[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/integrin-beta-4-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/integrin-beta-4-wikipedia\/","headline":"Integrin beta 4 – Wikipedia","name":"Integrin beta 4 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens ITGB4 Available structures PDB Ortholog search:","datePublished":"2015-09-13","dateModified":"2015-09-13","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/1\/1a\/Protein_ITGB4_PDB_1qg3.png\/250px-Protein_ITGB4_PDB_1qg3.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/1\/1a\/Protein_ITGB4_PDB_1qg3.png\/250px-Protein_ITGB4_PDB_1qg3.png","height":"180","width":"250"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/integrin-beta-4-wikipedia\/","about":["Wiki"],"wordCount":7895,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensITGB4Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1QG3, 2YRZ, 3F7P, 3F7Q, 3F7R, 3FQ4, 3FSO, 3H6A, 4Q58, 4WTW, 4WTX       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4IdentifiersAliasesITGB4, CD104, GP150, integrin subunit beta 4, JEB5A, JEB5BExternal IDsOMIM: 147557 MGI: 96613 HomoloGene: 179 GeneCards: ITGB4 WikidataIntegrin, beta 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a human gene.[5]Table of ContentsFunction[edit]Interactions[edit]See also[edit]References[edit]Further reading[edit]External links[edit]Function[edit]Integrins are heterodimers composed of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[5]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Interactions[edit]ITGB4 has been shown to interact with Collagen, type XVII, alpha 1,[6][7]EIF6[8] and Erbin.[9]See also[edit]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000132470 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020758 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ a b “Entrez Gene: ITGB4 integrin, beta 4”.^ Aho S, Uitto J (Feb 1998). “Direct interaction between the intracellular domains of bullous pemphigoid antigen 2 (BP180) and beta 4 integrin, hemidesmosomal components of basal keratinocytes”. Biochemical and Biophysical Research Communications. 243 (3): 694\u20139. doi:10.1006\/bbrc.1998.8162. PMID\u00a09500991.^ Schaapveld RQ, Borradori L, Geerts D, van Leusden MR, Kuikman I, Nievers MG, Niessen CM, Steenbergen RD, Snijders PJ, Sonnenberg A (Jul 1998). “Hemidesmosome formation is initiated by the beta4 integrin subunit, requires complex formation of beta4 and HD1\/plectin, and involves a direct interaction between beta4 and the bullous pemphigoid antigen 180”. The Journal of Cell Biology. 142 (1): 271\u201384. doi:10.1083\/jcb.142.1.271. PMC\u00a02133016. PMID\u00a09660880.^ Biffo S, Sanvito F, Costa S, Preve L, Pignatelli R, Spinardi L, Marchisio PC (Nov 1997). “Isolation of a novel beta4 integrin-binding protein (p27(BBP)) highly expressed in epithelial cells”. The Journal of Biological Chemistry. 272 (48): 30314\u201321. doi:10.1074\/jbc.272.48.30314. PMID\u00a09374518.^ Favre B, Fontao L, Koster J, Shafaatian R, Jaunin F, Saurat JH, Sonnenberg A, Borradori L (Aug 2001). “The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression”. The Journal of Biological Chemistry. 276 (35): 32427\u201336. doi:10.1074\/jbc.M011005200. PMID\u00a011375975.Further reading[edit]Lipscomb EA, Mercurio AM (Sep 2005). “Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression”. Cancer and Metastasis Reviews. 24 (3): 413\u201323. doi:10.1007\/s10555-005-5133-4. PMID\u00a016258729. S2CID\u00a026150860.Sonnenberg A, Linders CJ, Modderman PW, Damsky CH, Aumailley M, Timpl R (Jun 1990). “Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8”. The Journal of Cell Biology. 110 (6): 2145\u201355. doi:10.1083\/jcb.110.6.2145. PMC\u00a02116116. PMID\u00a01693624.Tamura RN, Rozzo C, Starr L, Chambers J, Reichardt LF, Cooper HM, Quaranta V (Oct 1990). “Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4”. The Journal of Cell Biology. 111 (4): 1593\u2013604. doi:10.1083\/jcb.111.4.1593. PMC\u00a02116232. PMID\u00a01976638.Hogervorst F, Kuikman I, van Kessel AG, Sonnenberg A (Jul 1991). “Molecular cloning of the human alpha 6 integrin subunit. Alternative splicing of alpha 6 mRNA and chromosomal localization of the alpha 6 and beta 4 genes”. European Journal of Biochemistry. 199 (2): 425\u201333. doi:10.1111\/j.1432-1033.1991.tb16140.x. PMID\u00a02070796.Vogel BE, Tarone G, Giancotti FG, Gailit J, Ruoslahti E (Apr 1990). “A novel fibronectin receptor with an unexpected subunit composition (alpha v beta 1)”. The Journal of Biological Chemistry. 265 (11): 5934\u20137. doi:10.1016\/S0021-9258(19)39268-3. PMID\u00a02138612.Suzuki S, Naitoh Y (Mar 1990). “Amino acid sequence of a novel integrin beta 4 subunit and primary expression of the mRNA in epithelial cells”. The EMBO Journal. 