[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/integrin-beta-8-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/integrin-beta-8-wikipedia\/","headline":"Integrin beta 8 – Wikipedia","name":"Integrin beta 8 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Integrin beta-8 is a protein that in humans","datePublished":"2022-10-08","dateModified":"2022-10-08","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/integrin-beta-8-wikipedia\/","wordCount":4375,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensIntegrin beta-8 is a protein that in humans is encoded by the ITGB8 gene.[5]Table of ContentsFunction[edit]Clinical significance[edit]References[edit]Further reading[edit]External links[edit]Function[edit]This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all the variants have been fully characterized.[5]  Additionally, it has been shown to interact with RhoGDI1 to alter the activation of Rho GTPases to promote Glioblastoma cell invasiveness.  Uncoupling the \u03b1v\u03b28-RhoGDI1 interaction has been seen to block GBM cell invasion by hyperactivating Rho GTPases.[6]Clinical significance[edit]High expression levels of ITGB8 are associated with high angiogenic and poorly invasive glioblastoma tumors.  Conversely low expression of ITGB8 correlates with highly invasive but low angiogenic tumors.[7]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000105855 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025321 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ a b “Entrez Gene: ITGB8 integrin, beta 8”.^ Reyes SB, Narayanan AS, Lee HS, Tchaicha JH, Aldape KD, Lang FF, Tolias KF, McCarty JH (January 2012). “\u03b1v\u03b28 Integrin Interacts with RhoGDI1 to Regulate Rac1 and Cdc42 Activation and Drive Glioblastoma Cell Invasion”. Mol Biol Cell. 24 (4): 474\u201382. doi:10.1091\/mbc.E12-07-0521. PMC\u00a03571870. PMID\u00a023283986.^ Tchaicha JH, Reyes SB, Shin J, Hossain MG, Lang FF, McCarty JH (October 2011). “Glioblastoma Angiogenesis and Tumor Cell Invasiveness Are Differentially Regulated by {beta}8 Integrin”. Cancer Res. 71 (20): 6371\u201381. doi:10.1158\/0008-5472.CAN-11-0991. PMC\u00a03193578. PMID\u00a021859829.Further reading[edit]Moyle M, Napier MA, McLean JW (1991). “Cloning and expression of a divergent integrin subunit beta 8”. J. Biol. Chem. 266 (29): 19650\u20138. doi:10.1016\/S0021-9258(18)55042-0. PMID\u00a01918072.Nishimura SL, Sheppard D, Pytela R (1994). “Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain”. J. Biol. Chem. 269 (46): 28708\u201315. doi:10.1016\/S0021-9258(19)61963-0. PMID\u00a07525578.Pilewski JM, Latoche JD, Arcasoy SM, Albelda SM (1997). “Expression of integrin cell adhesion receptors during human airway epithelial repair in vivo”. Am. J. Physiol. 273 (1 Pt 1): L256\u201363. doi:10.1152\/ajplung.1997.273.1.L256. PMID\u00a09252563.Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). “Toward a complete human genome sequence”. Genome Res. 8 (11): 1097\u2013108. doi:10.1101\/gr.8.11.1097. PMID\u00a09847074.Cambier S, Mu DZ, O’Connell D,  et\u00a0al. (2001). “A role for the integrin alphavbeta8 in the negative regulation of epithelial cell growth”. Cancer Res. 60 (24): 7084\u201393. PMID\u00a011156415.Mu D, Cambier S, Fjellbirkeland L,  et\u00a0al. (2002). “The integrin \u03b1v\u03b28 mediates epithelial homeostasis through MT1-MMP\u2013dependent activation of TGF-\u03b21”. J. Cell Biol. 157 (3): 493\u2013507. doi:10.1083\/jcb.200109100. PMC\u00a02173277. PMID\u00a011970960.Jarad G, Wang B, Khan S,  et\u00a0al. (2003). “Fas activation induces renal tubular epithelial cell beta 8 integrin expression and function in the absence of apoptosis”. J. Biol. Chem. 277 (49): 47826\u201333. doi:10.1074\/jbc.M204901200. PMID\u00a012324452.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Scherer SW, Cheung J, MacDonald JR,  et\u00a0al. (2003). “Human Chromosome 7: DNA Sequence and Biology”. Science. 300 (5620): 767\u201372. Bibcode:2003Sci…300..767S. doi:10.1126\/science.1083423. PMC\u00a02882961. PMID\u00a012690205.Hillier LW, Fulton RS, Fulton LA,  et\u00a0al. (2003). “The DNA sequence of human chromosome 7”. Nature. 424 (6945): 157\u201364. Bibcode:2003Natur.424..157H. doi:10.1038\/nature01782. PMID\u00a012853948.Fjellbirkeland L, Cambier S, Broaddus VC,  et\u00a0al. (2003). “Integrin \u03b1v\u03b28-Mediated Activation of Transforming Growth Factor-\u03b2 Inhibits Human Airway Epithelial Proliferation in Intact Bronchial Tissue”. Am. J. Pathol. 163 (2): 533\u201342. doi:10.1016\/S0002-9440(10)63681-4. PMC\u00a01868219. PMID\u00a012875973.Rual JF, Venkatesan K, Hao T,  et\u00a0al. (2005). “Towards a proteome-scale map of the human protein-protein interaction network”. Nature. 437 (7062): 1173\u20138. Bibcode:2005Natur.437.1173R. doi:10.1038\/nature04209. PMID\u00a016189514. S2CID\u00a04427026.Yan W, Shao R (2006). “Transduction of a mesenchyme-specific gene periostin into 293T cells induces cell invasive activity through epithelial-mesenchymal transformation”. J. Biol. Chem. 281 (28): 19700\u20138. doi:10.1074\/jbc.M601856200. PMID\u00a016702213.External links[edit]  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/integrin-beta-8-wikipedia\/#breadcrumbitem","name":"Integrin beta 8 – Wikipedia"}}]}]