[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/ikzf1-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/ikzf1-wikipedia\/","headline":"IKZF1 – Wikipedia","name":"IKZF1 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens IKZF1 Identifiers Aliases IKZF1, Hs.54452, IK1, IKAROS, LYF1,","datePublished":"2016-12-14","dateModified":"2016-12-14","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/ikzf1-wikipedia\/","wordCount":11632,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensIKZF1IdentifiersAliasesIKZF1, Hs.54452, IK1, IKAROS, LYF1, LyF-1, PPP1R92, PRO0758, ZNFN1A1, CVID13, IKAROS family zinc finger 1External IDsOMIM: 603023 MGI: 1342540 HomoloGene: 55948 GeneCards: IKZF1 WikidataDNA-binding protein Ikaros also known as Ikaros family zinc finger protein 1 is a protein that in humans is encoded by the IKZF1 gene.[5][6][7]Table of ContentsIkaros – transcription factor[edit]Genes of the Ikaros Zinc Finger Family group[edit]Ikaros deficiency[edit]Interactions[edit]References[edit]Further reading[edit]External links[edit]Ikaros – transcription factor[edit]Ikaros is a transcription factor that is encoded by the IKZF genes of the Ikaros family zinc finger group. Zinc finger is a small structural motif of protein that allows protein binding to DNA or RNA molecule that is characterized by the coordination of one or more zinc ions (Zn2+) in order to stabilize the fold.Ikaros displays crucial functions in the hematopoietic system and is a known regulator of immune cells development, mainly in early B cells, CD4+ T cells. Its dysfunction has been linked to the development of chronic lymphocytic leukemia.[8][9] In particular, Ikaros has been found in recent years to be a major tumor suppressor involved in human B-cell acute lymphoblastic leukemia[8] and that it also has a part in the differentiation and function of individual T helper cells.[10]Ikaros also has a role during the later stages of B cell development during VDJ recombination in switch class of the antibody isotypes and expression of the B cell receptor.[11]In Ikaros knockout mice, T cells but not B cells are generated late in mouse development due to late compensatory expression of the related gene Aiolos (IKZF3).[12] Ikaros point mutant mice are embryonic lethal due to anemia; they have severe defects in terminal erythrocyte and granulocyte differentiation, and excessive macrophage formation.[13] SNPs located near the 3′ region of IKZF1 in humans have been linked to susceptibility to childhood acute lymphoblastic leukemia (ALL)[14] as well as type 1 diabetes.[15] The two effects appear to be in opposite directions, with the allele marking susceptibility to ALL protecting from T1D and vice versa.[15]Genes of the Ikaros Zinc Finger Family group[edit]The Ikaros Zinc Finger (IkZF) family of transcription factors are known regulators of hematopoietic cell development and many  immune cells including that of CD4+ T cells.The IkZF family consists of five members: Ikaros (encoded by the gene Ikzf1), Helios (Ikzf2), Aiolos (Ikzf3), Eos (Ikzf4), and Pegasus (Ikzf5). These factors contain N-terminal zinc finger (ZF) domains, which are responsible for mediating direct interactions with DNA, and C-terminal ZFs, which facilitate homo- and heterodimerization between IkZF family members. [16]IKZF1 is upregulated in granulocytes, B cells, CD4 and CD8 T cells, and NK cells, and downregulated in erythroblasts, megakaryocytes and monocytes.