9 (3): 757\u201363. doi:10.1002\/j.1460-2075.1990.tb08170.x. PMC\u00a0551732. PMID\u00a02311577.Hogervorst F, Kuikman I, von dem Borne AE, Sonnenberg A (Mar 1990). “Cloning and sequence analysis of beta-4 cDNA: an integrin subunit that contains a unique 118 kd cytoplasmic domain”. The EMBO Journal. 9 (3): 765\u201370. doi:10.1002\/j.1460-2075.1990.tb08171.x. PMC\u00a0551734. PMID\u00a02311578.Kajiji S, Tamura RN, Quaranta V (Mar 1989). “A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors”. The EMBO Journal. 8 (3): 673\u201380. doi:10.1002\/j.1460-2075.1989.tb03425.x. PMC\u00a0400860. PMID\u00a02542022.Hemler ME, Crouse C, Sonnenberg A (Apr 1989). “Association of the VLA alpha 6 subunit with a novel protein. A possible alternative to the common VLA beta 1 subunit on certain cell lines”. The Journal of Biological Chemistry. 264 (11): 6529\u201335. doi:10.1016\/S0021-9258(18)83380-4. PMID\u00a02649503.Vidal F, Aberdam D, Miquel C, Christiano AM, Pulkkinen L, Uitto J, Ortonne JP, Meneguzzi G (Jun 1995). “Integrin beta 4 mutations associated with junctional epidermolysis bullosa with pyloric atresia”. Nature Genetics. 10 (2): 229\u201334. doi:10.1038\/ng0695-229. PMID\u00a07545057. S2CID\u00a024894174.Mainiero F, Pepe A, Wary KK, Spinardi L, Mohammadi M, Schlessinger J, Giancotti FG (Sep 1995). “Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc\/Grb2 and association with the cytoskeleton of hemidesmosomes”. The EMBO Journal. 14 (18): 4470\u201381. doi:10.1002\/j.1460-2075.1995.tb00126.x. PMC\u00a0394539. PMID\u00a07556090.Clarke AS, Lotz MM, Mercurio AM (Apr 1994). “A novel structural variant of the human beta 4 integrin cDNA”. Cell Adhesion and Communication. 2 (1): 1\u20136. doi:10.3109\/15419069409014197. PMID\u00a07982032.Weeks BS, Desai K, Loewenstein PM, Klotman ME, Klotman PE, Green M, Kleinman HK (Mar 1993). “Identification of a novel cell attachment domain in the HIV-1 Tat protein and its 90-kDa cell surface binding protein”. The Journal of Biological Chemistry. 268 (7): 5279\u201384. doi:10.1016\/S0021-9258(18)53530-4. PMID\u00a08444901.Iacovacci S, Gagnoux-Palacios L, Zambruno G, Meneguzzi G, D’Alessio M (Jun 1997). “Genomic organization of the human integrin beta4 gene”. Mammalian Genome. 8 (6): 448\u201350. doi:10.1007\/s003359900467. PMID\u00a09166594. S2CID\u00a041037975.Mainiero F, Murgia C, Wary KK, Curatola AM, Pepe A, Blumemberg M, Westwick JK, Der CJ, Giancotti FG (May 1997). “The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation”. The EMBO Journal. 16 (9): 2365\u201375. doi:10.1093\/emboj\/16.9.2365. PMC\u00a01169837. PMID\u00a09171350.Pulkkinen L, Kurtz K, Xu Y, Bruckner-Tuderman L, Uitto J (Jun 1997). “Genomic organization of the integrin beta 4 gene (ITGB4): a homozygous splice-site mutation in a patient with junctional epidermolysis bullosa associated with pyloric atresia”. Laboratory Investigation. 76 (6): 823\u201333. PMID\u00a09194858.van Leusden MR, Kuikman I, Sonnenberg A (Jun 1997). “The unique cytoplasmic domain of the human integrin variant beta4E is produced by partial retention of intronic sequences”. Biochemical and Biophysical Research Communications. 235 (3): 826\u201330. doi:10.1006\/bbrc.1997.6892. PMID\u00a09207246.von Bredow DC, Nagle RB, Bowden GT, Cress AE (Oct 1997). “Cleavage of beta 4 integrin by matrilysin”. Experimental Cell Research. 236 (1): 341\u20135. doi:10.1006\/excr.1997.3711. PMID\u00a09344615.Biffo S, Sanvito F, Costa S, Preve L, Pignatelli R, Spinardi L, Marchisio PC (Nov 1997). “Isolation of a novel beta4 integrin-binding protein (p27(BBP)) highly expressed in epithelial cells”. The Journal of Biological Chemistry. 272 (48): 30314\u201321. doi:10.1074\/jbc.272.48.30314. PMID\u00a09374518.Pulkkinen L, Kim DU, Uitto J (Jan 1998). “Epidermolysis bullosa with pyloric atresia: novel mutations in the beta4 integrin gene (ITGB4)”. The American Journal of Pathology. 152 (1): 157\u201366. PMC\u00a01858138. PMID\u00a09422533.Hughes AE, Bradley DT, Campbell M, Lechner J, Dash DP, Simpson DA, Willoughby CE (Nov 2011). “Mutation altering the miR-184 seed region causes familial keratoconus with cataract”. American Journal of Human Genetics. 89 (5): 628\u201333. doi:10.1016\/j.ajhg.2011.09.014. PMC\u00a03213395. PMID\u00a021996275.External links[edit]This article incorporates text from the United States National Library of Medicine, which is in the public domain.PDB gallery1qg3: CRYSTAL STRUCTURE OF A TANDEM PAIR OF FIBRONECTIN TYPE III DOMAINS FROM THE CYTOPLASMIC TAIL OF INTEGRIN ALPHA6 BETA4       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/integrin-beta-4-wikipedia\/#breadcrumbitem","name":"Integrin beta 4 – Wikipedia"}}]}]