[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/inosine-monophosphate-synthase-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/inosine-monophosphate-synthase-wikipedia\/","headline":"Inosine monophosphate synthase – Wikipedia","name":"Inosine monophosphate synthase – Wikipedia","description":"From Wikipedia, the free encyclopedia Mammalian protein found in Homo sapiens Bifunctional purine biosynthesis protein PURH is a protein that","datePublished":"2018-11-08","dateModified":"2018-11-08","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/a\/a5\/PDB_1p4r_EBI.jpg\/180px-PDB_1p4r_EBI.jpg","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/a\/a5\/PDB_1p4r_EBI.jpg\/180px-PDB_1p4r_EBI.jpg","height":"135","width":"180"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/inosine-monophosphate-synthase-wikipedia\/","wordCount":5517,"articleBody":"From Wikipedia, the free encyclopediaMammalian protein found in Homo sapiensBifunctional purine biosynthesis protein PURH is a protein that in humans is encoded by the ATIC gene.[5][6][7]ATIC encodes an enzyme which generates inosine monophosphate from aminoimidazole carboxamide ribonucleotide.It has two functions:EC 2.1.2.3 – 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferaseEC 3.5.4.10 – IMP cyclohydrolaseReferences[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000138363 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026192 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Rayl EA, Moroson BA, Beardsley GP (Mar 1996). “The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase\/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping”. J Biol Chem. 271 (4): 2225\u201333. doi:10.1074\/jbc.271.4.2225. PMID\u00a08567683.^ Sugita T, Aya H, Ueno M, Ishizuka T, Kawashima K (Nov 1997). “Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase”. J Biochem. 122 (2): 309\u201313. doi:10.1093\/oxfordjournals.jbchem.a021754. PMID\u00a09378707.^ “Entrez Gene: ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase\/IMP cyclohydrolase”.Further reading[edit]ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}]]>Rasmussen HH, van Damme J, Puype M,  et\u00a0al. (1993). “Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes”. Electrophoresis. 13 (12): 960\u20139. doi:10.1002\/elps.11501301199. PMID\u00a01286667. S2CID\u00a041855774.Yamauchi M, Seki N, Mita K,  et\u00a0al. (1996). “Isolation of human purH gene expressed in the rodent transformant cells by subtractive enrichment of 3′-untranslated region of human transcript”. DNA Res. 2 (6): 269\u201375. doi:10.1093\/dnares\/2.6.269. PMID\u00a08867801.Beardsley GP, Rayl EA, Gunn K,  et\u00a0al. (1998). “Structure and functional relationships in human pur H”. Adv. Exp. Med. Biol. Advances in Experimental Medicine and Biology. 431: 221\u20136. doi:10.1007\/978-1-4615-5381-6_43. ISBN\u00a0978-0-306-45778-4. PMID\u00a09598063.Vergis JM, Bulock KG, Fleming KG, Beardsley GP (2001). “Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase\/inosine 5′-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity”. J. Biol. Chem. 276 (11): 7727\u201333. doi:10.1074\/jbc.M009940200. PMID\u00a011096114.Bulock KG, Beardsley GP, Anderson KS (2002). “The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase\/inosine 5′-monophosphate cyclohydrolase). A surprising lack of substrate channeling”. J. Biol. Chem. 277 (25): 22168\u201374. doi:10.1074\/jbc.M111964200. PMID\u00a011948179.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Cheong CG, Wolan DW, Greasley SE,  et\u00a0al. (2004). “Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase\/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates”. J. Biol. Chem. 279 (17): 18034\u201345. doi:10.1074\/jbc.M313691200. PMID\u00a014966129.Marie S, Heron B, Bitoun P,  et\u00a0al. (2004). “AICA-Ribosiduria: A Novel, Neurologically Devastating Inborn Error of Purine Biosynthesis Caused by Mutation of ATIC”. Am. J. Hum. Genet. 74 (6): 1276\u201381. doi:10.1086\/421475. PMC\u00a01182092. PMID\u00a015114530.Dervieux T, Furst D, Lein DO,  et\u00a0al. (2004). “Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis”. Arthritis Rheum. 50 (9): 2766\u201374. doi:10.1002\/art.20460. PMID\u00a015457444.Gerhard DS, Wagner L, Feingold EA,  et\u00a0al. (2004). “The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121\u20137. doi:10.1101\/gr.2596504. PMC\u00a0528928. PMID\u00a015489334.Ewing RM, Chu P, Elisma F,  et\u00a0al. (2007). “Large-scale mapping of human protein\u2013protein interactions by mass spectrometry”. Mol. Syst. Biol. 3 (1): 89. doi:10.1038\/msb4100134. PMC\u00a01847948. PMID\u00a017353931.External links[edit]li{counter-increment:listitem}.mw-parser-output .hlist ol>li::before{content:\" \"counter(listitem)\"a0 \"}.mw-parser-output .hlist dd ol>li:first-child::before,.mw-parser-output .hlist dt ol>li:first-child::before,.mw-parser-output .hlist li ol>li:first-child::before{content:\" (\"counter(listitem)\"a0 \"}]]>.navbox-abovebelow,.mw-parser-output tr+tr>.navbox-group,.mw-parser-output tr+tr>.navbox-image,.mw-parser-output tr+tr>.navbox-list{border-top:2px solid #fdfdfd}.mw-parser-output .navbox-title{background-color:#ccf}.mw-parser-output .navbox-abovebelow,.mw-parser-output .navbox-group,.mw-parser-output .navbox-subgroup .navbox-title{background-color:#ddf}.mw-parser-output .navbox-subgroup .navbox-group,.mw-parser-output .navbox-subgroup .navbox-abovebelow{background-color:#e6e6ff}.mw-parser-output .navbox-even{background-color:#f7f7f7}.mw-parser-output .navbox-odd{background-color:transparent}.mw-parser-output .navbox .hlist td dl,.mw-parser-output .navbox .hlist td ol,.mw-parser-output .navbox .hlist td ul,.mw-parser-output .navbox td.hlist dl,.mw-parser-output .navbox td.hlist ol,.mw-parser-output .navbox td.hlist ul{padding:0.125em 0}.mw-parser-output .navbox .navbar{display:block;font-size:100%}.mw-parser-output .navbox-title .navbar{float:left;text-align:left;margin-right:0.5em}]]>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}]]>PDB gallery1p4r: Crystal Structure of Human ATIC in complex with folate-based inhibitor BW1540U88UD1pkx: Crystal Structure of human ATIC in complex with XMP1pl0: Crystal structure of human ATIC in complex with folate-based inhibitor, BW2315U89UCWikimedia ErrorOur servers are currently under maintenance or experiencing a technical problem.Please try again in a few\u00a0minutes.See the error message at the bottom of this page for more\u00a0information. 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