[17]Ikaros deficiency[edit]The mutation in the IKZF1 gene can cause dysfunction of the Ikaros transcription factor. The dysfunction affects expression in B cells that can lead to deregulation of the BCR signaling during B cell development and is associated with B cell transformation. The deregulation then can result in low proliferation rate and increased apoptosis of the B cells. The deregulation may be related with lymphoproliferative disorders and different forms of leukemia. [18]Interactions[edit]IKZF1 has been shown to interact with:References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000185811 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018654 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Georgopoulos K, Moore DD, Derfler B (October 1992). “Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment”. Science. 258 (5083): 808\u201312. Bibcode:1992Sci…258..808G. doi:10.1126\/science.1439790. PMID\u00a01439790.^ Hahm K, Ernst P, Lo K, Kim GS, Turck C, Smale ST (November 1994). “The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene”. Molecular and Cellular Biology. 14 (11): 7111\u201323. doi:10.1128\/mcb.14.11.7111. PMC\u00a0359245. PMID\u00a07935426.^ “Entrez Gene: IKZF1 IKAROS family zinc finger 1 (Ikaros)”.^ a b Kastner P, Chan S (June 2011). “Role of Ikaros in T-cell acute lymphoblastic leukemia”. World Journal of Biological Chemistry. 2 (6): 108\u201314. doi:10.4331\/wjbc.v2.i6.108. PMC\u00a03135856. PMID\u00a021765975.^ Oliveira VC, Lacerda MP, Moraes BB, Gomes CP, Maricato JT, Souza OF,  et\u00a0al. (July 2019). “Deregulation of Ikaros expression in B-1 cells: New insights in the malignant transformation to chronic lymphocytic leukemia”. Journal of Leukocyte Biology. 106 (3): 581\u2013594. doi:10.1002\/JLB.MA1118-454R. PMID\u00a031299112. S2CID\u00a0196350761.^ Powell MD, Read KA, Sreekumar BK, Oestreich KJ (2019). “+ T Helper Cell Differentiation”. Frontiers in Immunology. 10: 1299. doi:10.3389\/fimmu.2019.01299. PMC\u00a06563078. PMID\u00a031244845.^ Sellars M, Kastner P, Chan S (June 2011). “Ikaros in B cell development and function”. World Journal of Biological Chemistry. 2 (6): 132\u20139. doi:10.4331\/wjbc.v2.i6.132. PMC\u00a03135860. PMID\u00a021765979.^ Georgopoulos K, Winandy S, Avitahl N (1997). “The role of the Ikaros gene in lymphocyte development and homeostasis”. Annual Review of Immunology. 15: 155\u201376. doi:10.1146\/annurev.immunol.15.1.155. PMID\u00a09143685.^ Papathanasiou P, Perkins AC, Cobb BS, Ferrini R, Sridharan R, Hoyne GF,  et\u00a0al. (July 2003). “Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor”. Immunity. 19 (1): 131\u201344. doi:10.1016\/s1074-7613(03)00168-7. PMID\u00a012871645.^ Papaemmanuil E, Hosking FJ, Vijayakrishnan J, Price A, Olver B, Sheridan E,  et\u00a0al. (September 2009). “Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia”. Nature Genetics. 41 (9): 1006\u201310. doi:10.1038\/ng.430. PMC\u00a04915548. PMID\u00a019684604.^ a b Swafford AD, Howson JM, Davison LJ, Wallace C, Smyth DJ, Schuilenburg H,  et\u00a0al. (March 2011). “An allele of IKZF1 (Ikaros) conferring susceptibility to childhood acute lymphoblastic leukemia protects against type 1 diabetes”. Diabetes. 60 (3): 1041\u20134. doi:10.2337\/db10-0446. PMC\u00a03046822. PMID\u00a021270240.^ Powell MD, Read KA, Sreekumar BK, Oestreich KJ (2019-06-06). “+ T Helper Cell Differentiation”. Frontiers in Immunology. 10: 1299. doi:10.3389\/fimmu.2019.01299. PMC\u00a06563078. PMID\u00a031244845.^ Watkins NA, Gusnanto A, de Bono B, De S, Miranda-Saavedra D, Hardie DL,  et\u00a0al. (May 2009). “A HaemAtlas: characterizing gene expression in differentiated human blood cells”. Blood. 113 (19): e1-9. doi:10.1182\/blood-2008-06-162958. PMC\u00a02680378. PMID\u00a019228925.