:10.1074\/jbc.273.17.10475. PMID\u00a09553107.Moutoussamy S, Renaudie F, Lago F,  et\u00a0al. (1998). “Grb10 identified as a potential regulator of growth hormone (GH) signaling by cloning of GH receptor target proteins”. J. Biol. Chem. 273 (26): 15906\u201312. doi:10.1074\/jbc.273.26.15906. PMID\u00a09632636.Bai RY, Jahn T, Schrem S,  et\u00a0al. (1998). “The SH2-containing adapter protein GRB10 interacts with BCR-ABL”. Oncogene. 17 (8): 941\u20138. doi:10.1038\/sj.onc.1202024. PMID\u00a09747873.Mano H, Ohya K, Miyazato A,  et\u00a0al. (1998). “Grb10\/GrbIR as an in vivo substrate of Tec tyrosine kinase”. Genes Cells. 3 (7): 431\u201341. doi:10.1046\/j.1365-2443.1998.00201.x. PMID\u00a09753425. S2CID\u00a06391234.Washington University Genome Sequencing Cente (November 1998). “Toward a complete human genome sequence”. Genome Res. 8 (11): 1097\u2013108. doi:10.1101\/gr.8.11.1097. PMID\u00a09847074.Angrist M, Bolk S, Bentley K,  et\u00a0al. (1999). “Genomic structure of the gene for the SH2 and pleckstrin homology domain-containing protein GRB10 and evaluation of its role in Hirschsprung disease”. Oncogene. 17 (23): 3065\u201370. doi:10.1038\/sj.onc.1202226. PMID\u00a09881709.Wang J, Dai H, Yousaf N,  et\u00a0al. (1999). “Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis”. Mol. Cell. Biol. 19 (9): 6217\u201328. doi:10.1128\/MCB.19.9.6217. PMC\u00a084567. PMID\u00a010454568.External links[edit]PDB gallery1nrv: Crystal structure of the SH2 domain of Grb10This article incorporates text from the United States National Library of Medicine, which is in the public domain.  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/grb10-wikipedia\/#breadcrumbitem","name":"GRB10 – Wikipedia"}}]}]