[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/human-proteome-project-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/human-proteome-project-wikipedia\/","headline":"Human Proteome Project – Wikipedia","name":"Human Proteome Project – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Scientific project coordinated by the Human Proteome Organization The Human Proteome Project[1] (HPP)","datePublished":"2021-06-09","dateModified":"2021-06-09","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/human-proteome-project-wikipedia\/","about":["Wiki"],"wordCount":3312,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Scientific project coordinated by the Human Proteome OrganizationThe Human Proteome Project[1] (HPP) is a collaborative effort coordinated by the Human Proteome Organization.[2] Its stated goal is to experimentally observe all of the proteins produced by the sequences translated from the human genome.       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Table of ContentsHistory[edit]Projects and groups[edit]Computational resources[edit]Current status[edit]See also[edit]References[edit]External links[edit]History[edit]The Human Proteome Organization has served as a coordinating body for many long-running proteomics research projects associated with specific human tissues of clinical interest, such as blood plasma,[3]liver,[4]brain[5] and urine.[6] It has also been responsible for projects associated with specific technology [7] and standards [8] necessary for the large scale study of proteins.The structure and goals of a larger project that would parallel the Human Genome Project has been debated in the scientific literature.[9][10][11][12][13] The results of this debate and a series of meetings at the World Congresses of the Human Proteome Organization in 2009, 2010 and 2011 has been the decision to define the Human Proteome Project as being composed of two sub-projects, C-HPP and B\/D-HPP.[14] The C-HPP will be organized into 25 groups, one per human chromosome. The B\/D-HPP will be organized into groups by the biological and disease relevance of proteins.[15]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Projects and groups[edit]The current set of working groups are listed below, in order of the chromosome to be studied.ChromosomeGroup leaderNational affiliation1Ping XuChina2Lydie LaneSwitzerland3Takeshi KawamuraJapan4Yu-Ju ChenTaiwan5Peter HorvatovichNetherlands6Christoph BorchersCanada7Edward NiceAustralia, New Zealand8Pengyuan YangChina9Je-Yoel ChoSeoul, Korea10Joshua LabaerUSA11Jong Shin YooKorea12Ravi SirdeshmukhIndia, Singapore, Taiwan, Thailand13Young Ki PaikKorea14Charles PineauFrance15Gilberto B DomontBrazil16Fernando CorralesSpain17Gilbert S. OmennUSA18Alex ArchakovRussia19Gy\u00f6rgy Marko-VargaSweden20Siqiu LiuChina21Albert SickmannGermany22Akhilesh PandeyUSAXYasushi IshihamaJapanYGhasem Hosseini SalekdehIranMTAndrea UrbaniItalyComputational resources[edit]Data reduction, analysis and validation of MS\/MS based proteomics results is being provided by Eric Deutsch at the Institute for Systems Biology, Seattle, USA (PeptideAtlas). Data handling associated with antibody methods is being coordinated by Kalle von Feilitzen, Stockholm, Sweden (Human Protein Atlas). Overall integration and reporting informatics are the responsibility of Lydie Lane at SIB, Geneva, Switzerland (NeXtProt). All data generated as part of HPP contributions are deposited to one of the ProteomeXchange repositories.Current status[edit]Updates on the Human Proteome Project are regularly published, e.g. in the Journal of Proteome Research (2014).[16] Metrics for the level of confidence associated with protein observations have been published[17] as has been a “MissingProteinPedia”.[18][19]Based on a comparison of nine major annotation portals gave a spread of human protein counts from 21,819 to 18,891 (as of 2017).[20] The 2021 Metrics of the HPP show that protein expression has now been credibly detected 92.8% of the predicted proteins coded in the human genome.