^ Oliveira VC, Lacerda MP, Moraes BB, Gomes CP, Maricato JT, Souza OF,  et\u00a0al. (July 2019). “Deregulation of Ikaros expression in B-1 cells: New insights in the malignant transformation to chronic lymphocytic leukemia”. Journal of Leukocyte Biology. 106 (3): 581\u2013594. doi:10.1002\/JLB.MA1118-454R. PMID\u00a031299112. S2CID\u00a0196350761.^ Koipally J, Georgopoulos K (June 2000). “Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity”. The Journal of Biological Chemistry. 275 (26): 19594\u2013602. doi:10.1074\/jbc.M000254200. PMID\u00a010766745.^ a b c d Koipally J, Renold A, Kim J, Georgopoulos K (June 1999). “Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes”. The EMBO Journal. 18 (11): 3090\u2013100. doi:10.1093\/emboj\/18.11.3090. PMC\u00a01171390. PMID\u00a010357820.^ a b c d e Koipally J, Georgopoulos K (August 2002). “A molecular dissection of the repression circuitry of Ikaros”. The Journal of Biological Chemistry. 277 (31): 27697\u2013705. doi:10.1074\/jbc.M201694200. PMID\u00a012015313.^ Kelley CM, Ikeda T, Koipally J, Avitahl N, Wu L, Georgopoulos K, Morgan BA (April 1998). “Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors”. Current Biology. 8 (9): 508\u201315. doi:10.1016\/s0960-9822(98)70202-7. PMID\u00a09560339. S2CID\u00a017835058.^ Morgan B, Sun L, Avitahl N, Andrikopoulos K, Ikeda T, Gonzales E,  et\u00a0al. (April 1997). “Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation”. The EMBO Journal. 16 (8): 2004\u201313. doi:10.1093\/emboj\/16.8.2004. PMC\u00a01169803. PMID\u00a09155026.^ Kim J, Sif S, Jones B, Jackson A, Koipally J, Heller E,  et\u00a0al. (March 1999). “Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes”. Immunity. 10 (3): 345\u201355. doi:10.1016\/s1074-7613(00)80034-5. PMID\u00a010204490.^ Honma Y, Kiyosawa H, Mori T, Oguri A, Nikaido T, Kanazawa K,  et\u00a0al. (March 1999). “Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system”. FEBS Letters. 447 (1): 76\u201380. doi:10.1016\/s0014-5793(99)00265-3. PMID\u00a010218586. S2CID\u00a028898354.^ Perdomo J, Holmes M, Chong B, Crossley M (December 2000). “Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities”. The Journal of Biological Chemistry. 275 (49): 38347\u201354. doi:10.1074\/jbc.M005457200. PMID\u00a010978333.^ Koipally J, Georgopoulos K (June 2002). “Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression”. The Journal of Biological Chemistry. 277 (26): 23143\u20139. doi:10.1074\/jbc.M202079200. PMID\u00a011959865.^ Katsumura KR, Bresnick EH (April 2017). “The GATA factor revolution in hematology”. Blood. 129 (15): 2092\u20132102. doi:10.1182\/blood-2016-09-687871. PMC\u00a05391619. PMID\u00a028179282.Further reading[edit]Tonnelle C, Calmels B, Maroc C, Gabert J, Chabannon C (January 2002). “Ikaros gene expression and leukemia”. Leukemia & Lymphoma. 43 (1): 29\u201335. doi:10.1080\/10428190210186. PMID\u00a011908734. S2CID\u00a023932398.Westman BJ, Mackay JP, Gell D (October 2002). “Ikaros: a key regulator of haematopoiesis”. The International Journal of Biochemistry & Cell Biology. 34 (10): 1304\u20137. doi:10.1016\/S1357-2725(02)00070-5. PMID\u00a012127581.Moln\u00e1r A, Wu P, Largespada DA, Vortkamp A, Scherer S, Copeland NG,  et\u00a0al. (January 1996). “The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse”. Journal of Immunology. 156 (2): 585\u201392. PMID\u00a08543809.Nietfeld W, Meyerhans A (January 1996). “Cloning and sequencing of hIk-1, a cDNA encoding a human homologue of mouse Ikaros\/LyF-1”. Immunology Letters. 