[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/hspb2-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/hspb2-wikipedia\/","headline":"HSPB2 – Wikipedia","name":"HSPB2 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Heat shock protein beta-2 is a protein that","datePublished":"2019-01-23","dateModified":"2019-01-23","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/hspb2-wikipedia\/","wordCount":5930,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensHeat shock protein beta-2 is a protein that in humans is encoded by the HSPB2 gene.[5][6][7]Interactions[edit]HSPB2 has been shown to interact with:References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000170276 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038086 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Iwaki A, Nagano T, Nakagawa M, Iwaki T, Fukumaki Y (February 1998). “Identification and characterization of the gene encoding a new member of the alpha-crystallin\/small hsp family, closely linked to the alphaB-crystallin gene in a head-to-head manner”. Genomics. 45 (2): 386\u201394. doi:10.1006\/geno.1997.4956. PMID\u00a09344664.^ a b Suzuki A, Sugiyama Y, Hayashi Y, Nyu-i N, Yoshida M, Nonaka I, Ishiura S, Arahata K, Ohno S (April 1998). “MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase”. J Cell Biol. 140 (5): 1113\u201324. doi:10.1083\/jcb.140.5.1113. PMC\u00a02132705. PMID\u00a09490724.^ “Entrez Gene: HSPB2 heat shock 27kDa protein 2”.^ a b Sugiyama Y, Suzuki A, Kishikawa M, Akutsu R, Hirose T, Waye MM, Tsui SK, Yoshida S, Ohno S (January 2000). “Muscle develops a specific form of small heat shock protein complex composed of MKBP\/HSPB2 and HSPB3 during myogenic differentiation”. J. Biol. Chem. 275 (2): 1095\u2013104. doi:10.1074\/jbc.275.2.1095. PMID\u00a010625651.^ Sun X, Fontaine JM, Rest JS, Shelden EA, Welsh MJ, Benndorf R (January 2004). “Interaction of human HSP22 (HSPB8) with other small heat shock proteins”. J. Biol. Chem. 279 (4): 2394\u2013402. doi:10.1074\/jbc.M311324200. PMID\u00a014594798.^ Benndorf R, Sun X, Gilmont RR, Biederman KJ, Molloy MP, Goodmurphy CW, Cheng H, Andrews PC, Welsh MJ (July 2001). “HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 ((3D)HSP27)”. J. Biol. Chem. 276 (29): 26753\u201361. doi:10.1074\/jbc.M103001200. PMID\u00a011342557.^ Wu Y, Liu J, Zhang Z, Huang H, Shen J, Zhang S, Jiang Y, Luo L, Yin Z (January 2009). “HSP27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitination”. Cell. Signal. 21 (1): 143\u201350. doi:10.1016\/j.cellsig.2008.10.001. PMID\u00a018950704.Further reading[edit]Concannon CG, Gorman AM, Samali A (2003). “On the role of Hsp27 in regulating apoptosis”. Apoptosis. 8 (1): 61\u201370. doi:10.1023\/A:1021601103096. PMID\u00a012510153. S2CID\u00a018464958.Elisei R, Weightman D, Kendall-Taylor P, Vassart G, Ludgate M (1993). “Muscle autoantigens in thyroid associated ophthalmopathy: the limits of molecular genetics”. J. Endocrinol. Invest. 16 (7): 533\u201340. doi:10.1007\/bf03348900. PMID\u00a08227983. S2CID\u00a023857370.Deak M, Clifton AD, Lucocq LM, Alessi DR (1998). “Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2\/p38, and may mediate activation of CREB”. EMBO J. 17 (15): 4426\u201341. doi:10.1093\/emboj\/17.15.4426. PMC\u00a01170775. PMID\u00a09687510.Sugiyama Y, Suzuki A, Kishikawa M, Akutsu R, Hirose T, Waye MM, Tsui SK, Yoshida S, Ohno S (2000). “Muscle develops a specific form of small heat shock protein complex composed of MKBP\/HSPB2 and HSPB3 during myogenic differentiation”. J. Biol. Chem. 275 (2): 1095\u2013104. doi:10.1074\/jbc.275.2.1095. PMID\u00a010625651.Baysal BE, Willett-Brozick JE, Taschner PE, Dauwerse JG, Devilee P, Devlin B (2001). “A high-resolution integrated map spanning the SDHD gene at 11q23: a 1.1-Mb BAC contig, a partial transcript map and 15 new repeat polymorphisms in a tumour-suppressor region”. Eur. J. Hum. Genet. 