[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/irak3-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/irak3-wikipedia\/","headline":"IRAK3 – Wikipedia","name":"IRAK3 – Wikipedia","description":"From Wikipedia, the free encyclopedia Interleukin-1 receptor-associated kinase 3 is an enzyme that in humans is encoded by the IRAK3","datePublished":"2022-05-28","dateModified":"2022-05-28","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/irak3-wikipedia\/","wordCount":3966,"articleBody":"From Wikipedia, the free encyclopediaInterleukin-1 receptor-associated kinase 3 is an enzyme that in humans is encoded by the IRAK3 gene.[5][6] Using in vivo liposome-mediated delivery of CRISPR\/Cas9 plasmid expressing IRAK3 gRNA, IRAK3 was shown to be responsible for endotoxin-induced expression of A20 and VE-cadherin in endothelial cells. Thus, IRAK3 is crucial for maintenance and repair of endothelial barrier after endotoxin-induced lung injury.[7]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000090376 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020227 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (July 1999). “IRAK-M is a novel member of the Pelle\/interleukin-1 receptor-associated kinase (IRAK) family”. The Journal of Biological Chemistry. 274 (27): 19403\u201310. doi:10.1074\/jbc.274.27.19403. PMID\u00a010383454.^ “Entrez Gene: IRAK3 interleukin-1 receptor-associated kinase 3”.^ Soni D, Wang DM, Regmi SC, Mittal M, Vogel SM, Schl\u00fcter D, Tiruppathi C (May 2018). “Deubiquitinase function of A20 maintains and repairs endothelial barrier after lung vascular injury”. Cell Death Discovery. 4 (60): 60. doi:10.1038\/s41420-018-0056-3. PMC\u00a05955943. PMID\u00a029796309.Further reading[edit]Rosati O, Martin MU (May 2002). “Identification and characterization of murine IRAK-M”. Biochemical and Biophysical Research Communications. 293 (5): 1472\u20137. doi:10.1016\/S0006-291X(02)00411-4. PMID\u00a012054681.Bin LH, Xu LG, Shu HB (July 2003). “TIRP, a novel Toll\/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling”. The Journal of Biological Chemistry. 278 (27): 24526\u201332. doi:10.1074\/jbc.M303451200. PMID\u00a012721283.Escoll P, del Fresno C, Garc\u00eda L, Vall\u00e9s G, Lend\u00ednez MJ, Arnalich F, L\u00f3pez-Collazo E (November 2003). “Rapid up-regulation of IRAK-M expression following a second endotoxin challenge in human monocytes and in monocytes isolated from septic patients”. Biochemical and Biophysical Research Communications. 311 (2): 465\u201372. doi:10.1016\/j.bbrc.2003.10.019. PMID\u00a014592437.del Fresno C, Otero K, G\u00f3mez-Garc\u00eda L, Gonz\u00e1lez-Le\u00f3n MC, Soler-Ranger L, Fuentes-Prior P, Escoll P, Baos R, Caveda L, Garc\u00eda F, Arnalich F, L\u00f3pez-Collazo E (March 2005). “Tumor cells deactivate human monocytes by up-regulating IL-1 receptor associated kinase-M expression via CD44 and TLR4”. Journal of Immunology. 174 (5): 3032\u201340. doi:10.4049\/jimmunol.174.5.3032. PMID\u00a015728517.Su J, Xie Q, Wilson I, Li L (July 2007). “Differential regulation and role of interleukin-1 receptor associated kinase-M in innate immunity signaling”. Cellular Signalling. 19 (7): 1596\u2013601. doi:10.1016\/j.cellsig.2007.02.009. PMC\u00a01978187. PMID\u00a017379480.Balaci L, Spada MC, Olla N, Sole G, Loddo L, Anedda F, Naitza S, Zuncheddu MA, Maschio A, Altea D, Uda M, Pilia S, Sanna S, Masala M, Crisponi L, Fattori M, Devoto M, Doratiotto S, Rassu S, Mereu S, Giua E, Cadeddu NG, Atzeni R, Pelosi U, Corrias A, Perra R, Torrazza PL, Pirina P, Ginesu F, Marcias S, Schintu MG, Del Giacco GS, Manconi PE, Malerba G, Bisognin A, Trabetti E, Boner A, Pescollderungg L, Pignatti PF, Schlessinger D, Cao A, Pilia G (June 2007). “IRAK-M is involved in the pathogenesis of early-onset persistent asthma”. American Journal of Human Genetics. 80 (6): 1103\u201314. doi:10.1086\/518259. PMC\u00a01867098. PMID\u00a017503328.Weersma RK, Oostenbrug LE, Nolte IM, Van Der Steege G, Oosterom E, Van Dullemen HM, Kleibeuker JH, Dijkstra G (July 2007). “Association of interleukin-1 receptor-associated kinase M (IRAK-M) and inflammatory bowel diseases”. Scandinavian Journal of Gastroenterology. 42 (7): 827\u201333. doi:10.1080\/00365520601114024. PMID\u00a017558906. S2CID\u00a022703718.van ‘t Veer C, van den Pangaart PS, van Zoelen MA, de Kruif M, Birjmohun RS, Stroes ES, de Vos AF, van der Poll T (November 2007). “Induction of IRAK-M is associated with lipopolysaccharide tolerance in a human endotoxemia model”. Journal of Immunology. 179 (10): 7110\u201320. doi:10.4049\/jimmunol.179.10.7110. PMID\u00a017982103.External links[edit]Overview of all the structural information available in the PDB for UniProt: Q9Y616 (Interleukin-1 receptor-associated kinase 3) at the PDBe-KB.ChemokineCSFInterferonIFNAR (\u03b1\/\u03b2, I)Agonists: AlbinterferonInterferon alpha (interferon alfa, IFN-\u03b1)Interferon alfa (IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21)Interferon alfa 2aInterferon alfa 2bInterferon alfa n1Interferon alfacon-1Interferon alpha-n3Interferon beta (IFN-\u03b2) (IFNB1, IFNB3)Interferon beta 1aInterferon beta 1bInterferon kappa (IFN-\u03b5\/\u03ba\/\u03c4\/\u03b6, IFNK)Interferon omega (IFN-\u03c9, IFNW1)Peginterferon alfa-2aPeginterferon alfa-2bIFNGR (\u03b3, II)IFNLR (\u03bb, III)See IL-28R (IFNLR) here instead.InterleukinTGF\u03b2TNFOthers  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/irak3-wikipedia\/#breadcrumbitem","name":"IRAK3 – Wikipedia"}}]}]