[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/latrophilin-3-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/latrophilin-3-wikipedia\/","headline":"Latrophilin 3 &#8211; Wikipedia","name":"Latrophilin 3 &#8211; Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Latrophilin 3 is a protein that","datePublished":"2021-04-01","dateModified":"2021-04-01","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/latrophilin-3-wikipedia\/","about":["Wiki"],"wordCount":3293,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensLatrophilin 3 is a protein that in humans is encoded by the ADGRL3 gene.[5][6]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Table of ContentsFunction[edit]Clinical significance[edit]See also[edit]References[edit]Further reading[edit]External links[edit]Function[edit]This gene encodes a member of the latrophilin subfamily of G protein-coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin\/calcitonin family of GPCRs) being non-covalently bound at the cell membrane.[6]Clinical significance[edit]A version of this gene has been linked to attention deficit hyperactivity disorder (ADHD).[7]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4See also[edit]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000150471 &#8211; Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037605 &#8211; Ensembl, May 2017^ &#8220;Human PubMed Reference:&#8221;. National Center for Biotechnology Information, U.S. National Library of Medicine.^ &#8220;Mouse PubMed Reference:&#8221;. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Hayflick JS (Jan 2001). &#8220;A family of heptahelical receptors with adhesion-like domains: a marriage between two super families&#8221;. Journal of Receptor and Signal Transduction Research. 20 (2\u20133): 119\u201331. doi:10.3109\/10799890009150640. PMID\u00a010994649. S2CID\u00a019919738.^ a b &#8220;Entrez Gene: LPHN3 latrophilin 3&#8221;.^ Arcos-Burgos M, Jain M, Acosta MT, Shively S, Stanescu H, Wallis D,  et\u00a0al. (Nov 2010). &#8220;A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts the effectiveness of stimulant medication&#8221;. Molecular Psychiatry. 15 (11): 1053\u201366. doi:10.1038\/mp.2010.6. PMID\u00a020157310.Further reading[edit]S\u00fcdhof TC (2001). &#8220;alpha-Latrotoxin and its receptors: neurexins and CIRL\/latrophilins&#8221;. Annual Review of Neuroscience. 24: 933\u201362. doi:10.1146\/annurev.neuro.24.1.933. PMID\u00a011520923.Ushkaryov YA, Volynski KE, Ashton AC (Apr 2004). &#8220;The multiple actions of black widow spider toxins and their selective use in neurosecretion studies&#8221;. Toxicon. 43 (5): 527\u201342. doi:10.1016\/j.toxicon.2004.02.008. PMID\u00a015066411.Soares MB, Bonaldo MF, Jelene P, Su L, Lawton L, Efstratiadis A (Sep 1994). &#8220;Construction and characterization of a normalized cDNA library&#8221;. Proceedings of the National Academy of Sciences of the United States of America. 91 (20): 9228\u201332. Bibcode:1994PNAS&#8230;91.9228S. doi:10.1073\/pnas.91.20.9228. PMC\u00a044785. PMID\u00a07937745.Sanger Centre, The; Washington University Genome Sequencing Cente, The (Nov 1998). &#8220;Toward a complete human genome sequence&#8221;. Genome Research. 8 (11): 1097\u2013108. doi:10.1101\/gr.8.11.1097. PMID\u00a09847074.Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998). &#8220;Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro&#8221;. DNA Research. 5 (5): 277\u201386. doi:10.1093\/dnares\/5.5.277. PMID\u00a09872452.Kreienkamp HJ, Zitzer H, Gundelfinger ED, Richter D, Bockers TM (Oct 2000). &#8220;The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP\/SSTRIP\/Shank family of multidomain proteins&#8221;. The Journal of Biological Chemistry. 275 (42): 32387\u201390. doi:10.1074\/jbc.C000490200. PMID\u00a010964907.Bjarnad\u00f3ttir TK, Fredriksson R, H\u00f6glund PJ, Gloriam DE, Lagerstr\u00f6m MC, Schi\u00f6th HB (Jul 2004). &#8220;The human and mouse repertoire of the adhesion family of G-protein-coupled receptors&#8221;. Genomics. 84 (1): 23\u201333. doi:10.1016\/j.ygeno.2003.12.004. PMID\u00a015203201.External links[edit]PDBe-KB provides an overview of all the structure information available in the PDB for Human Adhesion G protein-coupled receptor L3PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Adhesion G protein-coupled receptor L3This article incorporates text from the United States National Library of Medicine, which is in the public domain.       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/latrophilin-3-wikipedia\/#breadcrumbitem","name":"Latrophilin 3 &#8211; Wikipedia"}}]}]