[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/hspa4-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/hspa4-wikipedia\/","headline":"HSPA4 – Wikipedia","name":"HSPA4 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Heat shock 70 kDa protein 4 is a","datePublished":"2014-06-05","dateModified":"2014-06-05","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/hspa4-wikipedia\/","about":["Wiki"],"wordCount":7105,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensHeat shock 70 kDa protein 4 is a protein that in humans is encoded by the HSPA4 gene.[5][6]The protein encoded by this gene was originally suggested to be a member of the heat shock protein 70 family.[5]  However it is now known that human HSPA4 is an equivalent to mouse the Apg-2 protein and is a member of the Hsp110 family.[7]Table of ContentsInteractions[edit]References[edit]Further reading[edit]External links[edit]Interactions[edit]HSPA4 has been shown to interact with:References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000170606 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020361 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ a b Fathallah DM, Cherif D, Dellagi K, Arnaout MA (Jul 1993). “Molecular cloning of a novel human hsp70 from a B cell line and its assignment to chromosome 5”. Journal of Immunology. 151 (2): 810\u20133. PMID\u00a08335910.^ “Entrez Gene: HSPA4 heat shock 70kDa protein 4”.^ Kaneko Y, Kimura T, Kishishita M, Noda Y, Fujita J (Apr 1997). “Cloning of apg-2 encoding a novel member of heat shock protein 110 family”. Gene. 189 (1): 19\u201324. doi:10.1016\/S0378-1119(96)00807-4. PMID\u00a09161406.^ Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES (Aug 2000). “Negative regulation of the Apaf-1 apoptosome by Hsp70”. Nature Cell Biology. 2 (8): 476\u201383. doi:10.1038\/35019510. PMID\u00a010934467. S2CID\u00a020374981.^ a b c Oh WK, Song J (Aug 2003). “Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation”. Molecules and Cells. 16 (1): 84\u201391. PMID\u00a014503850.^ a b Johnson CA, White DA, Lavender JS, O’Neill LP, Turner BM (Mar 2002). “Human class I histone deacetylase complexes show enhanced catalytic activity in the presence of ATP and co-immunoprecipitate with the ATP-dependent chaperone protein Hsp70”. The Journal of Biological Chemistry. 277 (11): 9590\u20137. doi:10.1074\/jbc.M107942200. PMID\u00a011777905.^ Nair SC, Toran EJ, Rimerman RA, Hjermstad S, Smithgall TE, Smith DF (Dec 1996). “A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor”. Cell Stress & Chaperones. 1 (4): 237\u201350. PMC\u00a0376461. PMID\u00a09222609.^ Abravaya K, Myers MP, Murphy SP, Morimoto RI (Jul 1992). “The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression”. Genes & Development. 6 (7): 1153\u201364. doi:10.1101\/gad.6.7.1153. PMID\u00a01628823.^ Anwar A, Siegel D, Kepa JK, Ross D (Apr 2002). “Interaction of the molecular chaperone Hsp70 with human NAD(P)H:quinone oxidoreductase 1”. The Journal of Biological Chemistry. 277 (16): 14060\u20137. doi:10.1074\/jbc.M111576200. PMID\u00a011821413.^ Ballinger CA, Connell P, Wu Y, Hu Z, Thompson LJ, Yin LY, Patterson C (Jun 1999). “Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions”. Molecular and Cellular Biology. 19 (6): 4535\u201345. doi:10.1128\/mcb.19.6.4535. PMC\u00a0104411. PMID\u00a010330192.Further reading[edit]Abravaya K, Myers MP, Murphy SP, Morimoto RI (Jul 1992). “The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression”. Genes & Development. 6 (7): 1153\u201364. doi:10.1101\/gad.6.7.1153. PMID\u00a01628823.Liao J, Lowthert LA, Ghori N, Omary MB (Jan 1995). “The 70-kDa heat shock proteins associate with glandular intermediate filaments in an ATP-dependent manner”. The Journal of Biological Chemistry. 270 (2): 915\u201322. doi:10.1074\/jbc.270.2.915. PMID\u00a07529764.Furlini G, Vignoli M, Re MC, Gibellini D, Ramazzotti E, Zauli G, La Placa M (Jan 1994). “Human immunodeficiency virus type 1 interaction with the membrane of CD4+ cells induces the synthesis and nuclear translocation of 70K heat shock protein”. The Journal of General Virology. 75 (1): 193\u20139. doi:10.1099\/0022-1317-75-1-193. PMID\u00a07906708.Bonaldo MF, Lennon G, Soares MB (Sep 1996). “Normalization and subtraction: two approaches to facilitate gene discovery”. Genome Research. 