[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/man2a1-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/man2a1-wikipedia\/","headline":"MAN2A1 – Wikipedia","name":"MAN2A1 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Alpha-mannosidase 2 is an enzyme that","datePublished":"2022-11-06","dateModified":"2022-11-06","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/man2a1-wikipedia\/","wordCount":5906,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensAlpha-mannosidase 2 is an enzyme that in humans is encoded by the MAN2A1 gene.[5][6][7]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Function[edit]This gene encodes a protein which is a member of family 38 of the glycosyl hydrolases. The protein is located in the Golgi apparatus and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-linked glycosylation) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus.[7]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000112893 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024085 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Moremen KW, Robbins PW (Dec 1991). “Isolation, characterization, and expression of cDNAs encoding murine alpha-mannosidase II, a Golgi enzyme that controls conversion of high mannose to complex N-glycans”. The Journal of Cell Biology. 115 (6): 1521\u201334. doi:10.1083\/jcb.115.6.1521. PMC\u00a02289207. PMID\u00a01757461.^ Oka T, Ungar D, Hughson FM, Krieger M (May 2004). “The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins”. Molecular Biology of the Cell. 15 (5): 2423\u201335. doi:10.1091\/mbc.E03-09-0699. PMC\u00a0404034. PMID\u00a015004235.^ a b “Entrez Gene: MAN2A1 mannosidase, alpha, class 2A, member 1”.Further reading[edit]Land A, Braakman I (Aug 2001). “Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum”. Biochimie. 83 (8): 783\u201390. doi:10.1016\/S0300-9084(01)01314-1. hdl:1874\/5091. PMID\u00a011530211. S2CID\u00a013576808.Dedera DA, Gu RL, Ratner L (Mar 1992). “Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function”. Virology. 187 (1): 377\u201382. doi:10.1016\/0042-6822(92)90331-I. PMID\u00a01736542.Moremen KW, Touster O, Robbins PW (Sep 1991). “Novel purification of the catalytic domain of Golgi alpha-mannosidase II. Characterization and comparison with the intact enzyme”. The Journal of Biological Chemistry. 266 (25): 16876\u201385. doi:10.1016\/S0021-9258(18)55384-9. PMID\u00a01885615.Kalyanaraman VS, Rodriguez V, Veronese F, Rahman R, Lusso P, DeVico AL, Copeland T, Oroszlan S, Gallo RC, Sarngadharan MG (Mar 1990). “Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1”. AIDS Research and Human Retroviruses. 6 (3): 371\u201380. doi:10.1089\/aid.1990.6.371. PMID\u00a02187500.Shimizu H, Tsuchie H, Honma H, Yoshida K, Tsuruoka T, Ushijima H, Kitamura T (Jun 1990). “Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins”. Japanese Journal of Medical Science & Biology. 43 (3): 75\u201387. doi:10.7883\/yoken1952.43.75. PMID\u00a02283726.Leonard CK, Spellman MW, Riddle L, Harris RJ, Thomas JN, Gregory TJ (Jun 1990). “Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells”. The Journal of Biological Chemistry. 265 (18): 10373\u201382. doi:10.1016\/S0021-9258(18)86956-3. PMID\u00a02355006.Pal R, Hoke GM, Sarngadharan MG (May 1989). “Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1”. Proceedings of the National Academy of Sciences of the United States of America. 86 (9): 3384\u20138. Bibcode:1989PNAS…86.3384P. doi:10.1073\/pnas.86.9.3384. PMC\u00a0287137. PMID\u00a02541446.Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP (Jun 1989). “Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport”. Journal of Virology. 63 (6): 2452\u20136. doi:10.1128\/jvi.63.6.2452-2456.1989. PMC\u00a0250699. PMID\u00a02542563.Kozarsky K, Penman M, Basiripour L, Haseltine W, Sodroski J, Krieger M (1989). “Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein”. Journal of Acquired Immune Deficiency Syndromes. 2 (2): 163\u20139. PMID\u00a02649653.Robinson WE, Montefiori DC, Mitchell WM (1988). “Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis”. AIDS Research and Human Retroviruses. 3 (3): 265\u201382. doi:10.1089\/aid.1987.3.265. PMID\u00a02829950.Blough HA, Pauwels R, De Clercq E, Cogniaux J, Sprecher-Goldberger S, Thiry L (Nov 1986). “Glycosylation inhibitors block the expression of LAV\/HTLV-III (HIV) glycoproteins”. Biochemical and Biophysical Research Communications. 141 (1): 33\u20138. doi:10.1016\/S0006-291X(86)80330-8. PMID\u00a03099781.Montefiori DC, Robinson WE, Mitchell WM (Dec 1988). “Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1”. Proceedings of the National Academy of Sciences of the United States of America. 85 (23): 9248\u201352. Bibcode:1988PNAS…85.9248M. doi:10.1073\/pnas.85.23.9248. PMC\u00a0282716. PMID\u00a03264072.Moremen KW, Touster O (Jun 1985). “Biosynthesis and modification of Golgi mannosidase II in HeLa and 3T3 cells”. The Journal of Biological Chemistry. 260 (11): 6654\u201362. doi:10.1016\/S0021-9258(18)88830-5. PMID\u00a03922977.Fenouillet E, Jones I, Powell B, Schmitt D, Kieny MP, Gluckman JC (Jan 1993). “Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain”. Journal of Virology. 67 (1): 150\u201360. doi:10.1128\/jvi.67.1.150-160.1993. PMC\u00a0237347. PMID\u00a08093218.Yeh JC, Seals JR, Murphy CI, van Halbeek H, Cummings RD (Oct 1993). “Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system”. Biochemistry. 32 (41): 11087\u201399. doi:10.1021\/bi00092a019. PMID\u00a08218172.Velasco A, Hendricks L, Moremen KW, Tulsiani DR, Touster O, Farquhar MG (Jul 1993). “Cell type-dependent variations in the subcellular distribution of alpha-mannosidase I and II”. The Journal of Cell Biology. 122 (1): 39\u201351. doi:10.1083\/jcb.122.1.39. PMC\u00a02119607. PMID\u00a08314846.Misago M, Liao YF, Kudo S, Eto S, Mattei MG, Moremen KW, Fukuda MN (Dec 1995). “Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme”. Proceedings of the National Academy of Sciences of the United States of America. 92 (25): 11766\u201370. Bibcode:1995PNAS…9211766M. doi:10.1073\/pnas.92.25.11766. PMC\u00a040483. PMID\u00a08524845.Bolmstedt A, Sj\u00f6lander S, Hansen JE, Akerblom L, Hemming A, Hu SL, Morein B, Olofsson S (Jul 1996). “Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response”. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 12 (3): 213\u201320. doi:10.1097\/00042560-199607000-00001. PMID\u00a08673525.Hu H, Shioda T, Moriya C, Xin X, Hasan MK, Miyake K, Shimada T, Nagai Y (Nov 1996). “Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface”. Journal of Virology. 70 (11): 7462\u201370. doi:10.1128\/jvi.70.11.7462-7470.1996. PMC\u00a0190813. PMID\u00a08892864.       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/man2a1-wikipedia\/#breadcrumbitem","name":"MAN2A1 – Wikipedia"}}]}]