[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/low-density-lipoprotein-receptor-related-protein-4\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/low-density-lipoprotein-receptor-related-protein-4\/","headline":"Low-density lipoprotein receptor-related protein 4","name":"Low-density lipoprotein receptor-related protein 4","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Low-density lipoprotein receptor-related protein 4 (LRP-4),","datePublished":"2022-11-13","dateModified":"2022-11-13","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/low-density-lipoprotein-receptor-related-protein-4\/","about":["Wiki"],"wordCount":3135,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensLow-density lipoprotein receptor-related protein 4 (LRP-4), also known as multiple epidermal growth factor-like domains 7 (MEGF7), is a protein that in humans is encoded by the LRP4 gene.[5][6] LRP-4 is a member of the Lipoprotein receptor-related protein family and may be a regulator of Wnt signaling.       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Clinical significance[edit]Mutations in this gene are associated with Cenani Lenz syndactylism.[7]Autoantibodies against LRP4 have been connected to a small fraction of myasthenia gravis cases.References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000134569 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027253 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Entrez Gene: low density lipoprotein receptor-related protein 4”.^ Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O (Jul 1998). “Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening”. Genomics. 51 (1): 27\u201334. doi:10.1006\/geno.1998.5341. PMID\u00a09693030.^ Li Y, Pawlik B, Elcioglu N, Aglan M, Kayserili H, Yigit G, Percin F, Goodman F, N\u00fcrnberg G, Cenani A, Urquhart J, Chung BD, Ismail S, Amr K, Aslanger AD, Becker C, Netzer C, Scambler P, Eyaid W, Hamamy H, Clayton-Smith J, Hennekam R, N\u00fcrnberg P, Herz J, Temtamy SA, Wollnik B (May 2010). “LRP4 mutations alter Wnt\/beta-catenin signaling and cause limb and kidney malformations in Cenani-Lenz syndrome”. American Journal of Human Genetics. 86 (5): 696\u2013706. doi:10.1016\/j.ajhg.2010.03.004. PMC\u00a02869043. PMID\u00a020381006.Further reading[edit]Nakayama M, Kikuno R, Ohara O (Nov 2002). “Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs”. Genome Research. 12 (11): 1773\u201384. doi:10.1101\/gr.406902. PMC\u00a0187542. PMID\u00a012421765.Jeong YH, Ishikawa K, Someya Y, Hosoda A, Yoshimi T, Yokoyama C, Kiryu-Seo S, Kang MJ, Tchibana T, Kiyama H, Fukumura T, Kim DH, Saeki S (Jan 2010). “Molecular characterization and expression of the low-density lipoprotein receptor-related protein-10, a new member of the LDLR gene family”. Biochemical and Biophysical Research Communications. 391 (1): 1110\u20135. doi:10.1016\/j.bbrc.2009.12.033. PMID\u00a020005200.Simon-Chazottes D, Tutois S, Kuehn M, Evans M, Bourgade F, Cook S, Davisson MT, Gu\u00e9net JL (May 2006). “Mutations in the gene encoding the low-density lipoprotein receptor LRP4 cause abnormal limb development in the mouse”. Genomics. 87 (5): 673\u20137. doi:10.1016\/j.ygeno.2006.01.007. PMID\u00a016517118.Li Y, Pawlik B, Elcioglu N, Aglan M, Kayserili H, Yigit G, Percin F, Goodman F, N\u00fcrnberg G, Cenani A, Urquhart J, Chung BD, Ismail S, Amr K, Aslanger AD, Becker C, Netzer C, Scambler P, Eyaid W, Hamamy H, Clayton-Smith J, Hennekam R, N\u00fcrnberg P, Herz J, Temtamy SA, Wollnik B (May 2010). “LRP4 mutations alter Wnt\/beta-catenin signaling and cause limb and kidney malformations in Cenani-Lenz syndrome”. American Journal of Human Genetics. 86 (5): 696\u2013706. doi:10.1016\/j.ajhg.2010.03.004. PMC\u00a02869043. PMID\u00a020381006.Liu JM, Zhang MJ, Zhao L, Cui B, Li ZB, Zhao HY, Sun LH, Tao B, Li M, Ning G (Sep 2010). “Analysis of recently identified osteoporosis susceptibility genes in Han Chinese women”. The Journal of Clinical Endocrinology and Metabolism. 95 (9): E112-20. doi:10.1210\/jc.2009-2768. PMID\u00a020554715.       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