[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/lrrc7-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/lrrc7-wikipedia\/","headline":"LRRC7 &#8211; Wikipedia","name":"LRRC7 &#8211; Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Leucine rich repeat containing 7 also","datePublished":"2021-11-17","dateModified":"2021-11-17","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/lrrc7-wikipedia\/","about":["Wiki"],"wordCount":3705,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensLeucine rich repeat containing 7 also known as LRRC7,  Densin-180, or LAP1 is a protein which in humans is encoded by the LRRC7 gene.[5]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Table of ContentsStructure[edit]Interactions[edit]References[edit]Further reading[edit]Structure[edit]Found to be densely associated to the postsynaptic density (PSD), it has been characterised as a 188 kDa (originally thought to be 180 kDa, hence nomenclature), 1495 residues long, brain-specific protein containing 16 leucine-rich repeats (LRRs) within the 500 N-terminal residues, and one Psd95\/Discs large\/Zona occludens (PDZ) domain within the 200 C-terminal residues. Originally postulated to have an apparent transmembrane domain, it has now been shown that the protein has numerous phosphorylation sites both N- and C-term of this domain, and that protein is therefore cytoplasmic; palmitoylation is thought to occur near the N-terminus of the protein which would account for localisation of the protein at the PSD.[6]Interactions[edit]LRRC7 has been shown to interact with CDH2.[7]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4The currently exposed interactions of Densin-180 portray the protein as a promiscuous player amongst key synaptic players, fitting with the original observation of the protein\u2019s dense presence among core PSD proteins by Mary B. Kennedy&#8217;s Laboratory. Identified interaction partners include: CaMKII-alpha, alpha-Actinin and NR2B (via CaMKII-alpha), Cav1.3 (L-type Ca2+) channels, MAGUIN-1, Shank, PSD-95 (via Shank and MAGUIN-1), beta-Catenin, delta-Catenins and NCadherin (via the Catenins). The nature and function of these interactions, detailed in tables 1-1 and 1-2, portray Densin-180 as a key interactor in the midst of receptor proteins, scaffolding proteins and structural proteins. [number of sources &#8211; referenced in &#8211; Subcellular localisation of recombinant Densin-180 clones expressed in HEK293 TSA cells Ranatunga, J.M. (2011) Subcellular localisation of recombinant Densin-180 clones expressed in HEK293 TSA cells. Masters thesis, UCL (University College London). http:\/\/discovery.ucl.ac.uk\/1322972\/]It is also quite possible that Densin-180 dimerises or multimerises through interactions between its PDZ domain and its own terminal amino acid residues. [Subcellular localisation of recombinant Densin-180 clones expressed in HEK293 TSA cellsRanatunga, J.M. (2011) Subcellular localisation of recombinant Densin-180 clones expressed in HEK293 TSA cells. Masters thesis, UCL (University College London). http:\/\/discovery.ucl.ac.uk\/1322972\/]References[edit]Further reading[edit]Apperson ML, Moon IS, Kennedy MB (1996). &#8220;Characterization of densin-180, a new brain-specific synaptic protein of the O-sialoglycoprotein family&#8221;. J. Neurosci. 