6 (9): 791\u2013806. doi:10.1101\/gr.6.9.791. PMID\u00a08889548.Schulte AM, Fischer S, Sachse GE, H\u00e4fner S, Stelck S, Gassen HG (Mar 1997). “Identification and characterization of a novel hsc70-like gene in the human lung tumor cell line HS24”. DNA and Cell Biology. 16 (3): 257\u201368. doi:10.1089\/dna.1997.16.257. PMID\u00a09115634.Kaneko Y, Kimura T, Kishishita M, Noda Y, Fujita J (Apr 1997). “Cloning of apg-2 encoding a novel member of heat shock protein 110 family”. Gene. 189 (1): 19\u201324. doi:10.1016\/S0378-1119(96)00807-4. PMID\u00a09161406.Bruner KL, Derfoul A, Robertson NM, Guerriero G, Fernandes-Alnemri T, Alnemri ES, Litwack G (1998). “The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52”. Receptors & Signal Transduction. 7 (2): 85\u201398. PMID\u00a09392437.Satyal SH, Chen D, Fox SG, Kramer JM, Morimoto RI (Jul 1998). “Negative regulation of the heat shock transcriptional response by HSBP1”. Genes & Development. 12 (13): 1962\u201374. doi:10.1101\/gad.12.13.1962. PMC\u00a0316975. PMID\u00a09649501.Naylor DJ, Stines AP, Hoogenraad NJ, H\u00f8j PB (Aug 1998). “Evidence for the existence of distinct mammalian cytosolic, microsomal, and two mitochondrial GrpE-like proteins, the Co-chaperones of specific Hsp70 members”. The Journal of Biological Chemistry. 273 (33): 21169\u201377. doi:10.1074\/jbc.273.33.21169. PMID\u00a09694873.Melville MW, Tan SL, Wambach M, Song J, Morimoto RI, Katze MG (Feb 1999). “The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity”. The Journal of Biological Chemistry. 274 (6): 3797\u2013803. doi:10.1074\/jbc.274.6.3797. PMID\u00a09920933.Ballinger CA, Connell P, Wu Y, Hu Z, Thompson LJ, Yin LY, Patterson C (Jun 1999). “Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions”. Molecular and Cellular Biology. 19 (6): 4535\u201345. doi:10.1128\/mcb.19.6.4535. PMC\u00a0104411. PMID\u00a010330192.Liu H, Vuyyuru VB, Pham CD, Yang Y, Singh B (Jun 1999). “Evidence of an interaction between Mos and Hsp70: a role of the Mos residue serine 3 in mediating Hsp70 association”. Oncogene. 18 (23): 3461\u201370. doi:10.1038\/sj.onc.1202699. PMID\u00a010376524.Nonoguchi K, Itoh K, Xue JH, Tokuchi H, Nishiyama H, Kaneko Y, Tatsumi K, Okuno H, Tomiwa K, Fujita J (Sep 1999). “Cloning of human cDNAs for Apg-1 and Apg-2, members of the Hsp110 family, and chromosomal assignment of their genes”. Gene. 237 (1): 21\u20138. doi:10.1016\/S0378-1119(99)00325-X. PMID\u00a010524232.O’Keeffe B, Fong Y, Chen D, Zhou S, Zhou Q (Jan 2000). “Requirement for a kinase-specific chaperone pathway in the production of a Cdk9\/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription”. The Journal of Biological Chemistry. 275 (1): 279\u201387. doi:10.1074\/jbc.275.1.279. PMID\u00a010617616.Agostini I, Popov S, Li J, Dubrovsky L, Hao T, Bukrinsky M (Sep 2000). “Heat-shock protein 70 can replace viral protein R of HIV-1 during nuclear import of the viral preintegration complex”. Experimental Cell Research. 259 (2): 398\u2013403. doi:10.1006\/excr.2000.4992. PMID\u00a010964507.Kim M, Jiang LH, Wilson HL, North RA, Surprenant A (Nov 2001). “Proteomic and functional evidence for a P2X7 receptor signalling complex”. The EMBO Journal. 20 (22): 6347\u201358. doi:10.1093\/emboj\/20.22.6347. PMC\u00a0125721. PMID\u00a011707406.Johnson CA, White DA, Lavender JS, O’Neill LP, Turner BM (Mar 2002). “Human class I histone deacetylase complexes show enhanced catalytic activity in the presence of ATP and co-immunoprecipitate with the ATP-dependent chaperone protein Hsp70”. The Journal of Biological Chemistry. 277 (11): 9590\u20137. doi:10.1074\/jbc.M107942200. PMID\u00a011777905.Gurer C, Cimarelli A, Luban J (May 2002). “Specific incorporation of heat shock protein 70 family members into primate lentiviral virions”. Journal of Virology. 76 (9): 4666\u201370. doi:10.1128\/JVI.76.9.4666-4670.2002. PMC\u00a0155079. PMID\u00a011932435.Freeman BC, Yamamoto KR (Jun 2002). “Disassembly of transcriptional regulatory complexes by molecular chaperones”. Science. 296 (5576): 2232\u20135. doi:10.1126\/science.1073051. PMID\u00a012077419. S2CID\u00a08844179.External links[edit]  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/hspa4-wikipedia\/#breadcrumbitem","name":"HSPA4 – Wikipedia"}}]}]