[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/hoxb3-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/hoxb3-wikipedia\/","headline":"HOXB3 – Wikipedia","name":"HOXB3 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Homeobox protein Hox-B3 is a protein","datePublished":"2016-06-06","dateModified":"2016-06-06","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/hoxb3-wikipedia\/","wordCount":4157,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensHomeobox protein Hox-B3 is a protein that in humans is encoded by the HOXB3 gene.[5][6][7]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML).[7]Table of ContentsSee also[edit]References[edit]Further reading[edit]External links[edit]See also[edit]References[edit]Further reading[edit]Giampaolo A, Acampora D, Zappavigna V,  et\u00a0al. (1989). “Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system”. Differentiation. 40 (3): 191\u20137. doi:10.1111\/j.1432-0436.1989.tb00598.x. PMID\u00a02570724.Acampora D, D’Esposito M, Faiella A,  et\u00a0al. (1990). “The human HOX gene family”. Nucleic Acids Res. 17 (24): 10385\u2013402. doi:10.1093\/nar\/17.24.10385. PMC\u00a0335308. PMID\u00a02574852.Boncinelli E, Acampora D, Pannese M,  et\u00a0al. (1990). “Organization of human class I homeobox genes”. Genome. 31 (2): 745\u201356. doi:10.1139\/g89-133. PMID\u00a02576652.Guazzi S, Lonigro R, Pintonello L,  et\u00a0al. (1994). “The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins”. EMBO J. 13 (14): 3339\u201347. doi:10.1002\/j.1460-2075.1994.tb06636.x. PMC\u00a0395231. PMID\u00a07913891.Apiou F, Flagiello D, Cillo C,  et\u00a0al. (1996). “Fine mapping of human HOX gene clusters”. Cytogenet. Cell Genet. 73 (1\u20132): 114\u20135. doi:10.1159\/000134320. PMID\u00a08646877.Bingle CD, Gowan S (1996). “Oct-1 interacts with conserved motifs in the human thyroid transcription factor 1 gene minimal promoter”. Biochem. J. 319 ( Pt 3) (Pt 3): 669\u201374. doi:10.1042\/bj3190669. PMC\u00a01217841. PMID\u00a08920965.Sauvageau G, Thorsteinsdottir U, Hough MR,  et\u00a0al. (1997). “Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation”. Immunity. 6 (1): 13\u201322. doi:10.1016\/S1074-7613(00)80238-1. PMID\u00a09052833.Guazzi S, Pintonello ML, Vigan\u00f2 A, Boncinelli E (1998). “Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells”. J. Biol. Chem. 273 (18): 11092\u20139. doi:10.1074\/jbc.273.18.11092. PMID\u00a09556594.Vigan\u00f2 MA, Di Rocco G, Zappavigna V, Mavilio F (1998). “Definition of the Transcriptional Activation Domains of Three Human HOX Proteins Depends on the DNA-Binding Context”. Mol. Cell. Biol. 18 (11): 6201\u201312. doi:10.1128\/MCB.18.11.6201. PMC\u00a0109207. PMID\u00a09774637.Kosaki K, Kosaki R, Suzuki T,  et\u00a0al. (2002). “Complete mutation analysis panel of the 39 human HOX genes”. Teratology. 65 (2): 50\u201362. doi:10.1002\/tera.10009. PMID\u00a011857506.Nakamura N, Yoshimi T, Miura T (2002). “Increased gene expression of lung marker proteins in the homeobox B3-overexpressed fetal lung cell line M3E3\/C3”. Cell Growth Differ. 13 (4): 195\u2013203. PMID\u00a011971819.Ota T, Suzuki Y, Nishikawa T,  et\u00a0al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40\u20135. doi:10.1038\/ng1285. PMID\u00a014702039.Pineault N, Abramovich C, Ohta H, Humphries RK (2004). “Differential and Common Leukemogenic Potentials of Multiple NUP98-Hox Fusion Proteins Alone or with Meis1”. Mol. Cell. Biol. 24 (5): 1907\u201317. doi:10.1128\/MCB.24.5.1907-1917.2004. PMC\u00a0350554. PMID\u00a014966272.Roche J, Zeng C, Bar\u00f3n A,  et\u00a0al. (2004). “Hox expression in AML identifies a distinct subset of patients with intermediate cytogenetics”. Leukemia. 18 (6): 1059\u201363. doi:10.1038\/sj.leu.2403366. PMID\u00a015085154. S2CID\u00a09417756.Brandenberger R, Wei H, Zhang S,  et\u00a0al. (2005). “Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation”. Nat. Biotechnol. 22 (6): 707\u201316. doi:10.1038\/nbt971. PMID\u00a015146197. S2CID\u00a027764390.Speleman F, Cauwelier B, Dastugue N,  et\u00a0al. (2005). “A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias”. Leukemia. 19 (3): 358\u201366. doi:10.1038\/sj.leu.2403657. PMID\u00a015674412.Kimura K, Wakamatsu A, Suzuki Y,  et\u00a0al. (2006). “Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes”. Genome Res. 16 (1): 55\u201365. doi:10.1101\/gr.4039406. PMC\u00a01356129. PMID\u00a016344560.External links[edit]This article incorporates text from the United States National Library of Medicine, which is in the public domain.       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/hoxb3-wikipedia\/#breadcrumbitem","name":"HOXB3 – Wikipedia"}}]}]