[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/kcnk1-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/kcnk1-wikipedia\/","headline":"KCNK1 – Wikipedia","name":"KCNK1 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Potassium channel subfamily K member 1 is a","datePublished":"2022-04-02","dateModified":"2022-04-02","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/kcnk1-wikipedia\/","about":["Wiki"],"wordCount":4579,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensPotassium channel subfamily K member 1 is a protein that in humans is encoded by the KCNK1 gene.[5][6][7]This gene encodes K2P1.1, a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, and it may require other non-pore-forming proteins for activity.[7]Table of ContentsSee also[edit]References[edit]Further reading[edit]External links[edit]See also[edit]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000135750 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033998 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Lesage F, Mattei M, Fink M, Barhanin J, Lazdunski M (Dec 1996). “Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to chromosome 1q42-q43”. Genomics. 34 (1): 153\u20135. doi:10.1006\/geno.1996.0259. PMID\u00a08661042.^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). “International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels”. Pharmacol Rev. 57 (4): 527\u201340. doi:10.1124\/pr.57.4.12. PMID\u00a016382106. S2CID\u00a07356601.^ a b “Entrez Gene: KCNK1 potassium channel, subfamily K, member 1”.Further reading[edit]Goldstein SA, Wang KW, Ilan N, Pausch MH (1998). “Sequence and function of the two P domain potassium channels: implications of an emerging superfamily”. J. Mol. Med. 76 (1): 13\u201320. doi:10.1007\/s109-1998-8100-0. PMID\u00a09462864.Lesage F, Lazdunski M (2000). “Molecular and functional properties of two-pore-domain potassium channels”. Am. J. Physiol. Renal Physiol. 279 (5): F793\u2013801. doi:10.1152\/ajprenal.2000.279.5.F793. PMID\u00a011053038. S2CID\u00a016605017.Goldstein SA, Bockenhauer D, O’Kelly I, Zilberberg N (2001). “Potassium leak channels and the KCNK family of two-P-domain subunits”. Nat. Rev. Neurosci. 2 (3): 175\u201384. doi:10.1038\/35058574. PMID\u00a011256078. S2CID\u00a09682396.Lesage F, Guillemare E, Fink M,  et\u00a0al. (1996). “TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure”. EMBO J. 15 (5): 1004\u201311. doi:10.1002\/j.1460-2075.1996.tb00437.x. PMC\u00a0449995. PMID\u00a08605869.Lesage F, Reyes R, Fink M,  et\u00a0al. (1997). “Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge”. EMBO J. 15 (23): 6400\u20137. doi:10.1002\/j.1460-2075.1996.tb01031.x. PMC\u00a0452465. PMID\u00a08978667.Orias M, Vel\u00e1zquez H, Tung F,  et\u00a0al. (1997). “Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments”. Am. J. Physiol. 273 (4 Pt 2): F663\u20136. doi:10.1152\/ajprenal.1997.273.4.F663. PMID\u00a09362344.Wang Z, Yue L, White M,  et\u00a0al. (1999). “Differential distribution of inward rectifier potassium channel transcripts in human atrium versus ventricle”. Circulation. 98 (22): 2422\u20138. doi:10.1161\/01.cir.98.22.2422. PMID\u00a09832487.Medhurst AD, Rennie G, Chapman CG,  et\u00a0al. (2001). “Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery”. Brain Res. Mol. Brain Res. 86 (1\u20132): 101\u201314. doi:10.1016\/S0169-328X(00)00263-1. PMID\u00a011165377.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Nicolas MT, Barhanin J, Reyes R, Dem\u00eames D (2004). “Cellular localization of TWIK-1, a two-pore-domain potassium channel in the rodent inner ear”. Hear. Res. 181 (1\u20132): 20\u20136. doi:10.1016\/S0378-5955(03)00162-X. PMID\u00a012855359. S2CID\u00a023605830.Ota T, Suzuki Y, Nishikawa T,  et\u00a0al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40\u20135. doi:10.1038\/ng1285. PMID\u00a014702039.Gerhard DS, Wagner L, Feingold EA,  et\u00a0al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121\u20137. doi:10.1101\/gr.2596504. PMC\u00a0528928. PMID\u00a015489334.Rajan S, Plant LD, Rabin ML,  et\u00a0al. (2005). “Sumoylation silences the plasma membrane leak K+ channel K2P1”. Cell. 121 (1): 37\u201347. doi:10.1016\/j.cell.2005.01.019. PMID\u00a015820677. S2CID\u00a06314155.Rual JF, Venkatesan K, Hao T,  et\u00a0al. (2005). “Towards a proteome-scale map of the human protein-protein interaction network”. Nature. 437 (7062): 1173\u20138. Bibcode:2005Natur.437.1173R. doi:10.1038\/nature04209. PMID\u00a016189514. S2CID\u00a04427026.External links[edit]This article incorporates text from the United States National Library of Medicine, which is in the public domain.  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/kcnk1-wikipedia\/#breadcrumbitem","name":"KCNK1 – Wikipedia"}}]}]