[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/hes5-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/hes5-wikipedia\/","headline":"HES5 – Wikipedia","name":"HES5 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Transcription factor HES-5 is a protein","datePublished":"2019-03-10","dateModified":"2019-03-10","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/hes5-wikipedia\/","about":["Wiki"],"wordCount":3812,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensTranscription factor HES-5 is a protein that in humans is encoded by the HES5 gene.[5][6]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4HES5 regulates the development of the early brain by maintaining stem cell neural progenitors in the ventricular zone.[7][8] HES5 expression significantly higher in squamous cervical carcinoma than in CIN as well as higher in CIN than normal cervical epithelia.[9] Human HES5 gene binds to Notch receptor and expression of HES5 decreases during cartilage differentiation.[10]References[edit]^ a b c ENSG00000197921 GRCh38: Ensembl release 89: ENSG00000273529, ENSG00000197921 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048001 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Takebayashi K, Akazawa C, Nakanishi S, Kageyama R (January 1995). “Structure and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-5. Identification of the neural precursor cell-specific promoter element”. The Journal of Biological Chemistry. 270 (3): 1342\u20131349. doi:10.1074\/jbc.270.3.1342. PMID\u00a07836401.^ “Entrez Gene: HES5 hairy and enhancer of split 5 (Drosophila)”.^ Ohtsuka T, Sakamoto M, Guillemot F, Kageyama R (August 2001). “Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain”. The Journal of Biological Chemistry. 276 (32): 30467\u201330474. doi:10.1074\/jbc.M102420200. PMID\u00a011399758.^ Hatakeyama J, Bessho Y, Katoh K, Ookawara S, Fujioka M, Guillemot F, Kageyama R (November 2004). “Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation”. Development. 131 (22): 5539\u20135550. doi:10.1242\/dev.01436. PMID\u00a015496443.^ Liu J, Ye F, Chen H, L\u00fc W, Zhou C, Xie X (2007). “Expression of differentiation associated protein Hes1 and Hes5 in cervical squamous carcinoma and its precursors”. International Journal of Gynecological Cancer. 17 (6): 1293\u20131299. doi:10.1111\/j.1525-1438.2007.00930.x. PMID\u00a017388915. S2CID\u00a025609083.^ Karlsson C, Jonsson M, Asp J, Brantsing C, Kageyama R, Lindahl A (March 2007). “Notch and HES5 are regulated during human cartilage differentiation”. Cell and Tissue Research. 327 (3): 539\u2013551. doi:10.1007\/s00441-006-0307-0. PMID\u00a017093926. S2CID\u00a033749726.Further reading[edit]Gazit R, Krizhanovsky V, Ben-Arie N (February 2004). “Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway”. Development. 131 (4): 903\u2013913. doi:10.1242\/dev.00982. PMID\u00a014757642.Nakatani T, Mizuhara E, Minaki Y, Sakamoto Y, Ono Y (April 2004). “Helt, a novel basic-helix-loop-helix transcriptional repressor expressed in the developing central nervous system”. The Journal of Biological Chemistry. 279 (16): 16356\u201316367. doi:10.1074\/jbc.M311740200. PMID\u00a014764602.Kamakura S, Oishi K, Yoshimatsu T, Nakafuku M, Masuyama N, Gotoh Y (June 2004). “Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling”. Nature Cell Biology. 6 (6): 547\u2013554. doi:10.1038\/ncb1138. PMID\u00a015156153. S2CID\u00a036887899.Katoh M, Katoh M (August 2004). “Identification and characterization of human HES2, HES3, and HES5 genes in silico”. International Journal of Oncology. 25 (2): 529\u2013534. doi:10.3892\/ijo.25.2.529. PMID\u00a015254753.Ohtsuka T, Imayoshi I, Shimojo H, Nishi E, Kageyama R, McConnell SK (January 2006). “Visualization of embryonic neural stem cells using Hes promoters in transgenic mice”. Molecular and Cellular Neurosciences. 31 (1): 109\u2013122. doi:10.1016\/j.mcn.2005.09.006. PMID\u00a016214363. S2CID\u00a035470002.Ong CT, Cheng HT, Chang LW, Ohtsuka T, Kageyama R, Stormo GD, Kopan R (February 2006). “Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability”. The Journal of Biological Chemistry. 281 (8): 5106\u20135119. doi:10.1074\/jbc.M506108200. PMID\u00a016365048.Karlsson C, Brantsing C, Svensson T, Brisby H, Asp J, Tallheden T, Lindahl A (February 2007). “Differentiation of human mesenchymal stem cells and articular chondrocytes: analysis of chondrogenic potential and expression pattern of differentiation-related transcription factors”. Journal of Orthopaedic Research. 25 (2): 152\u2013163. doi:10.1002\/jor.20287. PMID\u00a017072841.Karlsson C, Jonsson M, Asp J, Brantsing C, Kageyama R, Lindahl A (March 2007). “Notch and HES5 are regulated during human cartilage differentiation”. Cell and Tissue Research. 327 (3): 539\u2013551. doi:10.1007\/s00441-006-0307-0. PMID\u00a017093926. S2CID\u00a033749726.External links[edit]This article incorporates text from the United States National Library of Medicine, which is in the public domain.       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