[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/grb7-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/grb7-wikipedia\/","headline":"GRB7 – Wikipedia","name":"GRB7 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Growth factor receptor-bound protein 7, also known as","datePublished":"2019-12-02","dateModified":"2019-12-02","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/f\/f8\/PDB_1mw4_EBI.jpg\/180px-PDB_1mw4_EBI.jpg","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/f\/f8\/PDB_1mw4_EBI.jpg\/180px-PDB_1mw4_EBI.jpg","height":"135","width":"180"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/grb7-wikipedia\/","wordCount":9884,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensGrowth factor receptor-bound protein 7, also known as GRB7, is a protein that in humans is encoded by the GRB7 gene.[5][6]Table of ContentsFunction[edit]Clinical significance[edit]Interactions[edit]Model organisms[edit]References[edit]Further reading[edit]External links[edit]Function[edit]The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Alternative splicing results in multiple transcript variants encoding different isoforms, although the full-length natures of only two of the variants have been determined to date.[5]Clinical significance[edit]GRB7 is an SH2-domain adaptor protein that binds to receptor tyrosine kinases and provides the intra-cellular direct link to the Ras proto-oncogene.Human GRB7 is located on the long arm of chromosome 17, next to the ERBB2 (alias HER2\/neu) proto-oncogene.These two genes are commonly co-amplified (present in excess copies) in breast cancers.GRB7, thought to be involved in migration[citation needed], is well known to be over-expressed in testicular germ cell tumors, esophageal cancers, and gastric cancers.Interactions[edit]GRB7 has been shown to interact with:Model organisms[edit]Model organisms have been used in the study of GRB7 function. A conditional knockout mouse line called Grb7tm1b(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[12] Male and female animals underwent a standardized phenotypic screen[13] to determine the effects of deletion.[14][15][16][17] Additional screens performed:  – In-depth immunological phenotyping[18]Grb7 knockout mouse phenotypeCharacteristicPhenotypeAll data available at.[13][18]Peripheral blood leukocytes 6 WeeksNormalHaematology 6 WeeksNormalHomozygous viability at P14NormalHomozygous FertilityNormalBody weightNormalNeurological assessmentNormalGrip strengthNormalDysmorphologyNormalIndirect calorimetryNormalGlucose tolerance testNormalAuditory brainstem responseNormalDEXANormalEye morphologyNormalClinical chemistryNormalHaematology 16 WeeksNormalPeripheral blood leukocytes 16 WeeksNormalHeart weightNormalSalmonella infectionNormalCytotoxic T Cell FunctionNormalSpleen ImmunophenotypingNormalMesenteric Lymph Node ImmunophenotypingNormalBone Marrow ImmunophenotypingNormalEpidermal Immune CompositionNormalTrichuris ChallengeNormalReferences[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000141738 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019312 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ a b “Entrez Gene: GRB7 growth factor receptor-bound protein 7”.^ Tanaka S, Mori M, Akiyoshi T, Tanaka Y, Mafune K, Wands JR, Sugimachi K (Aug 1998). “A novel variant of human Grb7 is associated with invasive esophageal carcinoma”. The Journal of Clinical Investigation. 102 (4): 821\u20137. doi:10.1172\/JCI2921. PMC\u00a0508945. PMID\u00a09710451.^ Han DC, Shen TL, Miao H, Wang B, Guan JL (Nov 2002). “EphB1 associates with Grb7 and regulates cell migration”. The Journal of Biological Chemistry. 277 (47): 45655\u201361. doi:10.1074\/jbc.M203165200. PMID\u00a012223469.^ Kasus-Jacobi A, B\u00e9r\u00e9ziat V, Perdereau D, Girard J, Burnol AF (Apr 2000). “Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2”. Oncogene. 19 (16): 2052\u20139. doi:10.1038\/sj.onc.1203469. PMID\u00a010803466.