[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/integrin-alpha-10-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/integrin-alpha-10-wikipedia\/","headline":"Integrin alpha 10 &#8211; Wikipedia","name":"Integrin alpha 10 &#8211; Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Integrin alpha-10 also known as ITGA10","datePublished":"2017-05-24","dateModified":"2017-05-24","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/integrin-alpha-10-wikipedia\/","wordCount":3640,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensIntegrin alpha-10 also known as ITGA10 is a protein that in humans is encoded by the ITGA10  gene.[5][6][7]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Table of ContentsFunction[edit]Related gene problems[edit]References[edit]Further reading[edit]External links[edit]Function[edit]Integrins are integral membrane proteins composed of an alpha chain and a beta chain, and are known to participate in cell adhesion as well as cell-surface mediated signalling. The I-domain containing alpha 10 combines with the integrin beta 1 chain (ITGB1) to form a novel collagen type II-binding integrin expressed in cartilage tissue.[5]Related gene problems[edit]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000143127 &#8211; Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000090210 &#8211; Ensembl, May 2017^ &#8220;Human PubMed Reference:&#8221;. National Center for Biotechnology Information, U.S. National Library of Medicine.^ &#8220;Mouse PubMed Reference:&#8221;. National Center for Biotechnology Information, U.S. National Library of Medicine.^ a b &#8220;Entrez Gene: ITGA10 integrin, alpha 10&#8221;.^ Camper L, Hellman U, Lundgren-Akerlund E (August 1998). &#8220;Isolation, cloning, and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes&#8221;. J. Biol. Chem. 273 (32): 20383\u20139. doi:10.1074\/jbc.273.32.20383. PMID\u00a09685391.^ Lehnert K, Ni J, Leung E, Gough S, Morris CM, Liu D, Wang SX, Langley R, Krissansen GW (1999). &#8220;The integrin alpha10 subunit: expression pattern, partial gene structure, and chromosomal localization&#8221;. Cytogenet. Cell Genet. 87 (3\u20134): 238\u201344. doi:10.1159\/000015434. PMID\u00a010702680. S2CID\u00a085257405.^ Klopocki E, Schulze H, Strauss G,  et\u00a0al. (February 2007). &#8220;Complex Inheritance Pattern Resembling Autosomal Recessive Inheritance Involving a Microdeletion in Thrombocytopenia\u2013Absent Radius Syndrome&#8221;. Am. J. Hum. Genet. 80 (2): 232\u201340. doi:10.1086\/510919. PMC\u00a01785342. PMID\u00a017236129.Further reading[edit]Camper L, Hellman U, Lundgren-Akerlund E (1998). &#8220;Isolation, cloning, and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes&#8221;. J. Biol. Chem. 273 (32): 20383\u20139. doi:10.1074\/jbc.273.32.20383. PMID\u00a09685391.Bengtsson T, Camper L, Schneller M, Lundgren-Akerlund E (2001). &#8220;Characterization of the mouse integrin subunit alpha10 gene and comparison with its human homologue. Genomic structure, chromosomal localization and identification of splice variants&#8221;. Matrix Biol. 20 (8): 565\u201376. doi:10.1016\/S0945-053X(01)00164-0. PMID\u00a011731273.Brakebusch C, Hirsch E, Potocnik A, F\u00e4ssler R (1997). &#8220;Genetic analysis of beta1 integrin function: confirmed, new and revised roles for a crucial family of cell adhesion molecules&#8221;. J. Cell Sci. 110 (23): 2895\u2013904. doi:10.1242\/jcs.110.23.2895. PMID\u00a09359872.Clark HF, Gurney AL, Abaya E,  et\u00a0al. (2003). &#8220;The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment&#8221;. Genome Res. 13 (10): 2265\u201370. doi:10.1101\/gr.1293003. PMC\u00a0403697. PMID\u00a012975309.Lehnert K, Ni J, Leung E,  et\u00a0al. (1999). &#8220;The integrin alpha10 subunit: expression pattern, partial gene structure, and chromosomal localization&#8221;. Cytogenet. Cell Genet. 87 (3\u20134): 238\u201344. doi:10.1159\/000015434. PMID\u00a010702680. S2CID\u00a085257405.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2002). &#8220;Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences&#8221;. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS&#8230;9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Svoboda KK (1998). &#8220;Chondrocyte-matrix attachment complexes mediate survival and differentiation&#8221;. Microsc. Res. Tech. 43 (2): 111\u201322. doi:10.1002\/(SICI)1097-0029(19981015)43:23.0.CO;2-O. PMID\u00a09822998. S2CID\u00a015611353.Bengtsson T, Aszodi A, Nicolae C,  et\u00a0al. (2005). &#8220;Loss of alpha10beta1 integrin expression leads to moderate dysfunction of growth plate chondrocytes&#8221;. J. Cell Sci. 118 (Pt 5): 929\u201336. doi:10.1242\/jcs.01678. PMID\u00a015713743.Wenke AK, Rothhammer T, Moser M, Bosserhoff AK (2006). &#8220;Regulation of integrin alpha10 expression in chondrocytes by the transcription factors AP-2epsilon and Ets-1&#8221;. Biochem. Biophys. Res. Commun. 345 (1): 495\u2013501. doi:10.1016\/j.bbrc.2006.04.123. PMID\u00a016684505.External links[edit]This article incorporates text from the United States National Library of Medicine, which is in the public domain.       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