[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/integrin-beta-7-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/integrin-beta-7-wikipedia\/","headline":"Integrin beta 7 – Wikipedia","name":"Integrin beta 7 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Integrin beta-7 is an integrin protein that in humans is encoded by the","datePublished":"2020-02-04","dateModified":"2020-02-04","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/8\/8d\/PDB_2brq_EBI.jpg\/180px-PDB_2brq_EBI.jpg","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/8\/8d\/PDB_2brq_EBI.jpg\/180px-PDB_2brq_EBI.jpg","height":"123","width":"180"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/integrin-beta-7-wikipedia\/","wordCount":6621,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene.[5][6] It can pair with ITGA4 (CD49d) to form the heterodimeric integrin receptor \u03b14\u03b27, or with ITGAE (CD103) to form \u03b1E\u03b27.[7]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Table of ContentsStructure[edit]Interactions[edit]References[edit]Further reading[edit]External links[edit]Structure[edit]Like all integrin subunits, \u03b27 is a highly flexible, membrane-bound, extracellular protein that must pair with an \u03b1 subunit for stability. The molecule’s flexibility allows it to dynamically regulate its affinity for ligand through conformational changes.[8] Beginning with the apical end of the protein, farthest from the cell membrane, the \u03b27 is composed of a head and upper legs, collectively known as the headpiece, lower legs, a transmembrane domain and a cytoplasmic tail. The top of the head is the I-like domain, sometimes called the \u03b2I domain, which, in combination with the \u03b1 subunit, binds ligand. Just below this is the hybrid domain, a portion of which is N-terminal to the I-like domain.  Below the hybrid domain is the PSI domain, which completes the headpiece.  The lower legs consist of EGF domains 1-4 and the \u03b2 tail domain. Finally there is a transmembrane domain, and the C-terminal cytoplasmic tail.[9]Interactions[edit]ITGB7 has been shown to interact with EED.[10]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000139626 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001281 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Erle DJ, R\u00fcegg C, Sheppard D, Pytela R (Jun 1991). “Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes”. The Journal of Biological Chemistry. 266 (17): 11009\u201316. doi:10.1016\/S0021-9258(18)99120-9. PMID\u00a02040616.^ “Entrez Gene: ITGB7 integrin, beta 7”.^ Byron A, Humphries JD, Askari JA, Craig SE, Mould AP, Humphries MJ (Nov 2009). “Anti-integrin monoclonal antibodies”. Journal of Cell Science. 122 (Pt 22): 4009\u201311. doi:10.1242\/jcs.056770. PMC\u00a03329622. PMID\u00a019910492.^ Carman CV, Springer TA (Oct 2003). “Integrin avidity regulation: are changes in affinity and conformation underemphasized?”. Current Opinion in Cell Biology. 15 (5): 547\u201356. doi:10.1016\/j.ceb.2003.08.003. PMID\u00a014519389.^ Yu Y, Zhu J, Mi LZ, Walz T, Sun H, Chen J, Springer TA (Jan 2012). “Structural specializations of \u03b1(4)\u03b2(7), an integrin that mediates rolling adhesion”. The Journal of Cell Biology. 196 (1): 131\u201346. doi:10.1083\/jcb.201110023. PMC\u00a03255974. PMID\u00a022232704.^ Rietzler M, Bittner M, Kolanus W, Schuster A, Holzmann B (Oct 1998). “The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins”. The Journal of Biological Chemistry. 273 (42): 27459\u201366. doi:10.1074\/jbc.273.42.27459. PMID\u00a09765275.Further reading[edit]R\u00fcegg C, Postigo AA, Sikorski EE, Butcher EC, Pytela R, Erle DJ (Apr 1992). “Role of integrin alpha 4 beta 7\/alpha 4 beta P in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering”. The Journal of Cell Biology. 117 (1): 179\u201389. doi:10.1083\/jcb.117.1.179. PMC\u00a02289398. PMID\u00a01372909.Chan BM, Elices MJ, Murphy E, Hemler ME (Apr 1992). “Adhesion to vascular cell adhesion molecule 1 and fibronectin. Comparison of alpha 4 beta 1 (VLA-4) and alpha 4 beta 7 on the human B cell line JY”. The Journal of Biological Chemistry. 267 (12): 8366\u201370. doi:10.1016\/S0021-9258(18)42453-2. PMID\u00a01373725.Jiang WM, Jenkins D, Yuan Q, Leung E, Choo KH, Watson JD, Krissansen GW (Sep 1992). “The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1”. International Immunology. 4 (9): 1031\u201340. doi:10.1093\/intimm\/4.9.1031. PMID\u00a01382574.Baker E, Sutherland GR, Jiang WM, Yuan Q, Leung E, Watson JD, Krissansen GW (1992). “Mapping of the human integrin beta 7 gene (ITG beta 7) to 12q13.13 by non-isotopic in situ hybridization”. Mammalian Genome. 