^ Han DC, Guan JL (Aug 1999). “Association of focal adhesion kinase with Grb7 and its role in cell migration”. The Journal of Biological Chemistry. 274 (34): 24425\u201330. doi:10.1074\/jbc.274.34.24425. PMID\u00a010446223.^ Pandey A, Liu X, Dixon JE, Di Fiore PP, Dixit VM (May 1996). “Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7”. The Journal of Biological Chemistry. 271 (18): 10607\u201310. doi:10.1074\/jbc.271.18.10607. PMID\u00a08631863.^ Vayssi\u00e8re B, Zalcman G, Mah\u00e9 Y, Mirey G, Ligensa T, Weidner KM, Chardin P, Camonis J (Feb 2000). “Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family”. FEBS Letters. 467 (1): 91\u20136. doi:10.1016\/s0014-5793(99)01530-6. PMID\u00a010664463. S2CID\u00a04901644.^ Gerdin AK (2010). “The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice”. Acta Ophthalmologica. 88: 925\u20137. doi:10.1111\/j.1755-3768.2010.4142.x. S2CID\u00a085911512.^ a b “International Mouse Phenotyping Consortium”.^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). “A conditional knockout resource for the genome-wide study of mouse gene function”. Nature. 474 (7351): 337\u201342. doi:10.1038\/nature10163. PMC\u00a03572410. PMID\u00a021677750.^ Dolgin E (Jun 2011). “Mouse library set to be knockout”. Nature. 474 (7351): 262\u20133. doi:10.1038\/474262a. PMID\u00a021677718.^ Collins FS, Rossant J, Wurst W (Jan 2007). “A mouse for all reasons”. Cell. 128 (1): 9\u201313. doi:10.1016\/j.cell.2006.12.018. PMID\u00a017218247. S2CID\u00a018872015.^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). “Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes”. Cell. 154 (2): 452\u201364. doi:10.1016\/j.cell.2013.06.022. PMC\u00a03717207. PMID\u00a023870131.^ a b “Infection and Immunity Immunophenotyping (3i) Consortium”.Further reading[edit]Han DC, Shen TL, Guan JL (Oct 2001). “The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions”. Oncogene. 20 (44): 6315\u201321. doi:10.1038\/sj.onc.1204775. PMID\u00a011607834.Margolis B, Silvennoinen O, Comoglio F, Roonprapunt C, Skolnik E, Ullrich A, Schlessinger J (Oct 1992). “High-efficiency expression\/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains”. Proceedings of the National Academy of Sciences of the United States of America. 89 (19): 8894\u20138. Bibcode:1992PNAS…89.8894M. doi:10.1073\/pnas.89.19.8894. PMC\u00a050030. PMID\u00a01409582.Skotheim RI, Abeler VM, Nesland JM, Foss\u00e5 SD, Holm R, Wagner U, Fl\u00f8renes VA, Aass N, Kallioniemi OP, Lothe RA (2003). “Candidate genes for testicular cancer evaluated by in situ protein expression analyses on tissue microarrays”. Neoplasia. 5 (5): 397\u2013404. doi:10.1016\/s1476-5586(03)80042-8. PMC\u00a01502610. PMID\u00a014670177.Maruyama K, Sugano S (Jan 1994). “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1\u20132): 171\u20134. doi:10.1016\/0378-1119(94)90802-8. PMID\u00a08125298.Pandey A, Liu X, Dixon JE, Di Fiore PP, Dixit VM (May 1996). “Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7”. The Journal of Biological Chemistry. 271 (18): 10607\u201310. doi:10.1074\/jbc.271.18.10607. PMID\u00a08631863.Yokote K, Margolis B, Heldin CH, Claesson-Welsh L (Nov 1996). “Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors”. The Journal of Biological Chemistry. 271 (48): 30942\u20139. doi:10.1074\/jbc.271.48.30942. PMID\u00a08940081.Tanaka S, Mori M, Akiyoshi T, Tanaka Y, Mafune K, Wands JR, Sugimachi K (Jan 1997). “Coexpression of Grb7 with epidermal growth factor receptor or Her2\/erbB2 in human advanced esophageal carcinoma”. Cancer Research. 57 (1): 28\u201331. PMID\u00a08988034.Janes PW, Lackmann M, Church WB, Sanderson GM, Sutherland RL, Daly RJ (Mar 1997). “Structural determinants of the interaction between the erbB2 receptor and the Src homology 2 domain of Grb7”. The Journal of Biological Chemistry. 