[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/lmo1-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/lmo1-wikipedia\/","headline":"LMO1 – Wikipedia","name":"LMO1 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Rhombotin-1 is a protein that in","datePublished":"2017-06-23","dateModified":"2017-06-23","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/lmo1-wikipedia\/","wordCount":6762,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensRhombotin-1 is a protein that in humans is encoded by the LMO1 gene.[5][6][7]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4LMO1 encodes a cysteine-rich, two LIM domain transcriptional regulator. It is mapped to an area of consistent chromosomal translocation in chromosome 11, disrupting it in T-cell leukemia, although more rarely than the related gene, LMO2 is disrupted.[7]Interactions[edit]LMO1 has been shown to interact with GATA3[8][9] and TAL1.[10][11]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000166407 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036111 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Boehm T, Foroni L, Kaneko Y, Perutz MF, Rabbitts TH (June 1991). “The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13”. Proc Natl Acad Sci U S A. 88 (10): 4367\u201371. Bibcode:1991PNAS…88.4367B. doi:10.1073\/pnas.88.10.4367. PMC\u00a051660. PMID\u00a02034676.^ McGuire EA, Davis AR, Korsmeyer SJ (March 1991). “T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells”. Blood. 77 (3): 599\u2013606. doi:10.1182\/blood.V77.3.599.599. PMID\u00a01703797.^ a b “Entrez Gene: LMO1 LIM domain only 1 (rhombotin 1)”.^ Ono, Y; Fukuhara N; Yoshie O (December 1998). “TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3”. Mol. Cell. Biol. 18 (12): 6939\u201350. doi:10.1128\/MCB.18.12.6939. ISSN\u00a00270-7306. PMC\u00a0109277. PMID\u00a09819382.^ Ono, Y; Fukuhara N; Yoshie O (February 1997). “Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL”. J. Biol. Chem. 272 (7): 4576\u201381. doi:10.1074\/jbc.272.7.4576. ISSN\u00a00021-9258. PMID\u00a09020185.^ Valge-Archer, V E; Osada H; Warren A J; Forster A; Li J; Baer R; Rabbitts T H (August 1994). “The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells”. Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617\u201321. Bibcode:1994PNAS…91.8617V. doi:10.1073\/pnas.91.18.8617. ISSN\u00a00027-8424. PMC\u00a044657. PMID\u00a08078932.^ Wadman, I; Li J; Bash R O; Forster A; Osada H; Rabbitts T H; Baer R (October 1994). “Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia”. EMBO J. 13 (20): 4831\u20139. doi:10.1002\/j.1460-2075.1994.tb06809.x. ISSN\u00a00261-4189. PMC\u00a0395422. PMID\u00a07957052.Further reading[edit]Foroni L, Boehm T, White L,  et\u00a0al. (1992). “The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development”. J. Mol. Biol. 226 (3): 747\u201361. doi:10.1016\/0022-2836(92)90630-3. PMID\u00a01507224.Boehm T, Spillantini MG, Sofroniew MV,  et\u00a0al. (1991). “Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: evidence for thymus expression”. Oncogene. 6 (5): 695\u2013703. PMID\u00a02052354.Chen Q, Cheng JT, Tasi LH,  et\u00a0al. (1990). “The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein”. EMBO J. 9 (2): 415\u201324. doi:10.1002\/j.1460-2075.1990.tb08126.x. PMC\u00a0551682. PMID\u00a02303035.Boehm T, Greenberg JM, Buluwela L,  et\u00a0al. (1990). “An unusual structure of a putative T cell oncogene which allows production of similar proteins from distinct mRNAs”. EMBO J. 9 (3): 857\u201368. doi:10.1002\/j.1460-2075.1990.tb08183.x. PMC\u00a0551746. PMID\u00a02311586.McGuire EA, Hockett RD, Pollock KM,  et\u00a0al. (1989). “The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein”. Mol. Cell. Biol. 9 (5): 2124\u201332. doi:10.1128\/MCB.9.5.2124. PMC\u00a0363006. PMID\u00a02501659.Boehm T, Baer R, Lavenir I,  et\u00a0al. (1988). “The mechanism of chromosomal translocation t(11;14) involving the T-cell receptor C delta locus on human chromosome 14q11 and a transcribed region of chromosome 11p15”. EMBO J. 7 (2): 385\u201394. doi:10.1002\/j.1460-2075.1988.tb02825.x. PMC\u00a0454331. PMID\u00a03259177.Wadman I, Li J, Bash RO,  et\u00a0al. (1994). “Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia”. EMBO J. 13 (20): 4831\u20139. doi:10.1002\/j.1460-2075.1994.tb06809.x. PMC\u00a0395422. PMID\u00a07957052.Valge-Archer VE, Osada H, Warren AJ,  et\u00a0al. (1994). “The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells”. Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617\u201321. Bibcode:1994PNAS…91.8617V. doi:10.1073\/pnas.91.18.8617. PMC\u00a044657. PMID\u00a08078932.Arber S, Caroni P (1996). “Specificity of single LIM motifs in targeting and LIM\/LIM interactions in situ”. Genes Dev. 10 (3): 289\u2013300. doi:10.1101\/gad.10.3.289. PMID\u00a08595880.Jurata LW, Kenny DA, Gill GN (1996). “Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development”. Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11693\u20138. Bibcode:1996PNAS…9311693J. doi:10.1073\/pnas.93.21.11693. PMC\u00a038120. PMID\u00a08876198.Ono Y, Fukuhara N, Yoshie O (1997). “Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL”. J. Biol. Chem. 272 (7): 4576\u201381. doi:10.1074\/jbc.272.7.4576. PMID\u00a09020185.Valge-Archer V, Forster A, Rabbitts TH (1999). “The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11)”. Oncogene. 17 (24): 3199\u2013202. doi:10.1038\/sj.onc.1202353. PMID\u00a09872335.Bao J, Talmage DA, Role LW, Gautier J (2000). “Regulation of neurogenesis by interactions between HEN1 and neuronal LMO proteins”. Development. 127 (2): 425\u201335. doi:10.1242\/dev.127.2.425. PMID\u00a010603358.Cichutek A, Brueckmann T, Seipel B,  et\u00a0al. (2001). “Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1)”. Cytogenet. Cell Genet. 93 (3\u20134): 277\u201383. doi:10.1159\/000056998. PMID\u00a011528126. S2CID\u00a025807985.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Gerhard DS, Wagner L, Feingold EA,  et\u00a0al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121\u20137. doi:10.1101\/gr.2596504. PMC\u00a0528928. PMID\u00a015489334.Lin YW, Deveney R, Barbara M,  et\u00a0al. (2005). “OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1”. Cancer Res. 65 (16): 7151\u20138. doi:10.1158\/0008-5472.CAN-05-1400. PMC\u00a01681523. PMID\u00a016103065.Saeki N, Kim DH, Usui T,  et\u00a0al. (2007). “GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling”. Oncogene. 26 (45): 6488\u201398. doi:10.1038\/sj.onc.1210475. 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