[21]See also[edit]References[edit]^ Legrain, P.; Aebersold, Rued; Kumar, Bala; Beretta, Laura; Costello, Catherine E.; Borchers, Christoph H.; Corthals, Garry L. (29 April 2011). “The Human Proteome Project: Current State and Future Direction”. Molecular & Cellular Proteomics. 10 (7): M111.009993. doi:10.1074\/mcp.M111.009993. PMC\u00a03134076. PMID\u00a021742803.^ “HUPO (Human Proteome Organization) 1st World Congress”. Mol Cell Proteomics. American Society for Biochemistry and Molecular Biology. 9 (9): 651\u2013752. September 2002. PMID\u00a012474872.{{cite journal}}:  CS1 maint: url-status (link)^ Omenn, G.S. et al. Overview of the HUPO Plasma Proteome Project. Proteomics. 5, 3226-45 (2005).^ He, F. Human liver proteome project: plan, progress, and perspectives. Mol Cell Proteomics. 4, 1841-8 (2005).^ Hamacher, M. et al. HUPO Brain Proteome Project: toward a code of conduct. Mol Cell Proteomics. 7, 457 (2008).^ Yamamoto, T., Langham, R.G., Ronco, P., Knepper, M.A. & Thongboonkerd, V. Towards standard protocols and guidelines for urine proteomics. Proteomics. 8, 2156-9 (2008).^ Uhlen, M. & Ponten, F. Antibody-based proteomics for human tissue profiling. Mol Cell Proteomics. 4, 384-93 (2005).^ Orchard, S. et al. Current status of proteomic standards development. Expert Rev Proteomics. 1, 179-83 (2005).^ Archakov A, et al. The Moscow HUPO Human Proteome Project workshop.Mol Cell Proteomics. 8:2199-200 (2009).^ Baker MS. Building the ‘practical’ human proteome project – the next big thing in basic and clinical proteomics. Curr Opin Mol Ther. 2009 11:600-2 (2009).^ Editorial, The call of the human proteome. Nat Methods. 7:661 (2010).^ Rabilloud T., et al. Is a gene-centric human proteome project the best way for proteomics to serve biology? Proteomics. 10:3067-72 (2010).^ Editorial. A Gene-centric Human Proteome Project. Mol Cell Proteomics. 9:427-429 (2010).^ Paik, Y-K., et al. A Chromosome-Centric Human Proteome Project to Characterize the Sets of Proteins Encoded in the Genome. Nature Biotech.30: 221\u20133(2012).^ Aebersold R., et al. The Biology\/Disease-driven Human Proteome Project (B\/D-HPP): Enabling Protein Research for the Life Sciences Community. J. Proteome Res. 12:23\u201327 (2013).^ Paik Y-K., et al. Genome-wide Proteomics, Chromosome-centric Human Proteome Project (C-HPP), Part II. J. Proteome Res. 13:1\u20134 (2014).^ Omenn GS., et al. Metrics for the Human Proteome Project 2015: Progress on the Human Proteome and Guidelines for High-Confidence Protein Identification. J Proteome Res.  14:3452-60 (2015).^ Horvatovich P., et al. A Quest for Missing Proteins: update 2015 on Chromosome-Centric Human Proteome Project. J Proteome Res. Jun 15 (2015).^ Baker, MS;  et\u00a0al. (2017). “Accelerating the search for the missing proteins in the human proteome”. Nature Communications. 8: 14271. Bibcode:2017NatCo…814271B. doi:10.1038\/ncomms14271. PMC\u00a05286205. PMID\u00a028117396.^ Southan, Christopher (2017-04-07). “Last rolls of the yoyo: Assessing the human canonical protein count”. F1000Research. 6: 448. doi:10.12688\/f1000research.11119.1. ISSN\u00a02046-1402. PMC\u00a05428527. PMID\u00a028529709.^ Omenn, Gilbert S.; Lane, Lydie; Overall, Christopher M.; Paik, Young-Ki; Cristea, Ileana M.; Corrales, Fernando J.; Lindskog, Cecilia; Weintraub, Susan; Roehrl, Michael H. A.; Liu, Siqi; Bandeira, Nuno; Srivastava, Sudhir; Chen, Yu-Ju; Aebersold, Ruedi; Moritz, Robert L.; Deutsch, Eric W. (3 December 2021). “Progress Identifying and Analyzing the Human Proteome: 2021 Metrics from the HUPO Human Proteome Project”. Journal of Proteome Research. 20 (12): 5227\u20135240. doi:10.1021\/acs.jproteome.1c00590. PMC\u00a09340669. PMID\u00a034670092. S2CID\u00a0239050778.External links[edit]HPP project page (www.hupo.org)HPP web site (www.thehpp.org)Chromosome-centric HPP web site (www.c-hpp.org)BD HPP web site (www.hupo.org\/B\/D-HPP)       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/human-proteome-project-wikipedia\/#breadcrumbitem","name":"Human Proteome Project – Wikipedia"}}]}]