272 (13): 8490\u20137. doi:10.1074\/jbc.272.13.8490. PMID\u00a09079677.Kishi T, Sasaki H, Akiyama N, Ishizuka T, Sakamoto H, Aizawa S, Sugimura T, Terada M (Mar 1997). “Molecular cloning of human GRB-7 co-amplified with CAB1 and c-ERBB-2 in primary gastric cancer”. Biochemical and Biophysical Research Communications. 232 (1): 5\u20139. doi:10.1006\/bbrc.1997.6218. PMID\u00a09125150.Dong LQ, Du H, Porter SG, Kolakowski LF, Lee AV, Mandarino LJ, Fan J, Yee D, Liu F, Mandarino J (Nov 1997). “Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma”. The Journal of Biological Chemistry. 272 (46): 29104\u201312. doi:10.1074\/jbc.272.46.29104. PMID\u00a09360986.Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). “Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library”. Gene. 200 (1\u20132): 149\u201356. doi:10.1016\/S0378-1119(97)00411-3. PMID\u00a09373149.Fiddes RJ, Campbell DH, Janes PW, Sivertsen SP, Sasaki H, Wallasch C, Daly RJ (Mar 1998). “Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3”. The Journal of Biological Chemistry. 273 (13): 7717\u201324. doi:10.1074\/jbc.273.13.7717. PMID\u00a09516479.Tanaka S, Mori M, Akiyoshi T, Tanaka Y, Mafune K, Wands JR, Sugimachi K (Aug 1998). “A novel variant of human Grb7 is associated with invasive esophageal carcinoma”. The Journal of Clinical Investigation. 102 (4): 821\u20137. doi:10.1172\/JCI2921. PMC\u00a0508945. PMID\u00a09710451.Th\u00f6mmes K, Lennartsson J, Carlberg M, R\u00f6nnstrand L (Jul 1999). “Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit\/stem cell factor receptor”. The Biochemical Journal. 341 (1): 211\u20136. doi:10.1042\/0264-6021:3410211. PMC\u00a01220349. PMID\u00a010377264.Han DC, Guan JL (Aug 1999). “Association of focal adhesion kinase with Grb7 and its role in cell migration”. The Journal of Biological Chemistry. 274 (34): 24425\u201330. doi:10.1074\/jbc.274.34.24425. PMID\u00a010446223.Jones N, Master Z, Jones J, Bouchard D, Gunji Y, Sasaki H, Daly R, Alitalo K, Dumont DJ (Oct 1999). “Identification of Tek\/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration”. The Journal of Biological Chemistry. 274 (43): 30896\u2013905. doi:10.1074\/jbc.274.43.30896. PMID\u00a010521483.Vayssi\u00e8re B, Zalcman G, Mah\u00e9 Y, Mirey G, Ligensa T, Weidner KM, Chardin P, Camonis J (Feb 2000). “Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family”. FEBS Letters. 467 (1): 91\u20136. doi:10.1016\/S0014-5793(99)01530-6. PMID\u00a010664463. S2CID\u00a04901644.Kasus-Jacobi A, B\u00e9r\u00e9ziat V, Perdereau D, Girard J, Burnol AF (Apr 2000). “Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2”. Oncogene. 19 (16): 2052\u20139. doi:10.1038\/sj.onc.1203469. PMID\u00a010803466.Han DC, Shen TL, Guan JL (Sep 2000). “Role of Grb7 targeting to focal contacts and its phosphorylation by focal adhesion kinase in regulation of cell migration”. The Journal of Biological Chemistry. 275 (37): 28911\u20137. doi:10.1074\/jbc.M001997200. PMID\u00a010893408.Lee H, Volonte D, Galbiati F, Iyengar P, Lublin DM, Bregman DB, Wilson MT, Campos-Gonzalez R, Bouzahzah B, Pestell RG, Scherer PE, Lisanti MP (Nov 2000). “Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src\/Cav-1\/Grb7 signaling cassette”. Molecular Endocrinology. 14 (11): 1750\u201375. doi:10.1210\/mend.14.11.0553. PMID\u00a011075810.Skotheim RI, Abeler VM, Nesland JM, Foss\u00e5 SD, Holm R, Wagner U, Fl\u00f8renes VA, Aass N, Kallioniemi OP, Lothe RA (2003). “Candidate genes for testicular cancer evaluated by in situ protein expression analyses on tissue microarrays”. Neoplasia. 5 (5): 397\u2013404. doi:10.1016\/s1476-5586(03)80042-8. PMC\u00a01502610. PMID\u00a014670177.External links[edit]PDB gallery1mw4: Solution structure of the human Grb7-SH2 domain in complex with a 10 amino acid peptide pY11391wgr: Solution Structure of the RA Domain of Human Grb7 Protein  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/grb7-wikipedia\/#breadcrumbitem","name":"GRB7 – Wikipedia"}}]}]