2 (4): 272\u20133. doi:10.1007\/BF00355438. PMID\u00a01543919. S2CID\u00a030346801.Yuan QA, Jiang WM, Krissansen GW, Watson JD (Dec 1991). “Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains”. International Immunology. 3 (12): 1373\u20134. doi:10.1093\/intimm\/3.12.1373. PMID\u00a01777426.Yuan QA, Jiang WM, Krissansen GW, Watson JD (1991). “Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains”. International Immunology. 2 (11): 1097\u2013108. doi:10.1093\/intimm\/2.11.1097. PMID\u00a02083230.Erle DJ, Brown T, Christian D, Aris R (Mar 1994). “Lung epithelial lining fluid T cell subsets defined by distinct patterns of beta 7 and beta 1 integrin expression”. American Journal of Respiratory Cell and Molecular Biology. 10 (3): 237\u201344. doi:10.1165\/ajrcmb.10.3.7509610. PMID\u00a07509610.Postigo AA, S\u00e1nchez-Mateos P, Lazarovits AI, S\u00e1nchez-Madrid F, de Land\u00e1zuri MO (Sep 1993). “Alpha 4 beta 7 integrin mediates B cell binding to fibronectin and vascular cell adhesion molecule-1. Expression and function of alpha 4 integrins on human B lymphocytes”. Journal of Immunology. 151 (5): 2471\u201383. PMID\u00a07689608.Shaw SK, Cepek KL, Murphy EA, Russell GJ, Brenner MB, Parker CM (Feb 1994). “Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution”. The Journal of Biological Chemistry. 269 (8): 6016\u201325. doi:10.1016\/S0021-9258(17)37563-4. PMID\u00a08119947.Tidswell M, Pachynski R, Wu SW, Qiu SQ, Dunham E, Cochran N, Briskin MJ, Kilshaw PJ, Lazarovits AI, Andrew DP, Butcher EC, Yednock TA, Erle DJ (Aug 1997). “Structure-function analysis of the integrin beta 7 subunit: identification of domains involved in adhesion to MAdCAM-1”. Journal of Immunology. 159 (3): 1497\u2013505. PMID\u00a09233649.Tan K, Casasnovas JM, Liu JH, Briskin MJ, Springer TA, Wang JH (Jun 1998). “The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition”. Structure. 6 (6): 793\u2013801. doi:10.1016\/S0969-2126(98)00080-X. PMID\u00a09655832.Rietzler M, Bittner M, Kolanus W, Schuster A, Holzmann B (Oct 1998). “The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins”. The Journal of Biological Chemistry. 273 (42): 27459\u201366. doi:10.1074\/jbc.273.42.27459. PMID\u00a09765275.Taraszka KS, Higgins JM, Tan K, Mandelbrot DA, Wang JH, Brenner MB (May 2000). “Molecular basis for leukocyte integrin alpha(E)beta(7) adhesion to epithelial (E)-cadherin”. The Journal of Experimental Medicine. 191 (9): 1555\u201367. doi:10.1084\/jem.191.9.1555. PMC\u00a02213439. PMID\u00a010790430.Higgins JM, Cernadas M, Tan K, Irie A, Wang J, Takada Y, Brenner MB (Aug 2000). “The role of alpha and beta chains in ligand recognition by beta 7 integrins”. The Journal of Biological Chemistry. 275 (33): 25652\u201364. doi:10.1074\/jbc.M001228200. PMID\u00a010837471.Puig-Kr\u00f6ger A, Sanz-Rodr\u00edguez F, Longo N, S\u00e1nchez-Mateos P, Botella L, Teixid\u00f3 J, Bernab\u00e9u C, Corb\u00ed AL (Oct 2000). “Maturation-dependent expression and function of the CD49d integrin on monocyte-derived human dendritic cells”. Journal of Immunology. 165 (8): 4338\u201345. doi:10.4049\/jimmunol.165.8.4338. PMID\u00a011035069.Guilliano MJ, Foxx-Orenstein AE, Lebman DA (Feb 2001). “The microenvironment of human Peyer’s patches inhibits the increase in CD38 expression associated with the germinal center reaction”. Journal of Immunology. 166 (4): 2179\u201385. doi:10.4049\/jimmunol.166.4.2179. PMID\u00a011160270.Calderwood DA, Huttenlocher A, Kiosses WB, Rose DM, Woodside DG, Schwartz MA, Ginsberg MH (Dec 2001). “Increased filamin binding to beta-integrin cytoplasmic domains inhibits cell migration”. Nature Cell Biology. 3 (12): 1060\u20138. doi:10.1038\/ncb1201-1060. PMID\u00a011781567. S2CID\u00a06459957.Calderwood DA, Fujioka Y, de Pereda JM, Garc\u00eda-Alvarez B, Nakamoto T, Margolis B, McGlade CJ, Liddington RC, Ginsberg MH (Mar 2003). “Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling”. Proceedings of the National Academy of Sciences of the United States of America. 100 (5): 2272\u20137. Bibcode:2003PNAS..100.2272C. doi:10.1073\/pnas.262791999. PMC\u00a0151330. PMID\u00a012606711.External links[edit]PDB gallery       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x42brq: CRYSTAL STRUCTURE OF THE FILAMIN A REPEAT 21 COMPLEXED WITH THE INTEGRIN BETA7 CYTOPLASMIC TAIL PEPTIDE       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/integrin-beta-7-wikipedia\/#breadcrumbitem","name":"Integrin beta 7 – Wikipedia"}}]}]