[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/klrc4-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/klrc4-wikipedia\/","headline":"KLRC4 – Wikipedia","name":"KLRC4 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 NKG2-F type II integral membrane protein is a protein that in humans is","datePublished":"2019-12-17","dateModified":"2019-12-17","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/klrc4-wikipedia\/","about":["Wiki"],"wordCount":4044,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4NKG2-F type II integral membrane protein is a protein that in humans is encoded by the KLRC4 gene.[3][4]Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC4 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. The 3′ end of the KLRC4 transcript includes the first non-coding exon found at the 5′ end of the adjacent D12S2489E gene transcript.[4]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4References[edit]Further reading[edit]Vivier E, Tomasello E, Paul P (2002). “Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition?”. Curr. Opin. Immunol. 14 (3): 306\u201311. doi:10.1016\/S0952-7915(02)00337-0. PMID\u00a011973127.Houchins JP, Yabe T, McSherry C, Bach FH (1991). “DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells”. J. Exp. Med. 173 (4): 1017\u201320. doi:10.1084\/jem.173.4.1017. PMC\u00a02190798. PMID\u00a02007850.Yabe T, McSherry C, Bach FH,  et\u00a0al. (1993). “A multigene family on human chromosome 12 encodes natural killer-cell lectins”. Immunogenetics. 37 (6): 455\u201360. doi:10.1007\/BF00222470. PMID\u00a08436421. S2CID\u00a027350036.Plougastel B, Trowsdale J (1998). “Cloning of NKG2-F, a new member of the NKG2 family of human natural killer cell receptor genes”. Eur. J. Immunol. 27 (11): 2835\u20139. doi:10.1002\/eji.1830271114. PMID\u00a09394807. S2CID\u00a07841240.Glienke J, Sobanov Y, Brostjan C,  et\u00a0al. (1998). “The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex”. Immunogenetics. 48 (3): 163\u201373. doi:10.1007\/s002510050420. PMID\u00a09683661. S2CID\u00a022585415.Bauer S, Groh V, Wu J,  et\u00a0al. (1999). “Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA”. Science. 285 (5428): 727\u20139. doi:10.1126\/science.285.5428.727. PMID\u00a010426993.Wu J, Song Y, Bakker AB,  et\u00a0al. (1999). “An activating immunoreceptor complex formed by NKG2D and DAP10”. Science. 285 (5428): 730\u20132. doi:10.1126\/science.285.5428.730. PMID\u00a010426994.Li P, Morris DL, Willcox BE,  et\u00a0al. (2001). “Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA”. Nat. Immunol. 2 (5): 443\u201351. doi:10.1038\/87757. PMID\u00a011323699. S2CID\u00a011096566.O’Callaghan CA, Cerwenka A, Willcox BE,  et\u00a0al. (2001). “Molecular competition for NKG2D: H60 and RAE1 compete unequally for NKG2D with dominance of H60”. Immunity. 15 (2): 201\u201311. doi:10.1016\/S1074-7613(01)00187-X. PMID\u00a011520456.Girardi M, Oppenheim DE, Steele CR,  et\u00a0al. (2001). “Regulation of cutaneous malignancy by gammadelta T cells”. Science. 294 (5542): 605\u20139. Bibcode:2001Sci…294..605G. doi:10.1126\/science.1063916. PMID\u00a011567106. S2CID\u00a083809313.Shum BP, Flodin LR, Muir DG,  et\u00a0al. (2002). “Conservation and variation in human and common chimpanzee CD94 and NKG2 genes”. J. Immunol. 168 (1): 240\u201352. doi:10.4049\/jimmunol.168.1.240. PMID\u00a011751968.Radaev S, Rostro B, Brooks AG,  et\u00a0al. (2002). “Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3”. Immunity. 15 (6): 1039\u201349. doi:10.1016\/S1074-7613(01)00241-2. PMID\u00a011754823.Sutherland CL, Chalupny NJ, Schooley K,  et\u00a0al. (2002). “UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells”. J. Immunol. 168 (2): 671\u20139. doi:10.4049\/jimmunol.168.2.671. PMID\u00a011777960.Holmes MA, Li P, Petersdorf EW, Strong RK (2002). “Structural studies of allelic diversity of the MHC class I homolog MIC-B, a stress-inducible ligand for the activating immunoreceptor NKG2D”. J. Immunol. 169 (3): 1395\u2013400. doi:10.4049\/jimmunol.169.3.1395. PMID\u00a012133964.Gilfillan S, Ho EL, Cella M,  et\u00a0al. (2002). “NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation”. Nat. Immunol. 3 (12): 1150\u20135. doi:10.1038\/ni857. PMID\u00a012426564. S2CID\u00a05859797.Diefenbach A, Tomasello E, Lucas M,  et\u00a0al. (2002). “Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D”. Nat. Immunol. 3 (12): 1142\u20139. doi:10.1038\/ni858. PMID\u00a012426565. S2CID\u00a014901451.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.McFarland BJ, Kortemme T, Yu SF,  et\u00a0al. (2004). “Symmetry recognizing asymmetry: analysis of the interactions between the C-type lectin-like immunoreceptor NKG2D and MHC class I-like ligands”. Structure. 11 (4): 411\u201322. doi:10.1016\/S0969-2126(03)00047-9. PMID\u00a012679019.       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/klrc4-wikipedia\/#breadcrumbitem","name":"KLRC4 – Wikipedia"}}]}]