16 (21): 6839\u201352. doi:10.1523\/JNEUROSCI.16-21-06839.1996. PMC\u00a06579252. PMID\u00a08824323.Nagase T, Kikuno R, Ishikawa KI,  et\u00a0al. (2000). &#8220;Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro&#8221;. DNA Res. 7 (1): 65\u201373. doi:10.1093\/dnares\/7.1.65. PMID\u00a010718198.Walikonis RS, Oguni A, Khorosheva EM,  et\u00a0al. (2001). &#8220;Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+\/calmodulin-dependent protein kinase II and (alpha)-actinin&#8221;. J. Neurosci. 21 (2): 423\u201333. doi:10.1523\/JNEUROSCI.21-02-00423.2001. PMC\u00a06763799. PMID\u00a011160423.Izawa I, Nishizawa M, Ohtakara K, Inagaki M (2002). &#8220;Densin-180 interacts with delta-catenin\/neural plakophilin-related armadillo repeat protein at synapses&#8221;. J. Biol. Chem. 277 (7): 5345\u201350. doi:10.1074\/jbc.M110052200. PMID\u00a011729199.Ohtakara K, Nishizawa M, Izawa I,  et\u00a0al. (2003). &#8220;Densin-180, a synaptic protein, links to PSD-95 through its direct interaction with MAGUIN-1&#8221;. Genes Cells. 7 (11): 1149\u201360. doi:10.1046\/j.1365-2443.2002.00589.x. PMID\u00a012390249.Wang L, Xu J, Wu Q,  et\u00a0al. (2003). &#8220;Cloning and characterization of a novel splice variant of the brain-specific protein densin-180&#8221;. Int. J. Mol. Med. 11 (2): 257\u201360. doi:10.3892\/ijmm.11.2.257. PMID\u00a012525888.Ahola H, Heikkil\u00e4 E, Astr\u00f6m E,  et\u00a0al. (2003). &#8220;A novel protein, densin, expressed by glomerular podocytes&#8221;. J. Am. Soc. Nephrol. 14 (7): 1731\u20137. doi:10.1097\/01.ASN.0000075553.33781.9F. PMID\u00a012819232.Goodchild RE, Dauer WT (2005). &#8220;The AAA+ protein torsinA interacts with a conserved domain present in LAP1 and a novel ER protein&#8221;. J. Cell Biol. 168 (6): 855\u201362. doi:10.1083\/jcb.200411026. PMC\u00a02171781. PMID\u00a015767459.Robison AJ, Bass MA, Jiao Y,  et\u00a0al. (2005). &#8220;Multivalent interactions of calcium\/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2&#8221;. J. Biol. Chem. 280 (42): 35329\u201336. doi:10.1074\/jbc.M502191200. PMID\u00a016120608.Gregory SG, Barlow KF, McLay KE,  et\u00a0al. (2006). &#8220;The DNA sequence and biological annotation of human chromosome 1&#8221;. Nature. 441 (7091): 315\u201321. Bibcode:2006Natur.441..315G. doi:10.1038\/nature04727. PMID\u00a016710414.Rinta-Valkama J, Aaltonen P, Lassila M,  et\u00a0al. (2007). &#8220;Densin and filtrin in the pancreas and in the kidney, targets for humoral autoimmunity in patients with type 1 diabetes&#8221;. Diabetes Metab. Res. Rev. 23 (2): 119\u201326. doi:10.1002\/dmrr.655. PMID\u00a016741999. S2CID\u00a030494486.Lassila M, Juhila J, Heikkil\u00e4 E, Holth\u00f6fer H (2007). &#8220;Densin is a novel cell membrane protein of Sertoli cells in the testis&#8221;. Mol. Reprod. Dev. 74 (5): 641\u20135. doi:10.1002\/mrd.20659. PMID\u00a017039495. S2CID\u00a043409823.Ewing RM, Chu P, Elisma F,  et\u00a0al. (2007). &#8220;Large-scale mapping of human protein-protein interactions by mass spectrometry&#8221;. Mol. Syst. Biol. 3 (1): 89. doi:10.1038\/msb4100134. PMC\u00a01847948. PMID\u00a017353931.Heikkil\u00e4 E, Ristola M, Endlich K,  et\u00a0al. (2007). &#8220;Densin and beta-catenin form a complex and co-localize in cultured podocyte cell junctions&#8221;. Mol. Cell. Biochem. 305 (1\u20132): 9\u201318. doi:10.1007\/s11010-007-9522-6. PMID\u00a017581699. S2CID\u00a031301047.Add\u2014a very detailed thesis with preliminary experiments and theories about the function of Densin-180 entitled Subcellular localisation of recombinant Densin-180 clones expressed in HEK293 TSA cellshttp:\/\/discovery.ucl.ac.uk\/1322972\/       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/lrrc7-wikipedia\/#breadcrumbitem","name":"LRRC7 &#8211; Wikipedia"}}]}]