[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/lrg1-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/lrg1-wikipedia\/","headline":"LRG1 – Wikipedia","name":"LRG1 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Leucine-rich alpha-2-glycoprotein 1 is a protein","datePublished":"2017-07-05","dateModified":"2017-07-05","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/lrg1-wikipedia\/","about":["Wiki"],"wordCount":5474,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensLeucine-rich alpha-2-glycoprotein 1 is a protein which in humans is encoded by the  gene LRG1.[5]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Table of ContentsFunction[edit]Application[edit]References[edit]Further reading[edit]Function[edit]The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation.[5][6]LRG1 has been shown to be involved in promoting neovascularization (new blood vessel growth) through causing a switch in transforming growth factor beta (TGFbeta) signaling in endothelial cells. LRG1 binds to the accessory receptor endoglin and promotes signaling via the ALK1-Smad1\/5\/8 pathway.[7]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Application[edit]Levels of the LRG protein are markedly elevated in acute appendicitis and therefore could be used as a diagnostic aid.[8]LRG1 may be a potential therapeutic target for the treatment of diseases where there is aberrant neovascularization.[7]Circulating LRG1 levels are increased in many cancer patients and may be a useful biomarker. Inhibition of LRG1 normalises the tumor vasculature, improves the efficacy of cytotoxic and immune therapies,[9] and restricts metastatic spread. [10]LRG1 has been implicated in the pathogenesis of numerous diseases including cancer, eye disease, neurodegenerative disease, diabetes, lung and kidney disease[11]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000171236 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037095 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ a b “Entrez Gene: LRG1 leucine-rich alpha-2-glycoprotein 1”.^ O’Donnell LC, Druhan LJ, Avalos BR (September 2002). “Molecular characterization and expression analysis of leucine-rich alpha2-glycoprotein, a novel marker of granulocytic differentiation”. Journal of Leukocyte Biology. 72 (3): 478\u2013485. doi:10.1189\/jlb.72.3.478. PMID\u00a012223515. S2CID\u00a0967662.^ a b Wang X, Abraham S, McKenzie JA, Jeffs N, Swire M, Tripathi VB,  et\u00a0al. (July 2013). “LRG1 promotes angiogenesis by modulating endothelial TGF-\u03b2 signalling”. Nature. 499 (7458): 306\u2013311. Bibcode:2013Natur.499..306W. doi:10.1038\/nature12345. PMC\u00a03836402. PMID\u00a023868260.^ Vargas IM (2009-06-23). “A urine test for appendicitis?”. HarvardScience Press Release. Harvard College. Retrieved 2009-06-25.^ O’Connor MN, Kallenberg DM, Camilli C, Pilotti C, Dritsoula A, Jackstadt R,  et\u00a0al. (November 2021). “LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency”. Med. 2 (11): 1231\u20131252.e10. doi:10.1016\/j.medj.2021.10.002. PMID\u00a035590198.^ Singhal M, Gengenbacher N, Abdul Pari AA, Kamiyama M, Hai L, Kuhn BJ,  et\u00a0al. (September 2021). “Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis”. Science Translational Medicine. 13 (609): eabe6805. doi:10.1126\/scitranslmed.abe6805. PMID\u00a034516824. S2CID\u00a0237402143.^ Camilli C, Hoeh AE, De Rossi G, Moss SE, Greenwood J (January 2022). “LRG1: an emerging player in disease pathogenesis”. Journal of Biomedical Science. 29 (1): 6. doi:10.1186\/s12929-022-00790-6. PMC\u00a08781713. PMID\u00a035062948.Further reading[edit]Li X, Miyajima M, Jiang C, Arai H (February 2007). “Expression of TGF-betas and TGF-beta type II receptor in cerebrospinal fluid of patients with idiopathic normal pressure hydrocephalus”. Neuroscience Letters. 413 (2): 141\u2013144. doi:10.1016\/j.neulet.2006.11.039. PMID\u00a017194537. S2CID\u00a054324280.Ramachandran P, Boontheung P, Xie Y, Sondej M, Wong DT, Loo JA (June 2006). “Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry”. Journal of Proteome Research. 5 (6): 1493\u20131503. doi:10.1021\/pr050492k. PMID\u00a016740002.Cummings C, Walder J, Treeful A, Jemmerson R (July 2006). “Serum leucine-rich alpha-2-glycoprotein-1 binds cytochrome c and inhibits antibody detection of this apoptotic marker in enzyme-linked immunosorbent assay”. Apoptosis. 11 (7): 1121\u20131129. doi:10.1007\/s10495-006-8159-3. PMID\u00a016699948. S2CID\u00a039838086.Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). “Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry”. Journal of Proteome Research. 4 (6): 2070\u20132080. doi:10.1021\/pr0502065. PMC\u00a01850943. PMID\u00a016335952.Yamada S, Ohira M, Horie H, Ando K, Takayasu H, Suzuki Y,  et\u00a0al. (August 2004). “Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas”. Oncogene. 23 (35): 5901\u20135911. doi:10.1038\/sj.onc.1207782. PMID\u00a015221005.Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wi\u015bniewski JR (February 2004). “Screening for N-glycosylated proteins by liquid chromatography mass spectrometry”. Proteomics. 4 (2): 454\u2013465. doi:10.1002\/pmic.200300556. PMID\u00a014760718. S2CID\u00a029261009.Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP,  et\u00a0al. (April 2004). “The human plasma proteome: a nonredundant list developed by combination of four separate sources”. Molecular & Cellular Proteomics. 3 (4): 311\u2013326. doi:10.1074\/mcp.M300127-MCP200. PMID\u00a014718574.O’Donnell LC, Druhan LJ, Avalos BR (September 2002). “Molecular characterization and expression analysis of leucine-rich alpha2-glycoprotein, a novel marker of granulocytic differentiation”. Journal of Leukocyte Biology. 72 (3): 478\u2013485. doi:10.1189\/jlb.72.3.478. PMID\u00a012223515. S2CID\u00a0967662.Saito K, Tanaka T, Kanda H, Ebisuno Y, Izawa D, Kawamoto S,  et\u00a0al. (February 2002). “Gene expression profiling of mucosal addressin cell adhesion molecule-1+ high endothelial venule cells (HEV) and identification of a leucine-rich HEV glycoprotein as a HEV marker”. Journal of Immunology. 168 (3): 1050\u20131059. doi:10.4049\/jimmunol.168.3.1050. PMID\u00a011801638.Takahashi N, Takahashi Y, Putnam FW (April 1985). “Periodicity of leucine and tandem repetition of a 24-amino acid segment in the primary structure of leucine-rich alpha 2-glycoprotein of human serum”. Proceedings of the National Academy of Sciences of the United States of America. 82 (7): 1906\u20131910. Bibcode:1985PNAS…82.1906T. doi:10.1073\/pnas.82.7.1906. PMC\u00a0397442. PMID\u00a03856868.Andersen JD, Boylan KL, Xue FS, Anderson LB, Witthuhn BA, Markowski TW,  et\u00a0al. (January 2010). “Identification of candidate biomarkers in ovarian cancer serum by depletion of highly abundant proteins and differential in-gel electrophoresis”. Electrophoresis. 31 (4): 599\u2013610. doi:10.1002\/elps.200900441. PMC\u00a03520508. PMID\u00a020162585.This article incorporates text from the United States National Library of Medicine, which is in the public domain.       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/lrg1-wikipedia\/#breadcrumbitem","name":"LRG1 – Wikipedia"}}]}]