[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/hoxb2-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/hoxb2-wikipedia\/","headline":"HOXB2 – Wikipedia","name":"HOXB2 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in humans Homeobox protein Hox-B2 is a protein that in humans is encoded","datePublished":"2022-09-10","dateModified":"2022-09-10","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/hoxb2-wikipedia\/","wordCount":4113,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in humansHomeobox protein Hox-B2 is a protein that in humans is encoded by the HOXB2 gene.[5][6][7]Table of ContentsFunction[edit]See also[edit]References[edit]Further reading[edit]External links[edit]Function[edit]This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer.[7]See also[edit]References[edit]Further reading[edit]Lavelle D, Ducksworth J, Eves E, Gomes G, Keller M, Heller P, DeSimone J (Aug 1991). “A homeodomain protein binds to gamma-globin gene regulatory sequences”. Proceedings of the National Academy of Sciences of the United States of America. 88 (16): 7318\u201322. Bibcode:1991PNAS…88.7318L. doi:10.1073\/pnas.88.16.7318. PMC\u00a052286. PMID\u00a01871139.Giampaolo A, Acampora D, Zappavigna V, Pannese M, D’Esposito M, Car\u00e8 A, Faiella A, Stornaiuolo A, Russo G, Simeone A (Jun 1989). “Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system”. Differentiation; Research in Biological Diversity. 40 (3): 191\u20137. doi:10.1111\/j.1432-0436.1989.tb00598.x. PMID\u00a02570724.Acampora D, D’Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (Dec 1989). “The human HOX gene family”. Nucleic Acids Research. 17 (24): 10385\u2013402. doi:10.1093\/nar\/17.24.10385. PMC\u00a0335308. PMID\u00a02574852.Boncinelli E, Acampora D, Pannese M, D’Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A (1990). “Organization of human class I homeobox genes”. Genome. 31 (2): 745\u201356. doi:10.1139\/g89-133. PMID\u00a02576652.Kongsuwan K, Webb E, Housiaux P, Adams JM (Jul 1988). “Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages”. The EMBO Journal. 7 (7): 2131\u20138. doi:10.1002\/j.1460-2075.1988.tb03052.x. PMC\u00a0454515. PMID\u00a02901346.Vieille-Grosjean I, Huber P (Mar 1995). “Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells”. The Journal of Biological Chemistry. 270 (9): 4544\u201350. doi:10.1074\/jbc.270.9.4544. PMID\u00a07876223.Guazzi S, Lonigro R, Pintonello L, Boncinelli E, Di Lauro R, Mavilio F (Jul 1994). “The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins”. The EMBO Journal. 13 (14): 3339\u201347. doi:10.1002\/j.1460-2075.1994.tb06636.x. PMC\u00a0395231. PMID\u00a07913891.Guazzi S, Pintonello ML, Vigan\u00f2 A, Boncinelli E (May 1998). “Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells”. The Journal of Biological Chemistry. 273 (18): 11092\u20139. doi:10.1074\/jbc.273.18.11092. PMID\u00a09556594.Davenne M, Maconochie MK, Neun R, Pattyn A, Chambon P, Krumlauf R, Rijli FM (Apr 1999). “Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain”. Neuron. 22 (4): 677\u201391. doi:10.1016\/S0896-6273(00)80728-X. PMID\u00a010230789.Case SS, Huber P, Lloyd JA (Nov 1999). “The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation”. DNA and Cell Biology. 18 (11): 805\u201317. doi:10.1089\/104454999314809. PMID\u00a010595394.Golpon HA, Geraci MW, Moore MD, Miller HL, Miller GJ, Tuder RM, Voelkel NF (Mar 2001). “HOX genes in human lung: altered expression in primary pulmonary hypertension and emphysema”. The American Journal of Pathology. 158 (3): 955\u201366. doi:10.1016\/S0002-9440(10)64042-4. PMC\u00a01850338. PMID\u00a011238043.Shen WF, Krishnan K, Lawrence HJ, Largman C (Nov 2001). “The HOX homeodomain proteins block CBP histone acetyltransferase activity”. Molecular and Cellular Biology. 21 (21): 7509\u201322. doi:10.1128\/MCB.21.21.7509-7522.2001. PMC\u00a099922. PMID\u00a011585930.Liu X, Zhang X (Feb 2002). “Effect of anti-sense oligodeoxynucleotides homeobox B2 on the proliferation and expression of primary human umbilical vein endothelial cells”. Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi. 5 (1): 12\u20135. PMID\u00a011835749.Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N (Feb 2002). “Complete mutation analysis panel of the 39 human HOX genes”. Teratology. 65 (2): 50\u201362. doi:10.1002\/tera.10009. PMID\u00a011857506.Ivins S, Pemberton K, Guidez F, Howell L, Krumlauf R, Zelent A (Jun 2003). “Regulation of Hoxb2 by APL-associated PLZF protein”. Oncogene. 22 (24): 3685\u201397. doi:10.1038\/sj.onc.1206328. PMID\u00a012802276.Segara D, Biankin AV, Kench JG, Langusch CC, Dawson AC, Skalicky DA, Gotley DC, Coleman MJ, Sutherland RL, Henshall SM (May 2005). “Expression of HOXB2, a retinoic acid signaling target in pancreatic cancer and pancreatic intraepithelial neoplasia”. Clinical Cancer Research. 11 (9): 3587\u201396. doi:10.1158\/1078-0432.CCR-04-1813. PMID\u00a015867264.External links[edit]This article incorporates text from the United States National Library of Medicine, which is in the public domain.  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/hoxb2-wikipedia\/#breadcrumbitem","name":"HOXB2 – Wikipedia"}}]}]