9 (2): 121\u20139. doi:10.1038\/sj.ejhg.5200585. PMID\u00a011313745.Nakagawa M, Tsujimoto N, Nakagawa H, Iwaki T, Fukumaki Y, Iwaki A (2001). “Association of HSPB2, a member of the small heat shock protein family, with mitochondria”. Exp. Cell Res. 271 (1): 161\u20138. doi:10.1006\/excr.2001.5362. PMID\u00a011697892.Ito H, Kamei K, Iwamoto I, Inaguma Y, Garc\u00eda-Mata R, Sztul E, Kato K (2002). “Inhibition of proteasomes induces accumulation, phosphorylation, and recruitment of HSP27 and alphaB-crystallin to aggresomes”. J. Biochem. 131 (4): 593\u2013603. doi:10.1093\/oxfordjournals.jbchem.a003139. PMID\u00a011926998.Boxman IL, Kempenaar J, de Haas E, Ponec M (2003). “Induction of HSP27 nuclear immunoreactivity during stress is modulated by vitamin C.”. Exp. Dermatol. 11 (6): 509\u201317. doi:10.1034\/j.1600-0625.2002.110603.x. PMID\u00a012473058. S2CID\u00a025384331.Patel VM, Heinel LA, Provencio JJ, Vinall PE, Kramer MS, Rosenwasser RH (2003). “Validation of image analysis for enzyme histochemical and immunocytochemical staining”. Biotechnic & Histochemistry. 77 (4): 213\u201321. doi:10.1080\/714028196. PMID\u00a012503731.Mao H, Li F, Ruchalski K, Mosser DD, Schwartz JH, Wang Y, Borkan SC (2003). “hsp72 inhibits focal adhesion kinase degradation in ATP-depleted renal epithelial cells”. J. Biol. Chem. 278 (20): 18214\u201320. doi:10.1074\/jbc.M300126200. PMID\u00a012611892.Yonekura N, Yokota S, Yonekura K, Dehari H, Arata S, Kohama G, Fujii N (2003). “Interferon-gamma downregulates Hsp27 expression and suppresses the negative regulation of cell death in oral squamous cell carcinoma lines”. Cell Death Differ. 10 (3): 313\u201322. doi:10.1038\/sj.cdd.4401169. PMID\u00a012700631.Kantham L, Kerr-Bayles L, Godde N, Quick M, Webb R, Sunderland T, Bond J, Walder K, Augert G, Collier G (2003). “Beacon interacts with cdc2\/cdc28-like kinases”. Biochem. Biophys. Res. Commun. 304 (1): 125\u20139. doi:10.1016\/S0006-291X(03)00549-7. PMID\u00a012705895.Yaglom J, O’Callaghan-Sunol C, Gabai V, Sherman MY (2003). “Inactivation of dual-specificity phosphatases is involved in the regulation of extracellular signal-regulated kinases by heat shock and hsp72”. Mol. Cell. Biol. 23 (11): 3813\u201324. doi:10.1128\/MCB.23.11.3813-3824.2003. PMC\u00a0155207. PMID\u00a012748284.Park KJ, Gaynor RB, Kwak YT (2003). “Heat shock protein 27 association with the I kappa B kinase complex regulates tumor necrosis factor alpha-induced NF-kappa B activation”. J. Biol. Chem. 278 (37): 35272\u20138. doi:10.1074\/jbc.M305095200. PMID\u00a012829720.Wen FC, Li YH, Tsai HF, Lin CH, Li C, Liu CS, Lii CK, Nukina N, Hsieh M (2003). “Down-regulation of heat shock protein 27 in neuronal cells and non-neuronal cells expressing mutant ataxin-3”. FEBS Lett. 546 (2\u20133): 307\u201314. doi:10.1016\/S0014-5793(03)00605-7. PMID\u00a012832059. S2CID\u00a035025906.Parcellier A, Schmitt E, Gurbuxani S, Seigneurin-Berny D, Pance A, Chant\u00f4me A, Plenchette S, Khochbin S, Solary E, Garrido C (2003). “HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradation”. Mol. Cell. Biol. 23 (16): 5790\u2013802. doi:10.1128\/MCB.23.16.5790-5802.2003. PMC\u00a0166315. PMID\u00a012897149.  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/hspb2-wikipedia\/#breadcrumbitem","name":"HSPB2 – Wikipedia"}}]}]