49 (1\u20132): 139\u201341. doi:10.1016\/0165-2478(95)02479-4. PMID\u00a08964602.Morgan B, Sun L, Avitahl N, Andrikopoulos K, Ikeda T, Gonzales E,  et\u00a0al. (April 1997). “Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation”. The EMBO Journal. 16 (8): 2004\u201313. doi:10.1093\/emboj\/16.8.2004. PMC\u00a01169803. PMID\u00a09155026.Kelley CM, Ikeda T, Koipally J, Avitahl N, Wu L, Georgopoulos K, Morgan BA (April 1998). “Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors”. Current Biology. 8 (9): 508\u201315. doi:10.1016\/S0960-9822(98)70202-7. PMID\u00a09560339. S2CID\u00a017835058.Sun L, Heerema N, Crotty L, Wu X, Navara C, Vassilev A,  et\u00a0al. (January 1999). “Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia”. Proceedings of the National Academy of Sciences of the United States of America. 96 (2): 680\u20135. Bibcode:1999PNAS…96..680S. doi:10.1073\/pnas.96.2.680. PMC\u00a015196. PMID\u00a09892693.Kim J, Sif S, Jones B, Jackson A, Koipally J, Heller E,  et\u00a0al. (March 1999). “Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes”. Immunity. 10 (3): 345\u201355. doi:10.1016\/S1074-7613(00)80034-5. PMID\u00a010204490.Honma Y, Kiyosawa H, Mori T, Oguri A, Nikaido T, Kanazawa K,  et\u00a0al. (March 1999). “Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system”. FEBS Letters. 447 (1): 76\u201380. doi:10.1016\/S0014-5793(99)00265-3. PMID\u00a010218586. S2CID\u00a028898354.Koipally J, Renold A, Kim J, Georgopoulos K (June 1999). “Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes”. The EMBO Journal. 18 (11): 3090\u2013100. doi:10.1093\/emboj\/18.11.3090. PMC\u00a01171390. PMID\u00a010357820.Sun L, Goodman PA, Wood CM, Crotty ML, Sensel M, Sather H,  et\u00a0al. (December 1999). “Expression of aberrantly spliced oncogenic ikaros isoforms in childhood acute lymphoblastic leukemia”. Journal of Clinical Oncology. 17 (12): 3753\u201366. doi:10.1200\/JCO.1999.17.12.3753. PMID\u00a010577847.Hosokawa Y, Maeda Y, Ichinohasama R, Miura I, Taniwaki M, Seto M (April 2000). “The Ikaros gene, a central regulator of lymphoid differentiation, fuses to the BCL6 gene as a result of t(3;7)(q27;p12) translocation in a patient with diffuse large B-cell lymphoma”. Blood. 95 (8): 2719\u201321. doi:10.1182\/blood.V95.8.2719. PMID\u00a010753856.Koipally J, Georgopoulos K (June 2000). “Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity”. The Journal of Biological Chemistry. 275 (26): 19594\u2013602. doi:10.1074\/jbc.M000254200. PMID\u00a010766745.Perdomo J, Holmes M, Chong B, Crossley M (December 2000). “Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities”. The Journal of Biological Chemistry. 275 (49): 38347\u201354. doi:10.1074\/jbc.M005457200. PMID\u00a010978333.Payne KJ, Nicolas JH, Zhu JY, Barsky LW, Crooks GM (August 2001). “Cutting edge: predominant expression of a novel Ikaros isoform in normal human hemopoiesis”. Journal of Immunology. 167 (4): 1867\u201370. doi:10.4049\/jimmunol.167.4.1867. PMID\u00a011489963.Koipally J, Heller EJ, Seavitt JR, Georgopoulos K (April 2002). “Unconventional potentiation of gene expression by Ikaros”. The Journal of Biological Chemistry. 277 (15): 13007\u201315. doi:10.1074\/jbc.M111371200. PMID\u00a011799125.Dorsam G, Goetzl EJ (April 2002). “Vasoactive intestinal peptide receptor-1 (VPAC-1) is a novel gene target of the hemolymphopoietic transcription factor Ikaros”. The Journal of Biological Chemistry. 277 (16): 13488\u201393. doi:10.1074\/jbc.M107922200. PMID\u00a011812772.External links[edit]  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/ikzf1-wikipedia\/#breadcrumbitem","name":"IKZF1 – Wikipedia"}}]}]