[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/grin3a-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/grin3a-wikipedia\/","headline":"GRIN3A – Wikipedia","name":"GRIN3A – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Glutamate [NMDA] receptor subunit 3A is a protein","datePublished":"2021-02-03","dateModified":"2021-02-03","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/grin3a-wikipedia\/","about":["Wiki"],"wordCount":4435,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensGlutamate [NMDA] receptor subunit 3A is a protein that in humans is encoded by the GRIN3A gene.[5]Table of ContentsFunction[edit]See also[edit]References[edit]Further reading[edit]External links[edit]Function[edit]This gene encodes a subunit of the N-methyl-D-aspartate (NMDAR) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity.[5]See also[edit]References[edit]Further reading[edit]Schr\u00f6der HC, Perovic S, Kavsan V, Ushijima H, M\u00fcller WE (1998). “Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death”. Neurotoxicology. 19 (4\u20135): 683\u20138. PMID\u00a09745929.Eriksson M, Nilsson A, Samuelsson H, Samuelsson EB, Mo L, Akesson E, Benedikz E, Sundstr\u00f6m E (2007). “On the role of NR3A in human NMDA receptors”. Physiol. Behav. 92 (1\u20132): 54\u20139. doi:10.1016\/j.physbeh.2007.05.026. PMID\u00a017617428. S2CID\u00a021646700.Kornau HC, Schenker LT, Kennedy MB, Seeburg PH (1995). “Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95”. Science. 269 (5231): 1737\u201340. Bibcode:1995Sci…269.1737K. doi:10.1126\/science.7569905. PMID\u00a07569905.Magnuson DS, Knudsen BE, Geiger JD, Brownstone RM, Nath A (1995). “Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity”. Ann. Neurol. 37 (3): 373\u201380. doi:10.1002\/ana.410370314. PMID\u00a07695237. S2CID\u00a024405132.Lannuzel A, Lledo PM, Lamghitnia HO, Vincent JD, Tardieu M (1996). “HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons”. Eur. J. Neurosci. 7 (11): 2285\u201393. doi:10.1111\/j.1460-9568.1995.tb00649.x. PMID\u00a08563977. S2CID\u00a027201873.Corasaniti MT, Melino G, Navarra M, Garaci E, Finazzi-Agr\u00f2 A, Nistic\u00f2 G (1996). “Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase”. Neurodegeneration. 4 (3): 315\u201321. doi:10.1016\/1055-8330(95)90021-7. PMID\u00a08581564.Pittaluga A, Pattarini R, Severi P, Raiteri M (1996). “Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120”. AIDS. 10 (5): 463\u20138. doi:10.1097\/00002030-199605000-00003. PMID\u00a08724036. S2CID\u00a01669986.Wu P, Price P, Du B, Hatch WC, Terwilliger EF (1996). “Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons”. NeuroReport. 7 (5): 1045\u20139. doi:10.1097\/00001756-199604100-00018. PMID\u00a08804048. S2CID\u00a021018147.Bennett BA, Rusyniak DE, Hollingsworth CK (1996). “HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures”. Brain Res. 705 (1\u20132): 168\u201376. doi:10.1016\/0006-8993(95)01166-8. PMID\u00a08821747. S2CID\u00a032822686.Toggas SM, Masliah E, Mucke L (1996). “Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine”. Brain Res. 706 (2): 303\u20137. doi:10.1016\/0006-8993(95)01197-8. PMID\u00a08822372. S2CID\u00a044260060.Dreyer EB, Lipton SA (1996). “The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid”. Eur. J. Neurosci. 7 (12): 2502\u20137. doi:10.1111\/j.1460-9568.1995.tb01048.x. PMID\u00a08845955. S2CID\u00a07370984.Raber J, Toggas SM, Lee S, Bloom FE, Epstein CJ, Mucke L (1997). “Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase”. Virology. 226 (2): 362\u201373. doi:10.1006\/viro.1996.0664. PMID\u00a08955056.Das S, Sasaki YF, Rothe T, Premkumar LS, Takasu M, Crandall JE, Dikkes P, Conner DA, Rayudu PV, Cheung W, Chen HS, Lipton SA, Nakanishi N (1998). “Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A”. Nature. 393 (6683): 377\u201381. Bibcode:1998Natur.393..377D. doi:10.1038\/30748. PMID\u00a09620802. S2CID\u00a04391270.New DR, Maggirwar SB, Epstein LG, Dewhurst S, Gelbard HA (1998). “HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism”. J. Biol. Chem. 273 (28): 17852\u20138. doi:10.1074\/jbc.273.28.17852. PMID\u00a09651389.Wang P, Barks JD, Silverstein FS (1999). “Tat, a human immunodeficiency virus-1-derived protein, augments excitotoxic hippocampal injury in neonatal rats”. Neuroscience. 88 (2): 585\u201397. doi:10.1016\/S0306-4522(98)00242-5. PMID\u00a010197777. S2CID\u00a028927942.Howard SA, Nakayama AY, Brooke SM, Sapolsky RM (1999). “Glucocorticoid modulation of gp120-induced effects on calcium-dependent degenerative events in primary hippocampal and cortical cultures”. Exp. Neurol. 158 (1): 164\u201370. doi:10.1006\/exnr.1999.7080. PMID\u00a010448428. S2CID\u00a07598117.Xin KQ, Hamajima K, Hattori S, Cao XR, Kawamoto S, Okuda K (1999). “Evidence of HIV type 1 glycoprotein 120 binding to recombinant N-methyl-D-aspartate receptor subunits expressed in a baculovirus system”. AIDS Res. Hum. Retroviruses. 15 (16): 1461\u20137. doi:10.1089\/088922299309973. PMID\u00a010555109.Perez-Otano I, Schulteis CT, Contractor A, Lipton SA, Trimmer JS, Sucher NJ, Heinemann SF (2001). “Assembly with the NR1 subunit is required for surface expression of NR3A-containing NMDA receptors”. J. Neurosci. 21 (4): 1228\u201337. doi:10.1523\/JNEUROSCI.21-04-01228.2001. PMC\u00a06762235. PMID\u00a011160393.Haughey NJ, Nath A, Mattson MP, Slevin JT, Geiger JD (2001). “HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity”. J. Neurochem. 78 (3): 457\u201367. doi:10.1046\/j.1471-4159.2001.00396.x. PMID\u00a011483648. S2CID\u00a025641791.External links[edit]  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/grin3a-wikipedia\/#breadcrumbitem","name":"GRIN3A – Wikipedia"}}]}]