[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/mapkap1-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/mapkap1-wikipedia\/","headline":"MAPKAP1 – Wikipedia","name":"MAPKAP1 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Target of rapamycin complex 2 subunit MAPKAP1 is","datePublished":"2017-07-21","dateModified":"2017-07-21","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/mapkap1-wikipedia\/","wordCount":3934,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensTarget of rapamycin complex 2 subunit MAPKAP1 is a protein that in humans is encoded by the MAPKAP1 gene.[5][6]  As the name indicates, it is a subunit of  mTOR complex 2.This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3′ UTRs have been identified for transcripts of this gene.[6]References[edit]Further reading[edit]Colicelli J, Nicolette C, Birchmeier C,  et\u00a0al. (1991). “Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae”. Proc. Natl. Acad. Sci. U.S.A. 88 (7): 2913\u20137. Bibcode:1991PNAS…88.2913C. doi:10.1073\/pnas.88.7.2913. PMC\u00a051350. PMID\u00a01849280.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Jin J, Smith FD, Stark C,  et\u00a0al. (2004). “Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization”. Curr. Biol. 14 (16): 1436\u201350. doi:10.1016\/j.cub.2004.07.051. PMID\u00a015324660. S2CID\u00a02371325.Gerhard DS, Wagner L, Feingold EA,  et\u00a0al. (2004). “The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121\u20137. doi:10.1101\/gr.2596504. PMC\u00a0528928. PMID\u00a015489334.Schroder W, Bushell G, Sculley T (2005). “The human stress-activated protein kinase-interacting 1 gene encodes JNK-binding proteins”. Cell. Signal. 17 (6): 761\u20137. doi:10.1016\/j.cellsig.2004.10.015. PMID\u00a015722200.Benzinger A, Muster N, Koch HB,  et\u00a0al. (2005). “Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer”. Mol. Cell. Proteomics. 4 (6): 785\u201395. doi:10.1074\/mcp.M500021-MCP200. PMID\u00a015778465.Cheng J, Zhang D, Kim K,  et\u00a0al. (2005). “Mip1, an MEKK2-Interacting Protein, Controls MEKK2 Dimerization and Activation”. Mol. Cell. Biol. 25 (14): 5955\u201364. doi:10.1128\/MCB.25.14.5955-5964.2005. PMC\u00a01168836. PMID\u00a015988011.Venables JP, Bourgeois CF, Dalgliesh C,  et\u00a0al. (2005). “Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon”. Hum. Mol. Genet. 14 (16): 2289\u2013303. doi:10.1093\/hmg\/ddi233. PMID\u00a016000324.Rual JF, Venkatesan K, Hao T,  et\u00a0al. (2005). “Towards a proteome-scale map of the human protein-protein interaction network”. Nature. 437 (7062): 1173\u20138. Bibcode:2005Natur.437.1173R. doi:10.1038\/nature04209. PMID\u00a016189514. S2CID\u00a04427026.Frias MA, Thoreen CC, Jaffe JD,  et\u00a0al. (2006). “mSin1 is necessary for Akt\/PKB phosphorylation, and its isoforms define three distinct mTORC2s”. Curr. Biol. 16 (18): 1865\u201370. doi:10.1016\/j.cub.2006.08.001. PMID\u00a016919458. S2CID\u00a08239162.Jacinto E, Facchinetti V, Liu D,  et\u00a0al. (2006). “SIN1\/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity”. Cell. 127 (1): 125\u201337. doi:10.1016\/j.cell.2006.08.033. PMID\u00a016962653. S2CID\u00a0230319.Yang Q, Inoki K, Ikenoue T, Guan KL (2006). “Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity”. Genes Dev. 20 (20): 2820\u201332. doi:10.1101\/gad.1461206. PMC\u00a01619946. PMID\u00a017043309.Makino C, Sano Y, Shinagawa T,  et\u00a0al. (2007). “Sin1 binds to both ATF-2 and p38 and enhances ATF-2-dependent transcription in an SAPK signaling pathway”. Genes Cells. 11 (11): 1239\u201351. doi:10.1111\/j.1365-2443.2006.01016.x. PMID\u00a017054722. S2CID\u00a010605647.Olsen JV, Blagoev B, Gnad F,  et\u00a0al. (2006). “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks”. Cell. 127 (3): 635\u201348. doi:10.1016\/j.cell.2006.09.026. PMID\u00a017081983. S2CID\u00a07827573.Schroder WA, Buck M, Cloonan N,  et\u00a0al. (2007). “Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling”. Cell. Signal. 19 (6): 1279\u201389. doi:10.1016\/j.cellsig.2007.01.013. PMID\u00a017303383.  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/mapkap1-wikipedia\/#breadcrumbitem","name":"MAPKAP1 – Wikipedia"}}]}]